Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination.

PubWeight™: 3.37‹?› | Rank: Top 1%

🔗 View Article (PMC 2843397)

Published in Neuron on March 11, 2010

Authors

Jason C Dugas1, Trinna L Cuellar, Anja Scholze, Brandon Ason, Adiljan Ibrahim, Ben Emery, Jennifer L Zamanian, Lynette C Foo, Michael T McManus, Ben A Barres

Author Affiliations

1: Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA. jcdugas@alum.mit.edu

Articles citing this

(truncated to the top 100)

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci (2012) 2.52

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. FASEB J (2010) 1.87

Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter. Acta Neuropathol (2010) 1.71

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66

Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci (2011) 1.52

Specific functions for ERK/MAPK signaling during PNS development. Neuron (2011) 1.45

MicroRNAs: regulators of neuronal fate. Curr Opin Cell Biol (2013) 1.43

Regulation of microRNA function in somatic stem cell proliferation and differentiation. Nat Rev Mol Cell Biol (2014) 1.38

Glutamatergic model psychoses: prediction error, learning, and inference. Neuropsychopharmacology (2010) 1.34

MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS One (2010) 1.24

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol (2013) 1.24

The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders. Front Psychiatry (2012) 1.22

MicroRNA-deficient Schwann cells display congenital hypomyelination. J Neurosci (2010) 1.19

The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol (2013) 1.18

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nat Neurosci (2013) 1.16

Identification of a gene regulatory network necessary for the initiation of oligodendrocyte differentiation. PLoS One (2011) 1.11

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol (2013) 1.11

MicroRNA in central nervous system trauma and degenerative disorders. Physiol Genomics (2011) 1.10

MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord. J Neurosci (2010) 1.10

Oligodendrocyte fate after spinal cord injury. Neurotherapeutics (2011) 1.09

The emerging role of microRNAs in multiple sclerosis. Nat Rev Neurol (2010) 1.08

Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One (2010) 1.07

Oligodendrogenesis after cerebral ischemia. Front Cell Neurosci (2013) 1.06

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia (2013) 1.05

Extracellular vesicles round off communication in the nervous system. Nat Rev Neurosci (2016) 1.04

Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proc Natl Acad Sci U S A (2011) 1.01

Pathophysiology of glia in perinatal white matter injury. Glia (2014) 1.00

Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. J Neurosci (2015) 0.99

Functions of GSK-3 Signaling in Development of the Nervous System. Front Mol Neurosci (2011) 0.99

Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury. PLoS One (2012) 0.98

MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One (2012) 0.98

Developmental regulation of microRNA expression in Schwann cells. Mol Cell Biol (2011) 0.98

miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma. PLoS One (2013) 0.97

MicroRNAs in neural cell differentiation. Brain Res (2010) 0.97

A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res (2014) 0.97

Transcriptome analysis of microRNAs in developing cerebral cortex of rat. BMC Genomics (2012) 0.96

Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro. Exp Neurol (2011) 0.96

Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96

Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer (2014) 0.96

Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development (2013) 0.95

The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration. Mol Cell Neurosci (2012) 0.95

Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J (2015) 0.95

MicroRNAs and Multiple Sclerosis. Autoimmune Dis (2010) 0.94

Unwrapping myelination by microRNAs. Neuroscientist (2011) 0.94

Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes. Front Genet (2012) 0.94

Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci (2013) 0.94

Sox6, jack of all trades: a versatile regulatory protein in vertebrate development. Dev Dyn (2011) 0.94

Oligodendrocytes and the "micro brake" of progenitor cell proliferation. Neuron (2010) 0.94

The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells. Mol Cell Biol (2013) 0.93

A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation. Glia (2014) 0.93

Isolation of cortical mouse oligodendrocyte precursor cells. J Neurosci Methods (2012) 0.93

Mediators of oligodendrocyte differentiation during remyelination. FEBS Lett (2011) 0.93

MicroRNA dysregulation in multiple sclerosis. Front Genet (2013) 0.92

Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells. J Biol Chem (2012) 0.91

MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics. Front Cell Neurosci (2014) 0.91

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes Dev (2013) 0.91

MicroRNAs and glial cell development. Neuroscientist (2011) 0.90

miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins. Dev Cell (2013) 0.90

MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A (2013) 0.90

MicroRNAs in oligodendrocyte and Schwann cell differentiation. Dev Neurosci (2011) 0.90

Glial cell development and function in zebrafish. Cold Spring Harb Perspect Biol (2014) 0.90

