Published in Front Genet on September 28, 2012
Transcription through enhancers suppresses their activity in Drosophila. Epigenetics Chromatin (2013) 0.89
Nucleoside modifications in the regulation of gene expression: focus on tRNA. Cell Mol Life Sci (2016) 0.85
An autoregulatory pathway establishes the definitive chromatin conformation at the pit-1 locus. Mol Cell Biol (2015) 0.78
Administration of genetic expression by multi-task proteins and long-range action. Front Genet (2013) 0.75
The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol (2016) 0.75
SV40 transcription terminators stabilize the activity of regulatory elements in Drosophila melanogaster. Dokl Biochem Biophys (2015) 0.75
Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci (2017) 0.75
Functional organization of the white gene enhancer in Drosophila melanogaster. Dokl Biochem Biophys (2015) 0.75
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Genome-wide mapping of in vivo protein-DNA interactions. Science (2007) 64.92
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Capturing chromosome conformation. Science (2002) 23.93
Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell (1981) 20.72
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell (1987) 15.79
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature (1980) 14.11
A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35
Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods (2009) 10.17
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Variation in transcription factor binding among humans. Science (2010) 9.33
Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays. Nat Methods (2006) 8.52
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res (2006) 7.72
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet (2009) 6.99
Long-range chromatin regulatory interactions in vivo. Nat Genet (2002) 6.55
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Genomic views of distant-acting enhancers. Nature (2009) 6.27
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
DNase I sensitivity QTLs are a major determinant of human expression variation. Nature (2012) 6.17
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01
Next-generation genomics: an integrative approach. Nat Rev Genet (2010) 5.88
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77
The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet (2003) 5.54
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
Unsupervised pattern discovery in human chromatin structure through genomic segmentation. Nat Methods (2012) 4.89
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
Remote control of gene transcription. Hum Mol Genet (2005) 4.80
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol (2004) 4.67
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell (1984) 4.42
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31
A decade of 3C technologies: insights into nuclear organization. Genes Dev (2012) 4.25
Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08
The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev (2004) 4.04
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
Long-range directional movement of an interphase chromosome site. Curr Biol (2006) 3.96
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions. Genome Res (2011) 3.57
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell (2008) 3.24
Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell (2011) 3.20
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A (2011) 3.18
Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Nat Genet (2012) 2.94
Actin-dependent intranuclear repositioning of an active gene locus in vivo. J Cell Biol (2007) 2.93
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature (1984) 2.93
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta (2010) 2.86
Importance of globin gene order for correct developmental expression. Genes Dev (1991) 2.85
Intragenic enhancers act as alternative promoters. Mol Cell (2012) 2.85
Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature (1984) 2.83
Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol (2010) 2.80
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters. Nat Struct Mol Biol (2011) 2.79
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell (1996) 2.77
Large-scale discovery of enhancers from human heart tissue. Nat Genet (2011) 2.70
The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev (2003) 2.65
Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards? J Cell Biochem (2005) 2.64
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev (2010) 2.47
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
Transcription factories are nuclear subcompartments that remain in the absence of transcription. Genes Dev (2008) 2.41
H3K4 tri-methylation provides an epigenetic signature of active enhancers. EMBO J (2011) 2.38
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20
Transcription of the hypersensitive site HS2 enhancer in erythroid cells. Proc Natl Acad Sci U S A (1992) 2.20
The human beta-globin locus control region can silence as well as activate gene expression. Mol Cell Biol (2005) 2.19
Epigenomic enhancer profiling defines a signature of colon cancer. Science (2012) 2.15
Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell (2011) 2.14
Cohesin: genomic insights into controlling gene transcription and development. Curr Opin Genet Dev (2011) 2.12
A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region. EMBO J (1996) 2.12
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res (2012) 2.09
Control of embryonic stem cell lineage commitment by core promoter factor, TAF3. Cell (2011) 2.00
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. Genome Res (2012) 1.99
DNA methylation status predicts cell type-specific enhancer activity. EMBO J (2011) 1.98
Sequentially acting Sox transcription factors in neural lineage development. Genes Dev (2011) 1.97
HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter. Genome Res (2012) 1.96
Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster. Nucleic Acids Res (1986) 1.90
Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation (2006) 5.58
The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet (2003) 5.54
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J Neurosci (2003) 4.72
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A (2003) 4.28
The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev (2004) 4.04
Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One (2010) 3.96
Spatial organization of gene expression: the active chromatin hub. Chromosome Res (2003) 3.91
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J Cell Biol (2005) 3.54
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. Dev Cell (2006) 2.99
RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell (2009) 2.76
Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol (2002) 2.75
