Induction of HoxB transcription by retinoic acid requires actin polymerization.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMC 2719572)

Published in Mol Biol Cell on May 28, 2009

Authors

Carmelo Ferrai1, Gabriela Naum-Onganía, Elena Longobardi, Martina Palazzolo, Andrea Disanza, Victor M Diaz, Massimo P Crippa, Giorgio Scita, Francesco Blasi

Author Affiliations

1: San Raffaele Scientific Institute and University Vita Salute San Raffaele, 20132 Milan, Italy.

Articles citing this

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev (2011) 1.67

Nuclear functions of actin. Cold Spring Harb Perspect Biol (2010) 1.55

Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development. Science (2013) 1.13

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates. Dev Dyn (2013) 1.07

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination. Development (2011) 1.02

Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression. Small GTPases (2014) 0.98

Understanding the regulatory and transcriptional complexity of the genome through structure. Genome Res (2013) 0.97

Co-transcriptional nuclear actin dynamics. Nucleus (2012) 0.95

Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux. Front Genet (2012) 0.95

Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins. Cell Mol Life Sci (2012) 0.87

Actin, actin-binding proteins, and actin-related proteins in the nucleus. Histochem Cell Biol (2016) 0.86

Nuclear actin and transcriptional activation. Commun Integr Biol (2011) 0.86

PSF: nuclear busy-body or nuclear facilitator? Wiley Interdiscip Rev RNA (2015) 0.85

Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. Mol Syst Biol (2012) 0.82

Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.81

Nuclear F-actin enhances the transcriptional activity of β-catenin by increasing its nuclear localization and binding to chromatin. Histochem Cell Biol (2016) 0.80

Transcriptome analysis of spermatogenically regressed, recrudescent and active phase testis of seasonally breeding wall lizards Hemidactylus flaviviridis. PLoS One (2013) 0.79

Involvement of the SATB1/F-actin complex in chromatin reorganization during active cell death. Int J Mol Med (2014) 0.77

Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1. PLoS One (2010) 0.76

Nuclear Actin in Development and Transcriptional Reprogramming. Front Genet (2017) 0.75

Three-dimensional apoptotic nuclear behavior analyzed by means of Field Emission in Lens Scanning Electron Microscope. Eur J Histochem (2015) 0.75

Articles cited by this

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Hox genes in vertebrate development. Cell (1994) 9.27

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30

Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science (2008) 5.48

Mechanism of actin-based motility. Science (2001) 5.04

Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science (2007) 4.89

Long-range directional movement of an interphase chromosome site. Curr Biol (2006) 3.96

PSF and p54(nrb)/NonO--multi-functional nuclear proteins. FEBS Lett (2002) 3.06

Actin-dependent intranuclear repositioning of an active gene locus in vivo. J Cell Biol (2007) 2.93

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature (1994) 2.76

Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem (2001) 2.74

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature (1990) 2.73

Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol (2006) 2.52

Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol (2004) 2.49

Is actin a transcription initiation factor for RNA polymerase B? EMBO J (1984) 2.49

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nat Cell Biol (2000) 2.46

Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes. Cell (1984) 2.45

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development (2001) 2.33

Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development (1999) 2.21

Actin up in the nucleus. Nat Rev Mol Cell Biol (2004) 2.13

Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol (1999) 2.01

Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations. J Cell Biol (2006) 1.98

The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J (1998) 1.93

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92

A role for beta-actin in RNA polymerase III transcription. Genes Dev (2004) 1.82

Actin and hnRNP U cooperate for productive transcription by RNA polymerase II. Nat Struct Mol Biol (2005) 1.75

Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev (1997) 1.74

An actin-myosin complex on actively transcribing genes. Exp Cell Res (2004) 1.74

Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70

Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development (2000) 1.69

Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev (2008) 1.63

Molecular functions of nuclear actin in transcription. J Cell Biol (2006) 1.59

Eliminating zebrafish pbx proteins reveals a hindbrain ground state. Dev Cell (2002) 1.52

Actin and myosin as transcription factors. Curr Opin Genet Dev (2006) 1.48

Actin in the nucleus: what form and what for? J Struct Biol (2002) 1.46

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol (2006) 1.46

Tracking down the different forms of nuclear actin. Trends Cell Biol (2006) 1.29

A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. J Biol Chem (2007) 1.28

Retinoids and Hox genes. FASEB J (1996) 1.20

Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway. Neuron (1998) 1.20

Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. Development (1999) 1.18

Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol (2005) 1.17

Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites. Mol Cell Biol (2005) 1.14

Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development (2004) 1.12

The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol (2007) 1.05

p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity. Mol Cell Biol (2007) 1.04

