Published in PLoS One on May 21, 2009
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol (2010) 2.35
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J Virol (2011) 1.22
Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A (2014) 1.11
Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein. J Virol (2012) 1.05
Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009. PLoS One (2011) 1.00
Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627. PLoS One (2012) 0.98
Identification of novel conserved functional motifs across most Influenza A viral strains. Virol J (2011) 0.94
Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectin. J Virol (2012) 0.89
Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection. J Virol (2011) 0.88
Predicting host tropism of influenza A virus proteins using random forest. BMC Med Genomics (2014) 0.84
Genetic content of Influenza H3N2 vaccine seeds. PLoS Curr (2010) 0.84
The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997 (H5N1) restricts the replication of reassortant ribonucleoprotein complexes [corrected]. PLoS One (2012) 0.81
Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review. Ecohealth (2015) 0.80
Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position. Virology (2014) 0.80
A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity. Influenza Other Respir Viruses (2013) 0.79
The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus. J Virol (2015) 0.78
Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses. PLoS One (2013) 0.78
Amino acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens. J Virol (2014) 0.76
Aging and Loss of Circulating 17β-Estradiol Alters the Alternative Splicing of ERβ in the Female Rat Brain. Endocrinology (2015) 0.76
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles. Sci Rep (2016) 0.75
DNA intercalator stimulates influenza transcription and virus replication. Virol J (2011) 0.75
Recombinant influenza virus with a pandemic H2N2 polymerase complex has a higher adaptive potential than one with seasonal H2N2 polymerase complex. J Gen Virol (2015) 0.75
Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes. BMC Genomics (2016) 0.75
Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol (2001) 21.17
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43
Characterization of the 1918 influenza virus polymerase genes. Nature (2005) 15.73
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci U S A (2000) 12.16
Rescue of influenza A virus from recombinant DNA. J Virol (1999) 11.54
Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol (2005) 10.77
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol (1989) 10.63
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol (1993) 10.22
Initial genetic characterization of the 1918 "Spanish" influenza virus. Science (1997) 10.17
A novel influenza A virus mitochondrial protein that induces cell death. Nat Med (2001) 9.90
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med (2002) 9.47
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet (2002) 8.70
Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J Virol (2005) 7.88
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A (2005) 7.39
Rates of evolutionary change in viruses: patterns and determinants. Nat Rev Genet (2008) 6.79
PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med (2006) 5.94
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol (2006) 5.26
A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog (2007) 4.99
Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A (2001) 4.93
H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog (2008) 4.79
Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res (2005) 4.41
Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proc Natl Acad Sci U S A (2004) 4.00
Biologic importance of neuraminidase stalk length in influenza A virus. J Virol (1993) 3.51
Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J Virol (2001) 3.43
A single gene determines the host range of influenza virus. Nature (1977) 3.43
Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog (2008) 3.37
Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses. J Gen Virol (2000) 3.19
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature (2008) 3.06
Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation. Eur J Biochem (2003) 2.74
The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature (2008) 2.74
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus. Proc Natl Acad Sci U S A (2008) 2.72
Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells. Virology (2007) 2.49
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. J Virol (2004) 2.49
Influenza virus susceptibility and resistance to oseltamivir. Antivir Ther (2007) 2.46
Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions. J Virol (2005) 2.45
Molecular and antigenic evolution and geographical spread of H5N1 highly pathogenic avian influenza viruses in western Africa. J Gen Virol (2007) 2.41
Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses. PLoS Pathog (2008) 2.38
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex. J Virol (2004) 2.30
Host restriction of avian influenza viruses at the level of the ribonucleoproteins. Annu Rev Microbiol (2008) 2.29
Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol (2007) 2.20
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. J Virol (2005) 2.19
Retracted The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res (2004) 2.15
Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J Virol (2007) 2.04
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. J Virol (2006) 1.93
Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell (2005) 1.93
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits. J Virol (2006) 1.93
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes. Virology (1989) 1.92
Fine mapping of the subunit binding sites of influenza virus RNA polymerase. Microbiol Immunol (2002) 1.90
Efficient formation of influenza virus-like particles: dependence on the expression levels of viral proteins. J Gen Virol (1999) 1.89
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure. Nucleic Acids Res (1996) 1.89
Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Res (2007) 1.77
Molecular assembly of the influenza virus RNA polymerase: determination of the subunit-subunit contact sites. J Gen Virol (1996) 1.77
In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex. J Virol (2005) 1.73
Functional association between viral and cellular transcription during influenza virus infection. Rev Med Virol (2006) 1.65
Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics (2008) 1.64
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II. J Virol (2007) 1.64
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev (2005) 1.57
The impact of influenza and influenza-like illness on productivity and healthcare resource utilization in a working population. Occup Med (Lond) (1998) 1.56
Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses. J Virol (2008) 1.55
A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA. J Virol (1995) 1.52
The challenge of avian influenza to the veterinary community. Avian Pathol (2006) 1.51
Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses. Antiviral Res (2008) 1.47
Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells. J Virol (2005) 1.47
Influenza: interspecies transmission and emergence of new pandemics. FEMS Immunol Med Microbiol (1997) 1.46