3C technology: analyzing the spatial organization of genomic loci in vivo. Methods Enzymol (2004) 2.58
GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J (2005) 2.56
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev (2010) 2.47
Rab6 regulates transport and targeting of exocytotic carriers. Dev Cell (2007) 2.32
EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. Mol Biol Cell (2005) 2.19
GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells. Immunity (2003) 2.15
Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol (2004) 2.12
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol (2005) 2.11
The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev (2003) 2.10
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol (2008) 2.06
X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator. Cell (2008) 1.98
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab (2013) 1.87
Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol (2006) 1.81
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat Genet (2002) 1.81
Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends. J Cell Biol (2008) 1.68
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. EMBO J (2003) 1.65
Novel binding partners of Ldb1 are required for haematopoietic development. Development (2006) 1.63
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions. Nat Protoc (2013) 1.46
Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis. Mol Cell (2012) 1.46
High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology. Nat Methods (2009) 1.44
Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One (2013) 1.42
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol (2011) 1.42
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J (2011) 1.41
Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice. J Biol Chem (2007) 1.34
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes Dev (2005) 1.33
Beta-globin regulation and long-range interactions. Adv Genet (2008) 1.31
Three-dimensional organization of gene expression in erythroid cells. Curr Top Dev Biol (2008) 1.30
Distal angiogenesis: a new concept for lung vascular morphogenesis. Am J Physiol Lung Cell Mol Physiol (2004) 1.28
A generic tool for biotinylation of tagged proteins in transgenic mice. Transgenic Res (2005) 1.26
Functional and comparative analysis of globin loci in pufferfish and humans. Blood (2002) 1.23
Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell (2012) 1.23
Inter-chromosomal gene regulation in the mammalian cell nucleus. Curr Opin Genet Dev (2007) 1.22
A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res (2003) 1.20
Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle. Mol Cell Biol (2008) 1.18
Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein. J Biol Chem (2002) 1.16
HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers. J Clin Invest (2014) 1.14
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol (2009) 1.14
Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited. Mol Cell (2002) 1.14
A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J (2002) 1.13
A systems approach to analyze transcription factors in mammalian cells. Methods (2010) 1.10
CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin (2010) 1.06
Dynamic regulation of Gata factor levels is more important than their identity. Blood (2007) 1.06
Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice. Atherosclerosis (2008) 1.05
History-dependent catastrophes regulate axonal microtubule behavior. Curr Biol (2010) 1.05
Transposition of the Drosophila hydei Minos transposon in the mouse germ line. Genomics (2003) 1.03
Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions. Cell Motil Cytoskeleton (2009) 1.03
Optimal use of tandem biotin and V5 tags in ChIP assays. BMC Mol Biol (2009) 1.02
The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties. PLoS One (2009) 1.02
Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island. BMC Dev Biol (2007) 1.00
Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes. EMBO Rep (2002) 1.00
HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells. EMBO J (2003) 0.99
Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood (2003) 0.99
Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. J Biol Chem (2002) 0.99
Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding. J Neurosci (2011) 0.99
Genome-wide DNA methylation profiling of non-small cell lung carcinomas. Epigenetics Chromatin (2012) 0.98
Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads. Methods Mol Biol (2006) 0.97
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics (2012) 0.97
The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner. Epigenetics Chromatin (2012) 0.97
Persistent gamma-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences. Blood (2003) 0.96
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest (2010) 0.95
Acute elevation of plasma PLTP activity strongly increases pre-existing atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 0.95
Gata1 regulates dendritic-cell development and survival. Blood (2007) 0.95
The human desmin locus: gene organization and LCR-mediated transcriptional control. Genomics (2006) 0.95
Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol (2007) 0.95
Transcription regulation by distal enhancers: who's in the loop? Transcription (2012) 0.95
Fetal globin expression is regulated by Friend of Prmt1. Blood (2010) 0.94
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice. Blood (2013) 0.94
Tagged mutagenesis by efficient Minos-based germ line transposition. Mol Cell Biol (2010) 0.93
Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol (2010) 0.92
Hypoxia-inducible factor 2α plays a critical role in the formation of alveoli and surfactant. Am J Respir Cell Mol Biol (2012) 0.92
A hanging drop culture method to study terminal erythroid differentiation. Exp Hematol (2005) 0.91
Elevated expression of phospholipid transfer protein in bone marrow derived cells causes atherosclerosis. PLoS One (2008) 0.91
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity. Haematologica (2012) 0.91
Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas. J Thorac Oncol (2013) 0.91
Cell autonomy of the mouse claw paw mutation. Dev Biol (2004) 0.90
Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. Mol Ther (2005) 0.89
Homotypic signalling regulates Gata1 activity in the erythroblastic island. Development (2004) 0.89
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. Mol Cell Biol (2012) 0.88
A Role for PML in Innate Immunity. Genes Cancer (2011) 0.88
Canonical Wnt signaling induces a primitive endoderm metastable state in mouse embryonic stem cells. Stem Cells (2013) 0.88
Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses. J Virol (2003) 0.88
Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy. J Thorac Oncol (2012) 0.88
Locus-specific proteomics by TChP: targeted chromatin purification. Cell Rep (2013) 0.87