Polydendrocytes in development and myelin repair. Neurosci Bull (2013) 0.90

Fine-Tuning Oligodendrocyte Development by microRNAs. Front Neurosci (2012) 0.89

miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Neuroscience (2012) 0.89

Coordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues. Neurosci Bull (2013) 0.88

The myelin brake: when enough is enough. Sci Signal (2010) 0.88

miR-200 and miR-96 families repress neural induction from human embryonic stem cells. Development (2013) 0.88

Towards resolving the transcription factor network controlling myelin gene expression. Nucleic Acids Res (2011) 0.88

Oligodendrogenesis in the normal and pathological central nervous system. Front Neurosci (2014) 0.87

Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation. Front Neurosci (2012) 0.86

High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain. Brain Res (2010) 0.86

Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells. PLoS One (2010) 0.86

Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance. J Biol Chem (2015) 0.85

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun (2015) 0.85

Myelin basic protein synthesis is regulated by small non-coding RNA 715. EMBO Rep (2012) 0.85

The RE1 binding protein REST regulates oligodendrocyte differentiation. J Neurosci (2011) 0.84

Tuning the cell fate of neurons and glia by microRNAs. Curr Opin Neurobiol (2013) 0.84

New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development. BMC Neurosci (2014) 0.84

Diversity Matters: A Revised Guide to Myelination. Trends Cell Biol (2015) 0.83

Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis. Nucleic Acids Res (2012) 0.83

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet (2015) 0.82

Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration. Brain Res (2015) 0.82

Promoting brain remodeling to aid in stroke recovery. Trends Mol Med (2015) 0.82

Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non-coding RNAs. Transl Neurodegener (2014) 0.82

Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a. Mol Biol Cell (2012) 0.82

Specification of neural cell fate and regulation of neural stem cell proliferation by microRNAs. Am J Stem Cells (2012) 0.82

Tcf7l2 is tightly controlled during myelin formation. Cell Mol Neurobiol (2011) 0.82

miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells. Neural Regen Res (2014) 0.82

How to make an oligodendrocyte. Development (2015) 0.81

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination. J Neurosci (2016) 0.81

Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. Neurochem Res (2011) 0.81

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. Nat Commun (2016) 0.80

Adult-onset autosomal dominant leukodystrophy: linking nuclear envelope to myelin. J Neurosci (2011) 0.80

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage. Glia (2015) 0.80

MicroRNA and transcriptional crosstalk in myelinating glia. Neurochem Int (2014) 0.80

Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells. Skelet Muscle (2013) 0.80

Ontogeny of small RNA in the regulation of mammalian brain development. BMC Genomics (2014) 0.79

What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev Neurother (2014) 0.79

Heterogeneity of oligodendrocyte progenitor cells in adult human brain. Ann Clin Transl Neurol (2014) 0.79

MicroRNA expression in mouse oligodendrocytes and regulation of proteolipid protein gene expression. J Neurosci Res (2012) 0.79

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27

Dicer is essential for mouse development. Nat Genet (2003) 15.87

MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature (1983) 6.52

limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics (2004) 6.04

Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev (2001) 5.50

Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue. Clin Cancer Res (2008) 5.46

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet (2003) 5.43

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell (2002) 5.35

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

microRNA modulation of circadian-clock period and entrainment. Neuron (2007) 4.49

Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron (2000) 3.91

Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs. Mol Cell (2008) 3.41

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res (2008) 3.20

Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J Neurosci (2008) 2.95

Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215. Cancer Res (2008) 2.86

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development (1994) 2.83

MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80

Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron (2008) 2.74

NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68

Functional genomic analysis of oligodendrocyte differentiation. J Neurosci (2006) 2.64

MicroRNAs and cell cycle regulation. Cell Cycle (2007) 2.62

Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J (2008) 2.58

Multiple extracellular signals are required for long-term oligodendrocyte survival. Development (1993) 2.55

Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J Neurosci (2006) 2.43

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32

Clonal analysis of oligodendrocyte development in culture: evidence for a developmental clock that counts cell divisions. Cell (1986) 2.31

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18

MicroRNA profiling in human medulloblastoma. Int J Cancer (2009) 2.12

Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron (1998) 2.11

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A (2009) 2.00

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev (2000) 2.00

Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies. J Neurosci Res (2002) 1.93

PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol (2006) 1.93

A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Neuron (2001) 1.92

Crosstalk between cell cycle regulators and the myogenic factor MyoD in skeletal myoblasts. Cell Mol Life Sci (2001) 1.89