Actin in transcription. Actin is required for transcription by all three RNA polymerases in the eukaryotic cell nucleus. EMBO Rep (2005) 0.93

Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice. Dev Dyn (2002) 0.91

A transcription-dependent micrococcal nuclease-resistant fragment of the urokinase-type plasminogen activator promoter interacts with the enhancer. J Biol Chem (2007) 0.89

Purification of the Prep1 interactome identifies novel pathways regulated by Prep1. Proteomics (2007) 0.83

The function of actin in gene transcription. Histol Histopathol (2007) 0.83

Articles by these authors

The effect of telithromycin in acute exacerbations of asthma. N Engl J Med (2006) 5.35

Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. Lancet Infect Dis (2012) 4.62

Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med (2004) 4.58

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell (2008) 4.47

Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol (2004) 4.04

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J (2004) 3.31

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol (2007) 3.01

Predicting Mycobacterium tuberculosis in patients with community-acquired pneumonia. Eur Respir J (2013) 2.69

Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest (2015) 2.66

Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol (2005) 2.63

Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol (2002) 2.57

Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature (2004) 2.39

Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest (2009) 2.34

Anxiety and depression in COPD patients: The roles of gender and disease severity. Respir Med (2006) 2.28

The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev (2003) 2.22

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination. Eur Respir J (2013) 2.20

Impact of age and comorbidity on cause and outcome in community-acquired pneumonia. Chest (2013) 2.19

Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol (2004) 2.19

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol (2005) 2.16

A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med (2007) 2.08

The European Respiratory Society plans its future: the 2013-2018 strategic plan. Eur Respir J (2014) 2.02

IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe (2009) 2.01

Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis (2011) 1.97

Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax (2013) 1.92

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell (2006) 1.92

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91

Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood (2004) 1.83

A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78

uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol (2004) 1.71

Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing. J Cell Biol (2006) 1.70

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat Cell Biol (2004) 1.69

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol (2002) 1.60

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol (2011) 1.55

Assessment of severity of ICU-acquired pneumonia and association with etiology. Crit Care Med (2014) 1.53

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions. EMBO J (2003) 1.52

Acute myocardial infarction in hospitalized patients with community-acquired pneumonia. Clin Infect Dis (2008) 1.49

Bronchiectasis: an update. Clin Respir J (2009) 1.48

Validation of predictors of adverse outcomes in hospital-acquired pneumonia in the ICU. Crit Care Med (2013) 1.48

Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections. Pediatr Infect Dis J (2005) 1.47

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol (2006) 1.46

Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. J Cell Sci (2006) 1.45

Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index. Eur Respir J (2013) 1.45

Tuberculosis elimination: theory and practice in Europe. Eur Respir J (2014) 1.42

Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: a European perspective. Thorax (2013) 1.41

ICU-acquired pneumonia with or without etiologic diagnosis: a comparison of outcomes. Crit Care Med (2013) 1.41

Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PLoS One (2009) 1.41

Nuclear myosin VI enhances RNA polymerase II-dependent transcription. Mol Cell (2006) 1.39

Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J Biol Chem (2005) 1.33

Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol (2007) 1.30

Electronic cigarettes. A position statement of the forum of international respiratory societies. Am J Respir Crit Care Med (2014) 1.29

Poised transcription factories prime silent uPA gene prior to activation. PLoS Biol (2010) 1.28

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (2005) 1.25

Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization. J Biol Chem (2002) 1.25

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell (2008) 1.23

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21

Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Rep (2013) 1.21

The urokinase receptor as an entertainer of signal transduction. Front Biosci (Landmark Ed) (2009) 1.21

Eps8 in the midst of GTPases. Int J Biochem Cell Biol (2002) 1.20

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. J Clin Invest (2009) 1.19

Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. J Biol Chem (2003) 1.19

Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol (2005) 1.17

Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1. Dev Biol (2006) 1.17

Guidelines for empiric antimicrobial prescribing in community-acquired pneumonia. Chest (2004) 1.17

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15

MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription. Blood (2004) 1.15

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration. Mol Biol Cell (2005) 1.15

Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites. Mol Cell Biol (2005) 1.14

The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion. J Cell Sci (2004) 1.14

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet (2009) 1.14

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14

Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development (2004) 1.12

The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem (2009) 1.12

Sos-mediated activation of rac1 by p66shc. J Cell Biol (2006) 1.10

F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation. Cell Signal (2009) 1.09

WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium. J Biol Chem (2005) 1.09

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1. Cancer Res (2012) 1.08

Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia. J Cereb Blood Flow Metab (2012) 1.08