Published in Carcinogenesis on May 29, 2009
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Rif1 regulates the replication timing domains on the human genome. EMBO J (2012) 1.87
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Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell (2014) 1.04
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Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget (2016) 0.75
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Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell (2008) 2.28
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene (2007) 1.83
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol (2004) 1.71
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Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol Cancer Ther (2004) 1.56
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Overexpression of DNA repair genes is associated with metastasis: a new hypothesis. Mutat Res (2008) 1.18
Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res (2008) 1.10
53BP1 is a positive regulator of the BRCA1 promoter. Cell Cycle (2005) 1.06
The DNA damage response during an unperturbed S-phase. DNA Repair (Amst) (2007) 1.05
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Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature (2010) 10.09
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med (2014) 9.25
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol (2005) 6.40
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35
The genome of a songbird. Nature (2010) 5.90
Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
Global diversity in the human salivary microbiome. Genome Res (2009) 5.16
Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res (2010) 4.79
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol (2011) 4.56
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
DNA binding site sequence directs glucocorticoid receptor structure and activity. Science (2009) 4.48
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution. Nat Neurosci (2007) 4.28
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J (2002) 4.13
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09
Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Exchange-coupled nanocomposite magnets by nanoparticle self-assembly. Nature (2002) 3.71
MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res (2006) 3.66
A burst of segmental duplications in the genome of the African great ape ancestor. Nature (2009) 3.63
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Evolutionary toggling of the MAPT 17q21.31 inversion region. Nat Genet (2008) 3.42
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res (2007) 3.37
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw (2009) 3.25
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet (2010) 3.15
A role for small RNAs in DNA double-strand break repair. Cell (2012) 3.15
Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle (2009) 3.14
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
Circulating suPAR in two cohorts of primary FSGS. J Am Soc Nephrol (2012) 2.83
Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol (2006) 2.76
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J Invest Dermatol (2007) 2.59
Identification of hepatitis C virus NS5A inhibitors. J Virol (2010) 2.58
Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. Mol Cell (2004) 2.55
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol (2009) 2.54
Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients. J Infect Dis (2012) 2.53
Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res (2011) 2.53
Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med (2003) 2.50
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother (2010) 2.50
The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta (2009) 2.50
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A (2006) 2.49
Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver. Hepatology (2012) 2.47
N-Benzyl-2-(2,6-dichloro-phen-oxy)-acetamide. Acta Crystallogr Sect E Struct Rep Online (2008) 2.36
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res (2011) 2.36
GADD45A does not promote DNA demethylation. PLoS Genet (2008) 2.36
Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet (2011) 2.35
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol (2006) 2.32
Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052. Hepatology (2012) 2.29
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell (2008) 2.28
Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO J (2009) 2.28
Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer. Lab Invest (2005) 2.23
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
True versus reported waiting times for valvular aortic stenosis surgery. Can J Cardiol (2006) 2.21
Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20
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Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol (2008) 2.19
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. J Biol Chem (2005) 2.19
New bioinformatics resources for metabolomics. Pac Symp Biocomput (2007) 2.19
Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol (2002) 2.19
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood (2007) 2.18
Effects of vacuum-assisted closure on wound microcirculation: an experimental study. Asian J Surg (2005) 2.14
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12
Significant improvement in short-term mortality in women undergoing coronary artery bypass surgery (1991 to 2004). J Am Coll Cardiol (2007) 2.11
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations. Hepatology (2011) 2.10