Published in J Cell Mol Med on April 01, 2009
Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene. Nucleic Acids Res (2010) 1.36
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A (2009) 1.29
Transcriptional networks driving enhancer function in the CFTR gene. Biochem J (2012) 1.00
A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology (2010) 0.99
Molecular mechanisms controlling CFTR gene expression in the airway. J Cell Mol Med (2012) 0.97
Novel regulatory mechanisms for the CFTR gene. Biochem Soc Trans (2009) 0.94
Nucleosome mapping across the CFTR locus identifies novel regulatory factors. Nucleic Acids Res (2013) 0.92
Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells. Epigenetics (2014) 0.91
Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. Nucleic Acids Res (2015) 0.88
Nuclear RNA sequencing of the mouse erythroid cell transcriptome. PLoS One (2012) 0.88
Cell-type specificity of ChIP-predicted transcription factor binding sites. BMC Genomics (2012) 0.87
Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer. Mol Cell Biol (2013) 0.85
Nucleosome occupancy reveals regulatory elements of the CFTR promoter. Nucleic Acids Res (2011) 0.85
Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression. Biochim Biophys Acta (2009) 0.84
Multiple mechanisms influence regulation of the cystic fibrosis transmembrane conductance regulator gene promoter. Am J Respir Cell Mol Biol (2009) 0.83
The cystic fibrosis gene: a molecular genetic perspective. Cold Spring Harb Perspect Med (2013) 0.81
Genomic approaches for the discovery of CFTR regulatory elements. Transcription (2012) 0.81
Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population. PLoS One (2014) 0.78
Transcriptional targeting in the airway using novel gene regulatory elements. Am J Respir Cell Mol Biol (2012) 0.78
Chromatin Dynamics in the Regulation of CFTR Expression. Genes (Basel) (2015) 0.78
Analysis of long-range interactions in primary human cells identifies cooperative CFTR regulatory elements. Nucleic Acids Res (2015) 0.77
CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet (2015) 0.77
A balance between activating and repressive histone modifications regulates cystic fibrosis transmembrane conductance regulator (CFTR) expression in vivo. Epigenetics (2014) 0.77
HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability. J Exp Clin Cancer Res (2016) 0.75
Deep resequencing of CFTR in 762 F508del homozygotes reveals clusters of non-coding variants associated with cystic fibrosis disease traits. Hum Genome Var (2016) 0.75
A Leader Intron of a Soybean Elongation Factor 1A (eEF1A) Gene Interacts with Proximal Promoter Elements to Regulate Gene Expression in Synthetic Promoters. PLoS One (2016) 0.75
HNF1 regulates critical processes in the human epididymis epithelium. Mol Cell Endocrinol (2016) 0.75
Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function. Biochim Biophys Acta (2016) 0.75
Investigating the role of introns in the regulation of regenerating gene 1 expression. Oncol Lett (2014) 0.75
The ENCODE (ENCyclopedia Of DNA Elements) Project. Science (2004) 38.24
Capturing chromosome conformation. Science (2002) 23.93
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc (2007) 6.28
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Methods (2006) 6.25
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet (2006) 5.62
The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet (2003) 5.54
CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol (1994) 4.62
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science (1987) 4.59
Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst (1977) 4.35
The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev (2004) 4.04
Spatial organization of gene expression: the active chromatin hub. Chromosome Res (2003) 3.91
Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays. Methods Enzymol (2006) 3.53
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell (2008) 3.24
Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J (2007) 2.99
Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc Natl Acad Sci U S A (1991) 2.82
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J (1991) 2.19
Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation. J Cell Biol (1987) 2.03
Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol (2001) 1.93
Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest (1994) 1.86
The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin. J Biol Chem (1991) 1.70
Expression of the cystic fibrosis gene in adult human lung. J Clin Invest (1994) 1.70
Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J (2001) 1.55
Expression of the cystic fibrosis gene in human development. Development (1991) 1.45
Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene. Mol Cell Biol (1997) 1.37