NP, PB1, and PB2 viral genes contribute to altered replication of H5N1 avian influenza viruses in chickens. J Virol (2008) 1.34
Influenza virus inhibits RNA polymerase II elongation. Virology (2006) 1.30
Large-scale isolation of Cajal bodies from HeLa cells. Mol Biol Cell (2002) 1.20
Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes Cells (2007) 1.11
Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5' end of the viral intron. J Gen Virol (2005) 1.09
Apoptosis by influenza viruses correlates with efficiency of viral mRNA synthesis. Virus Res (2001) 1.05
Primary isolation of influenza viruses at 33 degrees C. Lancet (1963) 1.05
Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain. FEBS Lett (2007) 0.98
Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus. Virus Res (2008) 0.89
Alterations of the stalk of the influenza virus neuraminidase: deletions and insertions. Virus Res (1993) 0.88
Effects of single-point amino acid substitutions on the structure and function neuraminidase proteins in influenza A virus. Microbiol Immunol (2008) 0.88
Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Res (2008) 0.86
Deviation from the random distribution pattern of influenza A virus gene segments in reassortants produced under non-selective conditions. Arch Virol (2008) 0.84
Sabotage of antiviral signaling and effectors by influenza viruses. Biol Chem (2008) 0.82
Studies on the temperature sensitivity of influenza A virus reassortants nonpathogenic for chicken. Virus Res (1986) 0.79
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature (2009) 17.96
Oseltamivir resistance during treatment of influenza A (H5N1) infection. N Engl J Med (2005) 15.53
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol (2005) 9.13
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol (2003) 9.09
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One (2008) 6.98
Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38
A highly conserved neutralizing epitope on group 2 influenza A viruses. Science (2011) 5.66
Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40
Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet (2004) 5.32
Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol (2004) 5.17
Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med (2006) 5.14
Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002. Avian Pathol (2004) 5.08
Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J Clin Microbiol (2005) 5.04
Lung pathology of fatal severe acute respiratory syndrome. Lancet (2003) 5.02
Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol (2013) 4.98
Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A (2009) 4.36
Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans. J Clin Virol (2009) 4.10
Rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (SARS). Clin Chem (2003) 4.03
Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification. Clin Chem (2005) 3.75
Gain-of-function experiments on H7N9. Science (2013) 3.67
Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis (2003) 3.66
MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis (2014) 3.64
The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature (2013) 3.60
H5N1 outbreaks and enzootic influenza. Emerg Infect Dis (2006) 3.49
Highly conserved protective epitopes on influenza B viruses. Science (2012) 3.47
Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis (2013) 3.35
Influenza A H5N1 replication sites in humans. Emerg Infect Dis (2005) 3.21
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J (2005) 3.14
Influenza-associated hospitalization in a subtropical city. PLoS Med (2006) 3.07
Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China. J Virol (2002) 2.97
Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet (2005) 2.82
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis (2006) 2.76
Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol (2005) 2.56
Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med (2007) 2.53
Evolving complexities of influenza virus and its receptors. Trends Microbiol (2008) 2.49
MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis (2014) 2.47
Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir Res (2007) 2.45
Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia. J Infect Dis (2005) 2.43
Long-term evolution and transmission dynamics of swine influenza A virus. Nature (2011) 2.39
Avian flu: Gain-of-function experiments on H7N9. Nature (2013) 2.32
Influenza: emergence and control. J Virol (2004) 2.31
Pause on avian flu transmission research. Science (2012) 2.24
Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses. PLoS Pathog (2008) 2.14
Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerg Infect Dis (2009) 2.13
Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol (2010) 2.11
Characterization of a human H5N1 influenza A virus isolated in 2003. J Virol (2005) 2.09
Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad Sci U S A (2011) 2.06
Early diagnosis of SARS coronavirus infection by real time RT-PCR. J Clin Virol (2003) 2.05
Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci U S A (2011) 2.04
Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China. Clin Infect Dis (2005) 2.03
Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol (2005) 1.93
Effect of interventions on influenza A (H9N2) isolation in Hong Kong's live poultry markets, 1999-2005. Emerg Infect Dis (2007) 1.82
Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002. Emerg Infect Dis (2007) 1.79
Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. J Virol (2005) 1.76
Avian coronavirus in wild aquatic birds. J Virol (2011) 1.73
Vaccination of chickens against H5N1 avian influenza in the face of an outbreak interrupts virus transmission. Avian Pathol (2004) 1.72
Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol (2010) 1.71
Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures. J Virol (2013) 1.68
Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract. Am J Pathol (2010) 1.67
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J Immunol (2009) 1.66
Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J Virol (2007) 1.65
H5N1 influenza viruses in Lao People's Democratic Republic. Emerg Infect Dis (2006) 1.64
Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection. PLoS Pathog (2013) 1.62
Neurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001. J Virol (2003) 1.62
Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008. Emerg Infect Dis (2009) 1.61
Multiple sublineages of influenza A virus (H5N1), Vietnam, 2005-2007. Emerg Infect Dis (2008) 1.59
Comment on "Seroevidence for H5N1 influenza infections in humans: meta-analysis". Science (2012) 1.58
MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model. Magn Reson Med (2007) 1.57
The nsp9 replicase protein of SARS-coronavirus, structure and functional insights. Structure (2004) 1.55
Detection of SARS coronavirus in patients with severe acute respiratory syndrome by conventional and real-time quantitative reverse transcription-PCR assays. Clin Chem (2004) 1.55
Gene flow and competitive exclusion of avian influenza A virus in natural reservoir hosts. Virology (2009) 1.54
Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J Virol (2008) 1.53
Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution. Virol J (2010) 1.53
Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells. Blood (2005) 1.52