Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion.

PubWeight™: 3.13‹?› | Rank: Top 1%

🔗 View Article (PMC 3140054)

Published in Neuron on May 14, 2009

Authors

Andrew D Huberman1, Wei Wei, Justin Elstrott, Ben K Stafford, Marla B Feller, Ben A Barres

Author Affiliations

1: Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA. adh1@stanford.edu

Articles citing this

(truncated to the top 100)

The neuronal organization of the retina. Neuron (2012) 3.13

Design principles of insect and vertebrate visual systems. Neuron (2010) 2.94

Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron (2010) 2.91

Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc Natl Acad Sci U S A (2012) 2.45

Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers. J Neurosci (2010) 2.44

Parametric functional maps of visual inputs to the tectum. Neuron (2012) 2.22

Development of asymmetric inhibition underlying direction selectivity in the retina. Nature (2010) 2.09

Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. J Neurosci (2011) 2.04

Diverse visual features encoded in mouse lateral geniculate nucleus. J Neurosci (2013) 1.95

Direction selectivity in the retina: symmetry and asymmetry in structure and function. Nat Rev Neurosci (2012) 1.86

Parallel processing of visual space by neighboring neurons in mouse visual cortex. Nat Neurosci (2010) 1.84

Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing. J Neurosci (2011) 1.77

Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit. Neuron (2011) 1.67

What can mice tell us about how vision works? Trends Neurosci (2011) 1.65

The most numerous ganglion cell type of the mouse retina is a selective feature detector. Proc Natl Acad Sci U S A (2012) 1.59

Contactin-4 mediates axon-target specificity and functional development of the accessory optic system. Neuron (2015) 1.57

Anterior-posterior direction opponency in the superficial mouse lateral geniculate nucleus. Neuron (2012) 1.53

Visual receptive field properties of neurons in the superficial superior colliculus of the mouse. J Neurosci (2010) 1.53

Functional assembly of accessory optic system circuitry critical for compensatory eye movements. Neuron (2015) 1.52

Molecular mechanisms of synaptic specificity in developing neural circuits. Neuron (2010) 1.46

Parallel input channels to mouse primary visual cortex. J Neurosci (2010) 1.43

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature (2012) 1.40

Retinal origin of direction selectivity in the superior colliculus. Nat Neurosci (2017) 1.39

A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex. Nature (2014) 1.37

Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina. Nat Protoc (2010) 1.35

Retinal ganglion cell maps in the brain: implications for visual processing. Curr Opin Neurobiol (2013) 1.32

Development of single retinofugal axon arbors in normal and β2 knock-out mice. J Neurosci (2011) 1.30

Orientation-selective responses in the mouse lateral geniculate nucleus. J Neurosci (2013) 1.30

Parallel mechanisms encode direction in the retina. Neuron (2011) 1.26

Molecular and cellular mechanisms of lamina-specific axon targeting. Cold Spring Harb Perspect Biol (2010) 1.26

Assembly of lamina-specific neuronal connections by slit bound to type IV collagen. Cell (2011) 1.22

Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization. J Neurosci (2013) 1.22

Switching retinogeniculate axon laterality leads to normal targeting but abnormal eye-specific segregation that is activity dependent. J Neurosci (2009) 1.21

Physiological clustering of visual channels in the mouse retina. J Neurophysiol (2011) 1.21

Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types. Curr Biol (2014) 1.21

Organization and development of direction-selective circuits in the retina. Trends Neurosci (2011) 1.21

Characterization of genetically targeted neuron types in the zebrafish optic tectum. Front Neural Circuits (2011) 1.16

Wiring and rewiring of the retinogeniculate synapse. Curr Opin Neurobiol (2011) 1.15

Stereotyped axonal arbors of retinal ganglion cell subsets in the mouse superior colliculus. J Comp Neurol (2011) 1.13

On and off retinal circuit assembly by divergent molecular mechanisms. Science (2013) 1.12

Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience (2009) 1.11

Age-related alterations in neurons of the mouse retina. J Neurosci (2011) 1.10

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling. Vision Res (2010) 1.10

A genetic and computational approach to structurally classify neuronal types. Nat Commun (2014) 1.08

Assembly and disassembly of a retinal cholinergic network. Vis Neurosci (2011) 1.08

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement. Neuron (2016) 1.08

Tbr2 is required to generate a neural circuit mediating the pupillary light reflex. J Neurosci (2014) 1.05

Non-centered spike-triggered covariance analysis reveals neurotrophin-3 as a developmental regulator of receptive field properties of ON-OFF retinal ganglion cells. PLoS Comput Biol (2010) 1.04

Spontaneous activity promotes synapse formation in a cell-type-dependent manner in the developing retina. J Neurosci (2012) 1.03

