Published in Mol Cell Biol on August 14, 2006
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell (2010) 4.16
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
Retracted Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery. Am J Physiol Endocrinol Metab (2012) 1.74
SerpinB1 Promotes Pancreatic β Cell Proliferation. Cell Metab (2015) 1.72
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A (2008) 1.56
Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metab (2015) 1.56
The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene (2009) 1.45
The role of oestrogens in the adaptation of islets to insulin resistance. J Physiol (2009) 1.37
Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab (2011) 1.27
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell (2011) 1.26
Research resource: the pdx1 cistrome of pancreatic islets. Mol Endocrinol (2012) 1.17
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes (2008) 1.17
Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology (2010) 1.17
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes (2012) 1.08
Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A. Diabetes (2013) 0.96
Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol (2014) 0.96
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast. Mol Cell Biol (2015) 0.92
CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Mol Metab (2014) 0.91
Accumulation of cadmium in insulin-producing β cells. Islets (2012) 0.85
Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metab (2016) 0.85
R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue. J Biol Chem (2010) 0.83
Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. Proc Natl Acad Sci U S A (2015) 0.83
Repurposing cAMP-modulating medications to promote β-cell replication. Mol Endocrinol (2014) 0.82
Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice. Proc Natl Acad Sci U S A (2015) 0.82
Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm (2013) 0.81
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control. Diabetes (2014) 0.78
Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes. Hum Mol Genet (2014) 0.78
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
An assay for small scale screening of candidate β cell proliferative factors using intact islets. Biotechniques (2013) 0.78
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice. Mol Cell Biol (2012) 0.78
Protein phosphatases in pancreatic islets. J Endocrinol (2014) 0.77
SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes (2016) 0.77
The expression and function of histamine H₃ receptors in pancreatic beta cells. Br J Pharmacol (2014) 0.77
Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology (2016) 0.75
Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner. JCI Insight (2017) 0.75
Phosphorylation of carboxypeptidase B1 protein regulates β-cell proliferation. Int J Mol Med (2017) 0.75
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell (1989) 11.41
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature (1994) 9.37
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res (1988) 8.53
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell (1999) 6.53
Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest (2004) 4.12
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
Transcriptional regulation by cyclic AMP. Annu Rev Biochem (1997) 3.81
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J (1999) 3.70
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
The glucagon-like peptides. Endocr Rev (1999) 3.51
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem (2002) 3.08
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes (2001) 2.95
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med (1996) 2.94
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology (2004) 2.65
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest (2003) 2.63
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature (1993) 2.52
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes (2000) 2.50
Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A (2001) 2.44
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.29
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes (2004) 2.17
beta-cell turnover: its assessment and implications. Diabetes (2001) 1.90
Islet growth and development in the adult. J Mol Endocrinol (2000) 1.86
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest (2003) 1.83
Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology (2001) 1.78
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology (2004) 1.69
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology (2003) 1.60
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med (2004) 1.53
beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes (2002) 1.33
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol (2004) 1.28
Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology (1997) 1.28
Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology (2002) 1.17
Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells. J Biol Chem (2002) 1.04
A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol (1999) 1.02
Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells. Am J Physiol Endocrinol Metab (2004) 0.97
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells. Diabetes (2000) 0.95
A comparison of proliferation markers (BrdUrd, Ki-67, PCNA) determined at each cell position in the crypts of normal human colonic mucosa. Eur J Histochem (1996) 0.91
Induction of beta-cell neogenesis by islet injury. Diabetes Metab Rev (1996) 0.86
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell (2009) 2.69
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med (2004) 1.53
Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology (2009) 1.36
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell (2011) 1.26
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem (2002) 1.21
Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1). Biol Reprod (2009) 1.21
Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab (2010) 1.20
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes (2008) 1.17
Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest (2003) 1.16
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo. Proc Natl Acad Sci U S A (2009) 1.08
An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem (2004) 1.06
Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest (2005) 1.05
Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem (2005) 1.00
Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis. J Biol Chem (2012) 0.99
A novel technique for temporally regulated cell type-specific Cre expression and recombination in the pituitary gonadotroph. J Mol Endocrinol (2006) 0.99
Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis. J Biol Chem (2005) 0.97
Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. Mol Endocrinol (2011) 0.97
Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK). J Biol Chem (2014) 0.93
Thyroid hormone action is required for normal cone opsin expression during mouse retinal development. Invest Ophthalmol Vis Sci (2008) 0.92
In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice. Endocrinology (2009) 0.90
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding. Mol Endocrinol (2012) 0.90
Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage. Mol Endocrinol (2013) 0.89
Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone. Mol Endocrinol (2003) 0.87
Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development. Mol Cell Neurosci (2010) 0.87
The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology (2012) 0.86
Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice. Cell Physiol Biochem (2011) 0.84
Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP). Mol Cell Endocrinol (2005) 0.80
Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology (2003) 0.80
The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab (2005) 0.79
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice. Mol Cell Biol (2012) 0.78
Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor. Endocrinology (2008) 0.77
Increasing β-cell mass requires additional stimulation for adaptation to secretory demand. Mol Endocrinol (2015) 0.76
TRH testing in its infancy. J Clin Endocrinol Metab (2008) 0.75
Welcome to the 84th annual meeting of the American Thyroid Association. Thyroid (2014) 0.75