Published in J Biol Chem on April 24, 1998
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci U S A (2001) 3.19
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease. Am J Pathol (2004) 2.19
Targeted cell killing by reconstituted caspases. Proc Natl Acad Sci U S A (2007) 1.61
Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci (2004) 1.48
Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure. J Cell Biol (2011) 1.34
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia (2006) 1.24
Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. Dev Biol (2010) 1.22
Tumor-specific gene expression using the survivin promoter is further increased by hypoxia. Gene Ther (2004) 1.11
L2' loop is critical for caspase-7 active site formation. Protein Sci (2009) 1.11
Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol (2010) 1.10
Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors. EMBO J (1999) 1.06
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. J Cell Biol (2003) 0.99
Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response. Cell Death Differ (2013) 0.93
Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway. Evid Based Complement Alternat Med (2010) 0.90
New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases. Cell Death Dis (2013) 0.88
The short prodomain influences caspase-3 activation in HeLa cells. Biochem J (2000) 0.88
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis (2013) 0.85
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun (2017) 0.84
The effect of aloe emodin-encapsulated nanoliposome-mediated r-caspase-3 gene transfection and photodynamic therapy on human gastric cancer cells. Cancer Med (2015) 0.81
An Engineered Split Intein for Photoactivated Protein Trans-Splicing. PLoS One (2015) 0.80
Molecular determinants involved in activation of caspase 7. Biosci Rep (2011) 0.78
Synchronous apoptosis in established tumors leads to the induction of adaptive immunity. Oncoimmunology (2013) 0.78
Apoptosis-inducing effect of recombinant Caspase-3 expressed by constructed eukaryotic vector on gastric cancer cell line SGC7901. World J Gastroenterol (2003) 0.78
Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evid Based Complement Alternat Med (2011) 0.76
Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells. BMC Urol (2017) 0.75
Functional chimeras of human immunodeficiency virus type 1 Gp120 and influenza A virus (H3) hemagglutinin. J Virol (2005) 0.75
Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis. Cell Death Differ (2017) 0.75
A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses. Cell Death Differ (2016) 0.75
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. J Biol Chem (2017) 0.75
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci U S A (2017) 0.75
Effect of sulglycotide on the apoptotic processes associated with indomethacin-induced gastric mucosal injury. Inflammopharmacology (1998) 0.75
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A (1993) 10.36
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 7.74
Human ICE/CED-3 protease nomenclature. Cell (1996) 7.11
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (2001) 6.62
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med (2000) 5.72
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem (1994) 5.51
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell (1998) 5.06
Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron (2001) 4.62
Bactericidal activity of photocatalytic TiO(2) reaction: toward an understanding of its killing mechanism. Appl Environ Microbiol (1999) 4.18
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ (2006) 3.77
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature (1997) 3.70
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69
Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci (2003) 3.62
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A (1996) 3.53
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Structural clues to prion replication. Science (1994) 3.43
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem (2001) 3.37
Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1. Science (1995) 3.28
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1998) 3.23
Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol (2000) 3.05
Structural basis of caspase-7 inhibition by XIAP. Cell (2001) 2.99
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci U S A (1997) 2.99
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest (1993) 2.97
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature (1999) 2.95
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci (1999) 2.92
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (1998) 2.89
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature (1999) 2.88
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem (1999) 2.76
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A (1996) 2.65
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res (1995) 2.56
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene (2008) 2.47
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J (1996) 2.46
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ (2002) 2.42
Recovery of a virulent strain of newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation. Virology (2000) 2.39
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol (2001) 2.27
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem (1997) 2.26
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem (2001) 2.25
Alopecia universalis associated with a mutation in the human hairless gene. Science (1998) 2.23
Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J (2000) 2.13
POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol (1999) 2.11
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ (2001) 2.09
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem (1996) 2.07
Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci U S A (2008) 2.06
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J (2001) 2.06
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol (2000) 2.04
c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol Cell Biol (2000) 2.03
Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells. J Exp Med (1998) 2.03
Femtosecond and subfemtosecond x-ray pulses from a self-amplified spontaneous-emission-based free-electron laser. Phys Rev Lett (2004) 2.02
Initiation of Apaf-1 translation by internal ribosome entry. Oncogene (2000) 2.01
A Chinese triconodont mammal and mosaic evolution of the mammalian skeleton. Nature (1999) 2.00
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97
Nucleotides and two functional states of hsp90. J Biol Chem (1997) 1.96
Measurements and simulations of ultralow emittance and ultrashort electron beams in the linac coherent light source. Phys Rev Lett (2009) 1.96
Expression of an Arabidopsis cryptochrome gene in transgenic tobacco results in hypersensitivity to blue, UV-A, and green light. Proc Natl Acad Sci U S A (1995) 1.96
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem (1999) 1.96
Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis. Hum Mol Genet (1996) 1.93
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry (1993) 1.93
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem (2000) 1.89
Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke (1997) 1.89
Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene (2008) 1.88
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res (2001) 1.87
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr. Am J Physiol Endocrinol Metab (2001) 1.86
Arabidopsis cryptochrome 1 is a soluble protein mediating blue light-dependent regulation of plant growth and development. Plant J (1996) 1.86
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem (1997) 1.86
Diet and basal cell carcinoma of the skin in a prospective cohort of men. Am J Clin Nutr (2000) 1.85
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res (1999) 1.80
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ (2006) 1.77
111In-labeled nonspecific immunoglobulin scanning in the detection of focal infection. N Engl J Med (1989) 1.76