An element in intron 1 of the CFTR gene augments intestinal expression in vivo. Hum Mol Genet (2001) 1.33
A regulatory element in intron 1 of the cystic fibrosis transmembrane conductance regulator gene. J Biol Chem (1996) 1.31
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J (2004) 1.25
Characterization of DNASE I hypersensitive sites in the 120kb 5' to the CFTR gene. Biochem Biophys Res Commun (1995) 1.23
Characterization of the cystic fibrosis transmembrane conductance regulator promoter region. Chromatin context and tissue-specificity. J Biol Chem (1993) 1.22
CTCF mediates insulator function at the CFTR locus. Biochem J (2007) 1.16
Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene. Eur J Biochem (2002) 1.14
Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene. J Biol Chem (1991) 1.14
Multiple potential intragenic regulatory elements in the CFTR gene. Genomics (2000) 1.11
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter. J Biol Chem (1996) 1.10
Transcription of cystic fibrosis transmembrane conductance regulator requires a CCAAT-like element for both basal and cAMP-mediated regulation. J Biol Chem (1995) 1.05
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity. Proc Natl Acad Sci U S A (1995) 1.03
FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha. Oncogene (2002) 1.03
Analysis of DNase-I-hypersensitive sites at the 3' end of the cystic fibrosis transmembrane conductance regulator gene (CFTR). Biochem J (1999) 1.03
Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4. Am J Physiol (1999) 0.99
The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element. Biochem J (2007) 0.97
Binding of serum response factor to cystic fibrosis transmembrane conductance regulator CArG-like elements, as a new potential CFTR transcriptional regulation pathway. Nucleic Acids Res (2005) 0.96
Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. J Biol Chem (2006) 0.90
The cystic fibrosis transmembrane conductance regulator as a marker of human pancreatic duct development. Gastroenterology (1997) 0.89
A cultured human renal epithelioid cell line responsive to vasoactive intestinal peptide. Exp Physiol (1990) 0.88
Characterization of the aldolase B intronic enhancer. J Biol Chem (1998) 0.87
NF-kappaB activation is involved in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) by interleukin-1beta. J Biol Chem (2001) 0.85
CFTR intron 1 increases luciferase expression driven by CFTR 5'-flanking DNA in a yeast artificial chromosome. Genomics (2000) 0.81
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
DNase I sensitivity QTLs are a major determinant of human expression variation. Nature (2012) 6.17
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93
RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Methods (2013) 4.85
F-Seq: a feature density estimator for high-throughput sequence tags. Bioinformatics (2008) 4.77
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res (2010) 4.69
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res (2011) 4.43
Extended lung cancer incidence follow-up in the Mayo Lung Project and overdiagnosis. J Natl Cancer Inst (2006) 4.39
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res (2013) 3.61
DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb Protoc (2010) 3.54
Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays. Methods Enzymol (2006) 3.53
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010) 3.24
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet (2006) 2.62
Dissecting the regulatory architecture of gene expression QTLs. Genome Biol (2012) 2.51
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20
The phenotypic consequences of CFTR mutations. Ann Hum Genet (2003) 2.09
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. Genome Res (2012) 1.99
UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery. Genes Dev (2004) 1.88
Predicting cell-type-specific gene expression from regions of open chromatin. Genome Res (2012) 1.78
Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res (2013) 1.69
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. Elife (2013) 1.63
Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab (2008) 1.55
Site-specific silencing of regulatory elements as a mechanism of X inactivation. Cell (2012) 1.54
Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. Cancer Res (2007) 1.34
Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip). Methods Mol Biol (2009) 1.33
Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy. Hum Mol Genet (2002) 1.32
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans (2013) 1.30
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A (2009) 1.29
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J (2004) 1.25
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. PLoS Genet (2013) 1.23
Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet (2012) 1.22
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci (2009) 1.22
An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells. Nucleic Acids Res (2009) 1.19
High-resolution mapping of open chromatin in the rice genome. Genome Res (2011) 1.19
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity (2010) 1.17
Distinct properties of cell-type-specific and shared transcription factor binding sites. Mol Cell (2013) 1.16
CTCF mediates insulator function at the CFTR locus. Biochem J (2007) 1.16
MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene. Biochem J (2011) 1.15
Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity. Genome Biol (2012) 1.15
Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene. Eur J Biochem (2002) 1.14
Gene expression during normal and FSHD myogenesis. BMC Med Genomics (2011) 1.12
The CFTR gene and regulation of its expression. Pediatr Pulmonol (2005) 1.07
The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes. Mol Cell Biol (2012) 1.06
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res (2013) 1.05
Alternative 5' exons of the CFTR gene show developmental regulation. Hum Mol Genet (2003) 1.00
Transcriptional networks driving enhancer function in the CFTR gene. Biochem J (2012) 1.00
Early de novo DNA methylation and prolonged demethylation in the muscle lineage. Epigenetics (2013) 1.00
Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. Hum Mol Genet (2006) 1.00
MUC6 mucin expression inhibits tumor cell invasion. Exp Cell Res (2011) 0.99
The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins. FEBS J (2005) 0.98
Molecular mechanisms controlling CFTR gene expression in the airway. J Cell Mol Med (2012) 0.97
Allele-specific and heritable chromatin signatures in humans. Hum Mol Genet (2010) 0.96
N-Glycosylation of the MUC1 mucin in epithelial cells and secretions. Glycobiology (2006) 0.95
A T3 allele in the CFTR gene exacerbates exon 9 skipping in vas deferens and epididymal cell lines and is associated with Congenital Bilateral Absence of Vas Deferens (CBAVD). Hum Mutat (2005) 0.95
Novel regulatory mechanisms for the CFTR gene. Biochem Soc Trans (2009) 0.94
The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. Histochem Cell Biol (2010) 0.93
Nucleosome mapping across the CFTR locus identifies novel regulatory factors. Nucleic Acids Res (2013) 0.92
Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC. PLoS One (2011) 0.92
Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage. PLoS Genet (2012) 0.92
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS One (2012) 0.91
Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients. Cell Physiol Biochem (2009) 0.90
H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites. Genome Med (2012) 0.90
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts. J Cyst Fibros (2004) 0.89
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA. Mol Cell Biol (2011) 0.89
The contribution of tandem repeat number to the O-glycosylation of mucins. Glycobiology (2002) 0.89
Atypical 5' splice sites cause CFTR exon 9 to be vulnerable to skipping. Am J Hum Genet (2002) 0.88
A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function. Thorax (2011) 0.88
Transcriptional regulation of CFTR gene expression. Front Biosci (Elite Ed) (2012) 0.88
Evaluation of gene targeting by homologous recombination in ovine somatic cells. Mol Reprod Dev (2003) 0.87
Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes. PLoS Genet (2012) 0.87
Quantitative methods for the analysis of CFTR transcripts/splicing variants. J Cyst Fibros (2004) 0.86
DNA polymorphisms in potential regulatory elements of the CFTR gene alter transcription factor binding. Hum Genet (2002) 0.86
DNA methylation and differentiation: HOX genes in muscle cells. Epigenetics Chromatin (2013) 0.86
Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer. Mol Cell Biol (2013) 0.85
DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2. Nucleic Acids Res (2009) 0.85
Nucleosome occupancy reveals regulatory elements of the CFTR promoter. Nucleic Acids Res (2011) 0.85
A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function. Biol Reprod (2013) 0.85
Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells. PLoS One (2013) 0.85
Hispanic Infants with cystic fibrosis show low CFTR mutation detection rates in the Illinois newborn screening program. J Genet Couns (2012) 0.84
Validation of an improved pediatric weight estimation strategy. J Pediatr Pharmacol Ther (2013) 0.84
Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression. Biochim Biophys Acta (2009) 0.84
Multiple mechanisms influence regulation of the cystic fibrosis transmembrane conductance regulator gene promoter. Am J Respir Cell Mol Biol (2009) 0.83