Precise lamination of retinal axons generates multiple parallel input pathways in the tectum. J Neurosci (2013) 1.03

Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection. J Neurosci Methods (2012) 1.03

Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci (2013) 1.02

Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition. Front Neural Circuits (2012) 1.02

Neuronal cell types and connectivity: lessons from the retina. Neuron (2014) 1.01

A systems-based dissection of retinal inputs to the zebrafish tectum reveals different rules for different functional classes during development. J Neurosci (2013) 0.98

Stream-related preferences of inputs to the superior colliculus from areas of dorsal and ventral streams of mouse visual cortex. J Neurosci (2013) 0.97

Functional architecture of the retina: development and disease. Prog Retin Eye Res (2014) 0.96

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. Neural Dev (2014) 0.95

Visual stimulation reverses the directional preference of direction-selective retinal ganglion cells. Neuron (2012) 0.95

Birthdate and outgrowth timing predict cellular mechanisms of axon target matching in the developing visual pathway. Cell Rep (2014) 0.95

Direction-selective ganglion cells show symmetric participation in retinal waves during development. J Neurosci (2010) 0.92

Orientation columns in the mouse superior colliculus. Nature (2014) 0.92

Reelin is required for class-specific retinogeniculate targeting. J Neurosci (2011) 0.91

An isolated retinal preparation to record light response from genetically labeled retinal ganglion cells. J Vis Exp (2011) 0.90

Emergence of lamina-specific retinal ganglion cell connectivity by axon arbor retraction and synapse elimination. J Neurosci (2010) 0.90

Fine spatial information represented in a population of retinal ganglion cells. J Neurosci (2011) 0.90

Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex. J Neurosci (2012) 0.90

Subtype-dependent postnatal development of direction- and orientation-selective retinal ganglion cells in mice. J Neurophysiol (2014) 0.88

Morphology of superior colliculus- and middle temporal area-projecting neurons in primate primary visual cortex. J Comp Neurol (2012) 0.88

Organotypic tissue culture of adult rodent retina followed by particle-mediated acute gene transfer in vitro. PLoS One (2010) 0.88

Direction-selective circuitry in rat retina develops independently of GABAergic, cholinergic and action potential activity. PLoS One (2011) 0.87

Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction. J Neurosci (2015) 0.87

Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line. J Comp Neurol (2013) 0.87

Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina. J Neurosci (2015) 0.87

Direction selectivity in the visual system of the zebrafish larva. Front Neural Circuits (2013) 0.86

Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification. PLoS One (2013) 0.86

Retinal and Tectal "Driver-Like" Inputs Converge in the Shell of the Mouse Dorsal Lateral Geniculate Nucleus. J Neurosci (2015) 0.86

Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex. J Neurophysiol (2014) 0.85

The laminar development of direction selectivity in ferret visual cortex. J Neurosci (2012) 0.85

Developmental changes in NMDA receptor subunit composition at ON and OFF bipolar cell synapses onto direction-selective retinal ganglion cells. J Neurosci (2014) 0.85

Directional selective neurons in the awake LGN: response properties and modulation by brain state. J Neurophysiol (2014) 0.84

Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep (2016) 0.84

Highly Efficient Delivery of Adeno-Associated Viral Vectors to the Primate Retina. Hum Gene Ther (2016) 0.83

Rearrangement of retinogeniculate projection patterns after eye-specific segregation in mice. PLoS One (2010) 0.83

Shared and distinct retinal input to the mouse superior colliculus and dorsal lateral geniculate nucleus. J Neurophysiol (2016) 0.82

Different roles of axon guidance cues and patterned spontaneous activity in establishing receptive fields in the mouse superior colliculus. Front Neural Circuits (2014) 0.82

Activity-dependent disruption of intersublaminar spaces and ABAKAN expression does not impact functional on and off organization in the ferret retinogeniculate system. Neural Dev (2011) 0.82

Candidate molecular mechanisms for establishing cell identity in the developing retina. Dev Neurobiol (2011) 0.82

Visual Receptive Field Properties of Neurons in the Mouse Lateral Geniculate Nucleus. PLoS One (2016) 0.81

FoxP2 is a parvocellular-specific transcription factor in the visual thalamus of monkeys and ferrets. Cereb Cortex (2012) 0.81

An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. J Neurosci (2015) 0.81

Shedding light on class-specific wiring: development of intrinsically photosensitive retinal ganglion cell circuitry. Mol Neurobiol (2011) 0.81

Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus. Neural Dev (2014) 0.81

Visual coding with a population of direction-selective neurons. J Neurophysiol (2015) 0.81

