Published in Proc Natl Acad Sci U S A on November 15, 1991
Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics (2007) 2.89
Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury. Mol Psychiatry (2009) 1.12
ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation. Mol Med (1999) 0.98
Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study. J Comp Neurol (2009) 0.96
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray. Front Neural Circuits (2014) 0.78
Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons. Neuroscience (2013) 0.78
The nerve growth factor 35 years later. Science (1987) 7.25
Molecular cloning and expression of brain-derived neurotrophic factor. Nature (1989) 3.90
Purification of a new neurotrophic factor from mammalian brain. EMBO J (1982) 3.68
The axon reaction: a review of the principal features of perikaryal responses to axon injury. Int Rev Neurobiol (1971) 2.96
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science (1990) 2.91
Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J (1990) 2.77
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature (1991) 2.70
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature (1990) 2.69
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J (1990) 2.54
Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine. Proc Natl Acad Sci U S A (1969) 2.30
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron (1990) 2.22
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci U S A (1977) 2.11
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron (1991) 2.10
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron (1991) 2.02
Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A (1990) 1.94
Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. EMBO J (1985) 1.93
Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci U S A (1990) 1.76
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron (1991) 1.74
Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science (1990) 1.71
Primary structure and biological activity of a novel human neurotrophic factor. Neuron (1990) 1.65
Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system. Proc Natl Acad Sci U S A (1986) 1.56
Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc Natl Acad Sci U S A (1991) 1.52
Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain Res (1984) 1.51
Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons. Proc Natl Acad Sci U S A (1986) 1.47
Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol (1990) 1.37
Expression of the beta-nerve growth factor gene in hippocampal neurons. Science (1988) 1.35
The physiological function of nerve growth factor in the central nervous system: comparison with the periphery. Rev Physiol Biochem Pharmacol (1987) 1.33
Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra. Brain Res (1979) 1.28
Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons. Neuron (1989) 1.28
Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress. Proc Natl Acad Sci U S A (1989) 1.19
NGF gene expression in actively growing brain glia. J Neurosci (1991) 1.10
Cloning and expression of a cDNA encoding a novel human neurotrophic factor. FEBS Lett (1990) 1.10
Distribution of neuronal receptors for nerve growth factor in the rat. J Neurosci (1986) 1.08
Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system--I. Forebrain. Neuroscience (1990) 1.03
Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus. Brain Res Mol Brain Res (1991) 1.02
Expression of NGF and NGF receptor mRNAs in the developing brain: evidence for local delivery and action of NGF. Exp Neurol (1989) 1.00
Preferential neurotoxicity of colchicine for granule cells of the dentate gyrus of the adult rat. Proc Natl Acad Sci U S A (1980) 0.98
Effects of two mitosis inhibitors (colchicine and vinblastine) on the distribution and axonal transport of noradrenaline storage particles, studied by fluorescence and electron microscopy. Z Zellforsch Mikrosk Anat (1971) 0.97
LRF producing cells of the mammalian hypothalamus. A fluorescent antibody study. Z Zellforsch Mikrosk Anat (1973) 0.95
Effects of central nervous system lesions on the expression of galanin: a comparative in situ hybridization and immunohistochemical study. Proc Natl Acad Sci U S A (1990) 0.87
Mitosis inhibitors and axonal transport. Int Rev Cytol Suppl (1978) 0.86
Nerve growth factor mRNA-containing cells are distributed within regions of cholinergic neurons in the rat basal forebrain. J Comp Neurol (1991) 0.86
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A (1998) 4.14
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science (1984) 3.63
Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons. J Pharm Pharmacol (1973) 3.54
Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron (1993) 3.44
Peptidergic neurones. Nature (1980) 3.36
Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand (1982) 3.25
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. Science (1984) 3.24
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci U S A (2000) 3.04
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A (1998) 2.91
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res (1975) 2.72
Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine. Eur J Pharmacol (1969) 2.61
Immunohistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat. Neuroscience (1976) 2.56
Controls of RNA splicing and termination in the major late adenovirus transcription unit. Nature (1981) 2.49
Substance p: localization in the central nervous system and in some primary sensory neurons. Science (1975) 2.33
Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine. Eur J Pharmacol (1969) 2.26
Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol (1977) 2.26
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron (1990) 2.22
Learning deficit in BDNF mutant mice. Eur J Neurosci (1997) 2.20
Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry (1992) 2.15
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci U S A (1977) 2.11
Synthesis of a structural adenovirus polypeptide in the absence of viral DNA replication. Virology (1978) 2.09
Evidence for dopamine receptor stimulation by apomorphine. J Pharm Pharmacol (1967) 2.08
Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell (1985) 2.06
Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res (1984) 2.05
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron (1991) 2.02
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla. Neuroscience (1978) 2.01
Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci U S A (1980) 2.00
Distribution of substance P-like immunoreactivity in the central nervous system of the rat--I. Cell bodies and nerve terminals. Neuroscience (1978) 1.99
Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol (1985) 1.97
Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci U S A (1982) 1.95
Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A (1990) 1.94
Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line. Proc Natl Acad Sci U S A (1978) 1.94
Adenovirus early gene products may control viral mRNA accumulation and translation in vivo. Cell (1981) 1.93
Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat. Neuroscience (1976) 1.92
High nitric oxide production in human paranasal sinuses. Nat Med (1995) 1.90
Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol (1998) 1.87
Synthesis and genomic site for an adenovirus type 2 early glycoprotein. J Mol Biol (1980) 1.82
Climate change and the integrity of science. Science (2010) 1.80
Myelinated nerve fibres in the CNS. Prog Neurobiol (1993) 1.79
Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol (1993) 1.78
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron (1991) 1.74
Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia (2007) 1.73
Flare and itch induced by substance P in human skin. J Invest Dermatol (1978) 1.72
A study of 136 cases of adder bite treated in Swedish hospitals during one year. Acta Med Scand (1981) 1.71
Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons. Science (1995) 1.70
Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2. J Virol (1978) 1.69
Control of adenovirus early gene expression: posttranscriptional control mediated by both viral and cellular gene products. Mol Cell Biol (1981) 1.68
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett (1983) 1.68
Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience (1978) 1.67
Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence. Proc Natl Acad Sci U S A (1980) 1.66
A galanin-like peptide in the central nervous system and intestine of the rat. Neurosci Lett (1984) 1.63
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell (1992) 1.62
An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse. Nature (1982) 1.60
Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system. Proc Natl Acad Sci U S A (1986) 1.56
On the occurrence of substance P-containing fibers in sympathetic ganglia: immunohistochemical evidence. Brain Res (1977) 1.55
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience (1992) 1.52
Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience (2007) 1.51
Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man. Peptides (1984) 1.51
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes. Neurosci Lett (1986) 1.49
Gene and mRNA for precursor polypeptide VI from adenovirus type 2. J Virol (1981) 1.49
In vitro studies on central and peripheral monoamine neurons at the ultrastructural level. Z Zellforsch Mikrosk Anat (1968) 1.48
Distribution of galaninlike immunoreactivity in the rat central nervous system. J Comp Neurol (1986) 1.46
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat Biotechnol (1998) 1.44
Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. Proc Natl Acad Sci U S A (1997) 1.44
Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J Neurosci (1986) 1.43
Pharmacological properties of 1-(3'5'-diisobutyryloxy-phenyl)-2-(t-butylamino)-ethanolhydrochloride (KWD 2058), a new sympathomimetic bronchodilator. Acta Pharmacol Toxicol (Copenh) (1974) 1.42
Peptide neurons in the vagus, splanchnic and sciatic nerves. Acta Physiol Scand (1978) 1.42
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature (1995) 1.41
Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides (1987) 1.41
Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience (1984) 1.41
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol (1997) 1.40
Immunohistochemical evidence for the localization of somatostatin--like immunoreactivity in a cell population of the pancreatic islets. Med Biol (1974) 1.40
Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci (1998) 1.40
Purification and characterization of an early glycoprotein from adenovirus type 2-infected cells. J Virol (1979) 1.39
Effect of apomorphine on the GABA turnover in the DA cell group rich area of the mesencephalon. Evidence for the involvement of an inhibitory gabergic feedback control of the ascending DA neurons. Neurosci Lett (1975) 1.38
Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia. Science (1974) 1.38
Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively. Development (1997) 1.38
Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. Proc Natl Acad Sci U S A (1987) 1.37
Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol (1990) 1.37
Proximal tubule Na+-K+-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am J Physiol (1988) 1.36
2 new groups of selective stimulants of adrenergic beta-receptors. Experientia (1969) 1.36
Expression of the beta-nerve growth factor gene in hippocampal neurons. Science (1988) 1.35
A quantitative study on the nigro-neostriatal dopamine neuron system in the rat. Acta Physiol Scand (1967) 1.35
Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig. Regul Pept (1985) 1.35
Purification of a native membrane-associated adenovirus tumor antigen. J Virol (1982) 1.35
Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1-cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol Suppl (Copenh) (1975) 1.34
Growth-dependent synthesis of c-myc-encoded proteins: early stimulation by serum factors in synchronized mouse 3T3 cells. Mol Cell Biol (1985) 1.34
Evidence for a central noradrenaline receptor stimulation by clonidine. Life Sci (1970) 1.33
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res (1995) 1.32
Citalopram toxicity. Lancet (1997) 1.32
Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol (1993) 1.32
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med (1999) 1.31
Suppressed epileptogenesis in BDNF mutant mice. Exp Neurol (1995) 1.30
Histochemical amd biochemical effects of diethyldithiocarbamate on tissue catecholamines. J Pharm Pharmacol (1966) 1.29
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol (1998) 1.29
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc Natl Acad Sci U S A (2001) 1.29
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci U S A (1992) 1.29