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell (2006) 1.79

Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol (2007) 1.70

Control of oligodendrocyte number in the developing rat optic nerve. Neuron (1994) 1.68

A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays (2000) 1.63

RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression. J Biol Chem (1998) 1.50

Differentiation of a bipotential glial progenitor cell in a single cell microculture. Nature (1985) 1.37

PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain. Glia (2009) 1.24

Control of keratinocyte proliferation and differentiation by p63. Cell Cycle (2007) 1.24

Cell number control and timing in animal development: the oligodendrocyte cell lineage. Int J Dev Biol (1998) 1.14

The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol (2009) 1.13

Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein. EMBO J (2001) 1.01

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells. Int J Cancer (2000) 0.98

Relationship between cell cycle molecules and onset of oligodendrocyte differentiation. J Neurosci Res (2003) 0.97

Coordination of cell cycle exit and differentiation of neuronal progenitors. Cell Cycle (2008) 0.95

FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome. Dev Dyn (2004) 0.92

Platelet-derived growth factor is a mitogen for glial but not for neuronal rat brain cells in vitro. Neurosci Lett (1987) 0.84

Evidence for the association of 2',3'-cyclic-nucleotide 3'-phosphodiesterase with myelin-related membranes in peripheral nervous system. J Neurochem (1980) 0.82

Articles by these authors

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16

The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell (2005) 7.41

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56

Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature (2010) 5.47

Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68

Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78

Genomic analysis of reactive astrogliosis. J Neurosci (2012) 3.62

Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science (2002) 3.54

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46

Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells. Neuron (2008) 3.41

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron (2004) 3.24

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A (2009) 3.17

Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion. Neuron (2009) 3.13

Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11

Regulation of synaptic connectivity by glia. Nature (2010) 3.02

Microglia: scapegoat, saboteur, or something else? Science (2013) 2.94

MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80

Neuroscience: Glia - more than just brain glue. Nature (2009) 2.76

Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76

Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron (2008) 2.74

Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci (2007) 2.70

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69

NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68

Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol (2010) 2.68

Functional genomic analysis of oligodendrocyte differentiation. J Neurosci (2006) 2.64

Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol (2013) 2.64

Signaling between glia and neurons: focus on synaptic plasticity. Curr Opin Neurobiol (2005) 2.62

The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci (2012) 2.53

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet (2013) 2.46

Emerging roles of astrocytes in neural circuit development. Nat Rev Neurosci (2013) 2.45

Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron (2002) 2.41

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32

Astrocytes and disease: a neurodevelopmental perspective. Genes Dev (2012) 2.28

Axon degeneration: molecular mechanisms of a self-destruction pathway. J Cell Biol (2012) 2.26

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest (2011) 2.25

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18

Role for glia in synaptogenesis. Glia (2004) 2.15

The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One (2010) 2.06

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron (2005) 2.06

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99

Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods (2009) 1.98

Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res (2009) 1.94

Development of a method for the purification and culture of rodent astrocytes. Neuron (2011) 1.92

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature (2012) 1.92

Between the sheets: a molecular sieve makes myelin membranes. Dev Cell (2011) 1.87

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86

Importance of intrinsic mechanisms in cell fate decisions in the developing rat retina. Neuron (2003) 1.86

Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell (2012) 1.81

Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing. J Neurosci (2011) 1.77

Neuronal pentraxins mediate synaptic refinement in the developing visual system. J Neurosci (2006) 1.71

Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit. Neuron (2011) 1.67

A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proc Natl Acad Sci U S A (2011) 1.65

Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol (2009) 1.62

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab (2008) 1.59

Analysis of microRNA knockouts in mice. Hum Mol Genet (2010) 1.59

LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nat Med (2002) 1.57

Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem (2009) 1.53

Dicer1 is required for differentiation of the mouse male germline. Biol Reprod (2008) 1.52

MicroRNAs and endocrine biology. J Endocrinol (2005) 1.47

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol (2013) 1.45

A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci (2008) 1.44

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42

Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nat Genet (2009) 1.38

Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37

A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci (2013) 1.35

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature (2010) 1.35

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. Proc Natl Acad Sci U S A (2010) 1.34

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31

An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci (2004) 1.27

Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci (2008) 1.23

An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener (2007) 1.22

A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation. J Neurosci (2007) 1.22

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol (2013) 1.17

Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol (2012) 1.16