The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMID 19483232)

Published in J Bone Joint Surg Br on June 01, 2009

Authors

K Rajesparan1, L C Biant, M Ahmad, R E Field

Author Affiliations

1: The Elective Orthopaedic Centre, Epsom, Surrey, UK. krajesparan@hotmail.com

Associated clinical trials:

The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery (TXA) | NCT02684851

Role of Topical Tranexamic Acid in Total Hip Arthroplasty (TXA) | NCT01866943

Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population (TAHFT) | NCT03923959

Articles citing this

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta Orthop (2011) 1.18

One intraoperative dose of tranexamic Acid for patients having primary hip or knee arthroplasty. Clin Orthop Relat Res (2010) 1.13

Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty. Clin Orthop Relat Res (2014) 0.90

Topical versus systemic tranexamic acid after total knee and hip arthroplasty: A meta-analysis of randomized controlled trials. Medicine (Baltimore) (2016) 0.83

Tranexamic acid reduces allogenic transfusion in revision hip arthroplasty. Clin Orthop Relat Res (2011) 0.82

Preoperative erythropoietin alpha reduces postoperative transfusions in THA and TKA but may not be cost-effective. Clin Orthop Relat Res (2015) 0.82

Blood loss and transfusion rate in short stem hip arthroplasty. A comparative study. Int Orthop (2016) 0.79

Tranexamic Acid Reduces Hidden Blood Loss in Patients Undergoing Total Knee Arthroplasty: A Comparative Study and Meta-Analysis. Med Sci Monit (2016) 0.78

Assessing the impact of fracture pattern on transfusion requirements in hip fractures. Eur J Trauma Emerg Surg (2016) 0.78

Safety and Efficacy of Tranexamic Acid in Total Knee Arthroplasty. Med Sci Monit (2015) 0.78

Tranexamic acid for reducing blood transfusions in arthroplasty interventions: a cost-effective practice. Eur J Orthop Surg Traumatol (2013) 0.77

A questionnaire-based survey investigating the current use of tranexamic acid in traumatic haemorrhage and elective hip and knee arthroplasty. JRSM Open (2014) 0.75

The effect of different dose regimens of tranexamic acid in reducing blood loss during hip surgery. Indian J Anaesth (2017) 0.75

The effect of the grade of surgeon on blood loss in fractured neck-of-femur surgery. Eur J Orthop Surg Traumatol (2012) 0.75

Articles by these authors

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell (1998) 5.06

A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br (2003) 4.16

Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci (2003) 3.62

Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1. Science (1995) 3.28

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest (1993) 2.97

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A (1996) 2.65

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem (1997) 2.26

Alopecia universalis associated with a mutation in the human hairless gene. Science (1998) 2.23

Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg Br (2010) 2.13

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ (2001) 2.09

Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells. J Exp Med (1998) 2.03

Expression of an Arabidopsis cryptochrome gene in transgenic tobacco results in hypersensitivity to blue, UV-A, and green light. Proc Natl Acad Sci U S A (1995) 1.96

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J (1999) 1.95

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem (1997) 1.86

Arabidopsis cryptochrome 1 is a soluble protein mediating blue light-dependent regulation of plant growth and development. Plant J (1996) 1.86

111In-labeled nonspecific immunoglobulin scanning in the detection of focal infection. N Engl J Med (1989) 1.76

Bronchoscopically induced bleeding. A summary of nine years' Cleveland clinic experience and review of the literature. Chest (1991) 1.74

The outcome of primary total hip and knee arthroplasty in patients aged 80 years or more. J Bone Joint Surg Br (2011) 1.72

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Drug-induced lung disease. Cleve Clin J Med (2001) 1.63

Introducing care pathway commissioning to primary dental care: measuring performance. Br Dent J (2011) 1.61

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J Biol Chem (1998) 1.52

Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. Nat Genet (1998) 1.51

Significance of perioperative blood transfusions in patients undergoing resection of stage I and II non-small-cell lung cancers. Chest (1992) 1.49

Amyloidosis and pleural disease. Chest (1990) 1.48

Patient expectations of arthroplasty of the hip and knee. J Bone Joint Surg Br (2012) 1.43

The effects of steroid therapy on pulmonary hypertension secondary to fibrosing mediastinitis. Cleve Clin J Med (1990) 1.39

Wegener's granulomatosis. Immunomicroscopic and ultrastructural study of four cases. Arch Pathol Lab Med (1990) 1.39

The role of ultrasound in the diagnosis and follow-up of early inflammatory arthritis. Clin Radiol (2011) 1.39

Effect of the timing of tourniquet release on postoperative hematoma formation: an experimental animal study. Plast Reconstr Surg (1989) 1.38

A genetic analysis of HIV-1 from Punjab, India reveals the presence of multiple variants. AIDS (1995) 1.38

Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res (1999) 1.36

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci U S A (2000) 1.36

Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy. J Infect Dis (1999) 1.35

Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. Hum Mol Genet (1998) 1.34

A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. Am J Hum Genet (1998) 1.32

Projection of the thoracic pedicle and its morphometric analysis. Spine (Phila Pa 1976) (1997) 1.30

Insecticide-treated plastic tarpaulins for control of malaria vectors in refugee camps. Med Vet Entomol (2002) 1.29

Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2012) 1.23

A gene for universal congenital alopecia maps to chromosome 8p21-22. Am J Hum Genet (1998) 1.23

Interpretation of patient-reported outcomes for hip and knee replacement surgery: identification of thresholds associated with satisfaction with surgery. J Bone Joint Surg Br (2012) 1.22

Predictors of gastrointestinal complications after conventional and beating heart coronary surgery. Surgeon (2003) 1.22

