Published in Proc Natl Acad Sci U S A on May 13, 2009
Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77
A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. Endocrinology (2014) 1.56
The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta (2012) 1.35
Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice. Endocrinology (2010) 1.13
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Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem (2013) 0.98
Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation. Cell Biosci (2011) 0.94
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding. Mol Endocrinol (2012) 0.90
A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol (2011) 0.88
Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity. J Physiol (2010) 0.88
Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res (2011) 0.85
SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β. Mol Cell Endocrinol (2012) 0.82
Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Parasit Vectors (2012) 0.82
Both estrogen receptor α and β stimulate pituitary GH gene expression. Mol Endocrinol (2013) 0.80
Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1). J Biol Chem (2014) 0.79
New insights into thyroid hormone action. Pharmacol Ther (2017) 0.77
Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer. Oncotarget (2016) 0.77
Another story of mice and men: the types of RTH. Proc Natl Acad Sci U S A (2009) 0.75
Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review. Case Rep Endocrinol (2016) 0.75
The actions of thyroid hormone signaling in the nucleus. Mol Cell Endocrinol (2017) 0.75
Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev (1999) 4.92
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Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J (1999) 2.27
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Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta. Proc Natl Acad Sci U S A (1989) 1.85
Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes. J Biol Chem (1989) 1.84
Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone. EMBO J (1999) 1.78
Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA beta gene. Mol Endocrinol (1988) 1.69
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A (2008) 1.62
Variable transcriptional activity and ligand binding of mutant beta 1 3,5,3'-triiodothyronine receptors from four families with generalized resistance to thyroid hormone. Mol Endocrinol (1992) 1.62
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Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box. Proc Natl Acad Sci U S A (1989) 1.54
Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol Cell Biol (1997) 1.52
Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science (1987) 1.50
Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH". J Clin Invest (1975) 1.49
An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A (2001) 1.48
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene. J Clin Invest (1994) 1.46
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. J Clin Invest (1990) 1.42
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Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem (1985) 1.33
Molecular basis of resistance to thyroid hormone. Trends Endocrinol Metab (2003) 1.33
Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest (1999) 1.33
The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation. Mol Cell Biol (1993) 1.31
Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice. Endocrinology (1997) 1.28
Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon. J Biol Chem (1989) 1.26
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers. J Biol Chem (1992) 1.26
Thyroid hormone action: a binding contract. J Clin Invest (2003) 1.24
The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements. Mol Endocrinol (1995) 1.21
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem (2002) 1.21
Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest (2003) 1.16
Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance. J Biol Chem (1993) 1.15
Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci U S A (1987) 1.15
Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons. J Clin Invest (2001) 1.14
Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol (2003) 1.13
The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol (2000) 1.13
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin. J Clin Invest (1999) 1.13
Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem (1998) 1.08
Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol (2005) 1.08
Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest (2005) 1.05
Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol (1998) 1.03
A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab (2006) 1.02
Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. J Biol Chem (1998) 1.00
Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain. J Biol Chem (1996) 0.99
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol (1993) 0.99
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? J Clin Endocrinol Metab (1995) 0.96
Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone. Endocrinology (1998) 0.96
Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor. Mol Cell Endocrinol (2000) 0.93
Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. Endocrinology (1998) 0.92
Understanding the molecular mechanism of dominant negative action of mutant thyroid hormone beta 1-receptors: the important role of the wild-type/mutant receptor heterodimer. Endocrinology (1996) 0.90
Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the hypothalamic paraventricular nucleus. Ciba Found Symp (1992) 0.90
Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations. J Clin Endocrinol Metab (1993) 0.86
A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition. J Biol Chem (1994) 0.83
Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants. Endocrinology (1995) 0.82
Requirement of corepressor binding of thyroid hormone receptor mutants for dominant negative inhibition. Biochem Biophys Res Commun (1998) 0.81
Thyroid hormone decreases thyrotropin subunit mRNA levels in rat anterior pituitary. DNA (1984) 0.81
A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation. Mol Endocrinol (1998) 0.78
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell (2009) 2.69
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med (2004) 1.53
Outcome and toxicity of salvage therapy with 177Lu-octreotate in patients with metastatic gastroenteropancreatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2013) 1.52
Early post-treatment FDG PET predicts survival after 90Y microsphere radioembolization in liver-dominant metastatic colorectal cancer. Eur J Nucl Med Mol Imaging (2014) 1.43
Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol (2006) 1.42
Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology (2009) 1.36
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem (2002) 1.21
Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1). Biol Reprod (2009) 1.21
Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab (2010) 1.20
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes (2008) 1.17
Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest (2003) 1.16
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux. J Biol Chem (2004) 1.08
An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem (2004) 1.06
Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest (2005) 1.05
Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem (2005) 1.00
Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis. J Biol Chem (2012) 0.99
A novel technique for temporally regulated cell type-specific Cre expression and recombination in the pituitary gonadotroph. J Mol Endocrinol (2006) 0.99
Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis. J Biol Chem (2005) 0.97
Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. Mol Endocrinol (2011) 0.97
Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK). J Biol Chem (2014) 0.93
Thyroid hormone action is required for normal cone opsin expression during mouse retinal development. Invest Ophthalmol Vis Sci (2008) 0.92
In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice. Endocrinology (2009) 0.90
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding. Mol Endocrinol (2012) 0.90
Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage. Mol Endocrinol (2013) 0.89
Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone. Mol Endocrinol (2003) 0.87
Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development. Mol Cell Neurosci (2010) 0.87
The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology (2012) 0.86
Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice. Cell Physiol Biochem (2011) 0.84
Thyroid hormones stimulate renal expression of CFTR. Cell Physiol Biochem (2007) 0.83
Daily exposure to silver nanoparticles during prepubertal development decreases adult sperm and reproductive parameters. Nanotoxicology (2014) 0.82
Thyroid hormone and estradiol have overlapping effects on kidney glutathione S-transferase-α gene expression. Am J Physiol Endocrinol Metab (2012) 0.81
Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP). Mol Cell Endocrinol (2005) 0.80
Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology (2003) 0.80
Prevalence and associated features of restless legs syndrome in a population of Iranian women during pregnancy. Int J Gynaecol Obstet (2013) 0.79
The autocrine/paracrine regulation of thyrotropin secretion. Thyroid (2003) 0.79
The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab (2005) 0.79
Cinnamon extract improves the body composition and attenuates lipogenic processes in the liver and adipose tissue of rats. Food Funct (2015) 0.78
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice. Mol Cell Biol (2012) 0.78
Specific efficacy of peptide receptor radionuclide therapy with (177)Lu-octreotate in advanced neuroendocrine tumours of the small intestine. Eur J Nucl Med Mol Imaging (2015) 0.77
Bone metastases in GEP-NET: response and long-term outcome after PRRT from a follow-up analysis. Am J Nucl Med Mol Imaging (2013) 0.77
Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor. Endocrinology (2008) 0.77
Pemberton's sign: explained nearly 70 years later. J Clin Endocrinol Metab (2014) 0.76
Restless legs syndrome in Iranian patients with multiple sclerosis. Neurol Sci (2012) 0.76
TRH testing in its infancy. J Clin Endocrinol Metab (2008) 0.75
Welcome to the 84th annual meeting of the American Thyroid Association. Thyroid (2014) 0.75
Impact of Thyroid Hormones on Estrogen Receptor α-Dependent Transcriptional Mechanisms in Ventromedial Hypothalamus and Preoptic Area. Neuroendocrinology (2015) 0.75