Developmental mechanisms that regulate retinal ganglion cell dendritic morphology. Dev Neurobiol (2011) 0.80

So many pieces, one puzzle: cell type specification and visual circuitry in flies and mice. Genes Dev (2014) 0.80

Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol (2012) 0.80

From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response. Cell (2016) 0.79

The distribution of the preferred directions of the ON-OFF direction selective ganglion cells in the rabbit retina requires refinement after eye opening. Physiol Rep (2013) 0.79

Synaptic Pattern of KA1 and KA2 upon the Direction-Selective Ganglion Cells in Developing and Adult Mouse Retina. Acta Histochem Cytochem (2012) 0.79

Articles cited by this

The Psychophysics Toolbox. Spat Vis (1997) 62.63

The VideoToolbox software for visual psychophysics: transforming numbers into movies. Spat Vis (1997) 42.97

Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J Physiol (1962) 33.15

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature (2003) 16.48

The major cell populations of the mouse retina. J Neurosci (1998) 7.18

Parallel processing in the mammalian retina. Nat Rev Neurosci (2004) 5.86

Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells. Neuron (2008) 3.41

Molecular identification of a retinal cell type that responds to upward motion. Nature (2008) 3.28

Large-scale morphological survey of mouse retinal ganglion cells. J Comp Neurol (2002) 3.19

Vertical interactions across ten parallel, stacked representations in the mammalian retina. Nature (2001) 3.08

Selective sensitivity to direction of movement in ganglion cells of the rabbit retina. Science (1963) 2.95

Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts. Neuron (2004) 2.78

The density recovery profile: a method for the analysis of points in the plane applicable to retinal studies. Vis Neurosci (1991) 2.43

Targeted whole-cell recordings in the mammalian brain in vivo. Neuron (2003) 2.35

The analysis of image motion by the rabbit retina. J Physiol (1968) 2.02

Quantitative characterization of visual response properties in the mouse dorsal lateral geniculate nucleus. J Neurophysiol (2003) 1.96

Identification of ON-OFF direction-selective ganglion cells in the mouse retina. J Physiol (2004) 1.91

Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves. Neuron (2008) 1.85

Cellular mechanisms for direction selectivity in the retina. Neuron (2007) 1.83

Spatial properties of retinal mosaics: an empirical evaluation of some existing measures. Vis Neurosci (1996) 1.80

Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion. PLoS One (2009) 1.77

The accessory optic system. Annu Rev Neurosci (1984) 1.73

Receptive fields and dendritic structure of directionally selective retinal ganglion cells. J Neurosci (1994) 1.37

ON direction-selective ganglion cells in the mouse retina. J Physiol (2006) 1.33

Effect of visual experience on the maturation of ON-OFF direction selective ganglion cells in the rabbit retina. Vision Res (2008) 1.27

Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina. J Physiol (2008) 1.24

Almost all ganglion cells in the rabbit retina project to the superior colliculus. Brain Res (1981) 1.11

Receptive-field characteristics of lateral geniculate neurons in the rabbit. J Neurophysiol (1971) 1.03

Dendritic morphologies of retinal ganglion cells projecting to the nucleus of the optic tract in the rabbit. J Comp Neurol (1990) 1.01

Image processing: how the retina detects the direction of image motion. Curr Biol (2007) 0.98

Articles by these authors

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27

The calpain system. Physiol Rev (2003) 9.95

The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell (2005) 7.41

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84

Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature (2010) 5.47

Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2008) 4.63

Metastatic patterns in adenocarcinoma. Cancer (2006) 4.16

Mechanisms underlying development of visual maps and receptive fields. Annu Rev Neurosci (2008) 4.00

Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci (2006) 3.84

Genomic analysis of reactive astrogliosis. J Neurosci (2012) 3.62

Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science (2002) 3.54

Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development. Neuron (2003) 3.52

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46

Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells. Neuron (2008) 3.41

Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37

Mechanisms underlying spontaneous patterned activity in developing neural circuits. Nat Rev Neurosci (2009) 3.30

NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron (2004) 3.24

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A (2009) 3.17

Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11

Regulation of synaptic connectivity by glia. Nature (2010) 3.02

Microglia: scapegoat, saboteur, or something else? Science (2013) 2.94

Neuroscience: Glia - more than just brain glue. Nature (2009) 2.76

Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron (2008) 2.74

DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Neuron (2009) 2.73

Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci (2007) 2.70

NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68

Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol (2010) 2.68

Functional genomic analysis of oligodendrocyte differentiation. J Neurosci (2006) 2.64

Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol (2013) 2.64

Signaling between glia and neurons: focus on synaptic plasticity. Curr Opin Neurobiol (2005) 2.62

Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma. Nat Genet (2003) 2.55

The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci (2012) 2.53

Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia. Nat Genet (2011) 2.48

Emerging roles of astrocytes in neural circuit development. Nat Rev Neurosci (2013) 2.45

Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron (2002) 2.41

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30

Astrocytes and disease: a neurodevelopmental perspective. Genes Dev (2012) 2.28

Axon degeneration: molecular mechanisms of a self-destruction pathway. J Cell Biol (2012) 2.26

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest (2011) 2.25

Spontaneous patterned retinal activity and the refinement of retinal projections. Prog Neurobiol (2005) 2.20

Design and Integration of a Telerobotic System for Minimally Invasive Surgery of the Throat. Int J Rob Res (2009) 2.18

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18

Role for glia in synaptogenesis. Glia (2004) 2.15

Development of asymmetric inhibition underlying direction selectivity in the retina. Nature (2010) 2.09

The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One (2010) 2.06

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron (2005) 2.06

Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients. Hepatology (2003) 2.05

Development of a method for the purification and culture of rodent astrocytes. Neuron (2011) 1.92

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature (2012) 1.92

Between the sheets: a molecular sieve makes myelin membranes. Dev Cell (2011) 1.87

Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers. J Neurosci (2002) 1.87

Importance of intrinsic mechanisms in cell fate decisions in the developing rat retina. Neuron (2003) 1.86

Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves. Neuron (2008) 1.85

Mussel protein adhesion depends on interprotein thiol-mediated redox modulation. Nat Chem Biol (2011) 1.82

High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections. Nat Neurosci (2004) 1.81

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol (2007) 1.79

Surface charge affects cellular uptake and intracellular trafficking of chitosan-based nanoparticles. Biomacromolecules (2011) 1.79

Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing. J Neurosci (2011) 1.77

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells. Proc Natl Acad Sci U S A (2011) 1.76

Neuronal pentraxins mediate synaptic refinement in the developing visual system. J Neurosci (2006) 1.71

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife (2012) 1.69

Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. J Neurosci (2006) 1.67

Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit. Neuron (2011) 1.67

Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol (2014) 1.67

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proc Natl Acad Sci U S A (2011) 1.65

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab (2008) 1.59

A role for correlated spontaneous activity in the assembly of neural circuits. Neuron (2013) 1.57

Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis. J Hepatol (2008) 1.55

Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL. Pediatr Blood Cancer (2013) 1.54

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase. Nat Commun (2013) 1.50

Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology (2012) 1.50

Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation. Gastroenterology (2011) 1.50

The changes of pulmonary blood flow in non-ventilated lung during one lung ventilation. J Clin Monit Comput (2010) 1.49

Many patients 80 years and older with advanced non-small cell lung cancer (NSCLC) can tolerate chemotherapy. J Thorac Oncol (2007) 1.48

Soybean NAC transcription factors promote abiotic stress tolerance and lateral root formation in transgenic plants. Plant J (2011) 1.48

The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci (2005) 1.46

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol (2013) 1.45

Morphologic classification of microvessels in hepatocellular carcinoma is associated with the prognosis after resection. J Gastroenterol Hepatol (2011) 1.45

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med (2008) 1.45

A novel mutation within the 2B rod domain of keratin 9 in a Chinese pedigree with epidermolytic palmoplantar keratoderma combined with knuckle pads and camptodactyly. Eur J Dermatol (2011) 1.44

Uropygial gland-secreted alkanols contribute to olfactory sex signals in budgerigars. Chem Senses (2010) 1.44

A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci (2008) 1.44

Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma. Cancer (2010) 1.44

Unbiased analysis of bulk axonal segregation patterns. J Neurosci Methods (2004) 1.43

Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosis. Anticancer Drugs (2013) 1.42

Continuous low-dose cyclophosphamide and prednisone in the treatment of relapsed/refractory multiple myeloma with severe heart failure. Leuk Lymphoma (2014) 1.42

Application of biologically based computer modeling to simple or complex mixtures. Environ Health Perspect (2002) 1.42

Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol (2006) 1.41

Effects of interfacial redox in mussel adhesive protein films on mica. Adv Mater (2011) 1.41

Intraoperative sonography during open partial nephrectomy for renal cell cancer: does it alter surgical management? AJR Am J Roentgenol (2014) 1.41

Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. Clin Cancer Res (2009) 1.40

Long-term outcomes of 1,263 patients with mycosis fungoides and Sézary syndrome from 1982 to 2009. Clin Cancer Res (2012) 1.39

Wheat WRKY genes TaWRKY2 and TaWRKY19 regulate abiotic stress tolerance in transgenic Arabidopsis plants. Plant Cell Environ (2012) 1.38