Immunization coverage in three districts of North West Frontier Province (NWFP). J Pak Med Assoc (1999) 1.22

X-chromosomally inherited split-hand/split-foot anomaly in a Pakistani kindred. Hum Genet (1987) 1.22

Ultrasonic debridement of root canals: acoustic streaming and its possible role. J Endod (1987) 1.21

Mapping of the gene for X-chromosomal split-hand/split-foot anomaly to Xq26-q26.1. Hum Genet (1993) 1.21

Preemptive analgesia II: recent advances and current trends. Can J Anaesth (2001) 1.21

Prenatal nicotine exposure modifies behavior of mice through early development. Pharmacol Biochem Behav (1998) 1.21

Preparation and properties of Nalpha-9-fluorenylmethyloxycarbonylamino acids bearing tert.-butyl side chain protection. Int J Pept Protein Res (1980) 1.20

Preemptive analgesia I: physiological pathways and pharmacological modalities. Can J Anaesth (2001) 1.19

Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19

Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76  TeV. Phys Rev Lett (2012) 1.19

Long-term trends in the Oxford knee score following total knee replacement. Bone Joint J (2013) 1.18

Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family. Genomics (1999) 1.17

ELISPOT assays provide reproducible results among different laboratories for T-cell immune monitoring--even in hands of ELISPOT-inexperienced investigators. J Immunotoxicol (2009) 1.16

Clinical experience of patellar fracture fixation using metal wire or non-absorbable polyester--a study of 37 cases. Injury (2001) 1.14

Acute left ventricular failure after large volume pericardiocentesis. Clin Cardiol (2003) 1.12

Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene (1996) 1.12

Unusual cardiac complications of Wegener's granulomatosis. Chest (1985) 1.11

CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J Biol Chem (1999) 1.11

Biosocial perspective of consanguineous marriages in rural and urban Swat, Pakistan. J Biosoc Sci (1996) 1.10

Search for a W' or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7  TeV. Phys Rev Lett (2012) 1.10

The Metasul metal-on-metal articulation in primary total hip replacement: clinical and radiological results at ten years. J Bone Joint Surg Br (2008) 1.10

The relationship between obesity and the age at which hip and knee replacement is undertaken. J Bone Joint Surg Br (2008) 1.09

Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Phys Rev Lett (2012) 1.09

Assessment of left-to-right shunt and left ventricular function in isolated ventricular septal defect. Echocardiographic study. Br Heart J (1979) 1.08

Search for supersymmetry at the LHC in events with jets and missing transverse energy. Phys Rev Lett (2011) 1.08

Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation. Oncogene (2012) 1.07

Search for stopped Gluinos in pp collisions at square root s=7 TeV. Phys Rev Lett (2011) 1.07

Live three dimensional echocardiography in evaluation of left ventricular to right atrial shunt (Gerbode defect). Heart (2006) 1.07

Genetic organization of the Pantoea stewartii subsp. stewartii hrp gene cluster and sequence analysis of the hrpA, hrpC, hrpN, and wtsE operons. Mol Plant Microbe Interact (2001) 1.06

Pulmonary vasculitis (Wegener's granulomatosis). Immunohistochemical study of T and B cell markers. Am J Med (1983) 1.06

Socioeconomic status affects the early outcome of total hip replacement. J Bone Joint Surg Br (2011) 1.06

Reliability and validity of Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) with proposed revisions. J Oral Rehabil (2010) 1.05

Biochemical characterization of Taenia hydatigena cysticerci from goats and pigs. J Helminthol (1989) 1.05

The effects of age on patient-reported outcome measures in total knee replacements. Bone Joint J (2013) 1.05

Rabies in man handling infected calf. Lancet (1991) 1.05

Measurement of the Υ1S, Υ2S, and Υ3S polarizations in pp collisions at sqrt[s] = 7 TeV. Phys Rev Lett (2013) 1.05

Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome). Clin Genet (2002) 1.04

MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis. Clin Radiol (2007) 1.04

Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem (1998) 1.03

Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects. Circulation (1990) 1.03

A locus for autosomal recessive hypodontia with associated dental anomalies maps to chromosome 16q12.1. Am J Hum Genet (1998) 1.03

Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I. Am J Physiol Regul Integr Comp Physiol (2000) 1.03

Subcutaneous phaeohyphomycosis. J Infect (1993) 1.02

The pulmonary manifestations of systemic lupus erythematosus. Semin Arthritis Rheum (1985) 1.02

Activation of fibrinolysis by apolipoproteins of high density lipoproteins in man. Thromb Res (1985) 1.01

Biomechanics of the Birmingham hip resurfacing arthroplasty. J Bone Joint Surg Br (2006) 1.00

Total hip arthroplasty: to cement or not to cement the acetabular socket? A critical review of the literature. Arch Orthop Trauma Surg (2011) 1.00

Ultrasonic debridement of root canals: an insight into the mechanisms involved. J Endod (1987) 1.00

Dexamethasone and bacterial meningitis in Pakistan. Arch Dis Child (1996) 0.99

Socioeconomic status affects the Oxford knee score and short-form 12 score following total knee replacement. Bone Joint J (2013) 0.99

Measurement of the polarization of W bosons with large transverse momenta in W + jets events at the LHC. Phys Rev Lett (2011) 0.99

Ototoxicity due to cis-diamminedichloroplatinum in the treatment of ovarian cancer: influence of dosage and schedule of administration. Ear Hear (1991) 0.99

Measurement of the inclusive jet cross section in pp collisions at √s = 7 TeV. Phys Rev Lett (2011) 0.98

Familial spontaneous pneumothorax and HLA antigens. Chest (1980) 0.98

What is a good patient reported outcome after total hip replacement? Osteoarthritis Cartilage (2010) 0.98