Published in Chem Biol Interact on January 21, 2009
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol (2003) 3.60
The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses (2009) 3.45
Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol (2009) 2.00
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses. Proc Natl Acad Sci U S A (2008) 1.66
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem (2007) 1.59
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J Biol Chem (2003) 1.48
Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol (2009) 1.39
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim Biophys Acta (2006) 1.31
Hyperforin inhibits cancer invasion and metastasis. Cancer Res (2004) 1.27
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev (2010) 1.26
An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery? Angew Chem Int Ed Engl (2011) 1.26
Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod (2011) 1.19
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc Natl Acad Sci U S A (2011) 1.16
Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. Phytother Res (2004) 1.16
Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun (2007) 1.09
Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse? J Med Chem (2004) 1.06
A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun (2004) 1.05
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues. FEBS Lett (2002) 1.05
Protective activation of the endocannabinoid system during ischemia in dopamine neurons. Neurobiol Dis (2006) 1.04
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain (2012) 1.03
Ischemic neuroprotection by TRPV1 receptor-induced hypothermia. J Cereb Blood Flow Metab (2012) 1.03
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin. J Agric Food Chem (2009) 1.02
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther (2004) 1.01
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact (2008) 1.01
Oligomeric acylphloroglucinols from myrtle (Myrtus communis). J Nat Prod (2002) 0.99
SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol (2008) 0.99
Receptor agonism and antagonism of dietary bitter compounds. J Neurosci (2011) 0.99
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. Mol Pharmacol (2003) 0.98
Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo. Eur J Immunol (2002) 0.97
Spices: the savory and beneficial science of pungency. Rev Physiol Biochem Pharmacol (2013) 0.96
Tandem beta-alkylation-alpha-arylation of amines by carbolithiation and rearrangement of N-carbamoyl enamines (vinyl ureas). J Am Chem Soc (2010) 0.93
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine. Prostaglandins Leukot Essent Fatty Acids (2009) 0.93
Plant volatiles: production, function and pharmacology. Nat Prod Rep (2011) 0.93
Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs. Curr Drug Targets (2011) 0.93
Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation. Biochem Pharmacol (2007) 0.93
Novel approach to study oxidative stability of extra virgin olive oils: importance of alpha-tocopherol concentration. J Agric Food Chem (2002) 0.92
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study. Bioorg Med Chem Lett (2007) 0.92
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids. Angew Chem Int Ed Engl (2007) 0.92
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Mol Nutr Food Res (2009) 0.91
Ligustilide: a novel TRPA1 modulator. Pflugers Arch (2011) 0.91
Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds. Planta Med (2009) 0.91
Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochem Pharmacol (2004) 0.91
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem (2009) 0.91
Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead. J Med Chem (2003) 0.90
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene. Bioorg Med Chem Lett (2009) 0.90
Flavonoid characterization and antioxidant activity of hydroalcoholic extracts from Achillea ligustica All. J Pharm Biomed Anal (2009) 0.89
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain (2013) 0.89
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways. J Immunol (2004) 0.89
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem (2004) 0.87
N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor. J Med Chem (2002) 0.87
Anti-inflammatory and vascularprotective properties of 8-prenylapigenin. Eur J Pharmacol (2009) 0.87
Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida. Fitoterapia (2013) 0.86
Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety. J Nat Prod (2002) 0.86
Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochem Pharmacol (2010) 0.86
Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. Chem Biol Interact (2006) 0.86
Chemical composition and effect on intestinal Caco-2 cell viability and lipid profile of fixed oil from Cynomorium coccineum L. Food Chem Toxicol (2012) 0.86
Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells. Biochem Pharmacol (2009) 0.86
Antioxidant activity of capsinoids. J Agric Food Chem (2002) 0.85
A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis. J Neuroimmune Pharmacol (2012) 0.85
Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential. Eur J Nutr (2003) 0.85
The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination. J Med Chem (2005) 0.84
Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes. J Pharmacol Exp Ther (2006) 0.84
Daphnane-type diterpene orthoesters and their biological activities. Mini Rev Med Chem (2002) 0.84
Antioxidant activity of oligomeric acylphloroglucinols from Myrtus communis L. Free Radic Res (2003) 0.84
Extraction and separation of volatile and fixed oils from berries of Laurus nobilis L. by Supercritical CO2. Molecules (2008) 0.83
Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds. J Pharmacol Exp Ther (2005) 0.83
Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. Chem Phys Lipids (2008) 0.83
Selective analysis of phenolic compounds in propolis by HPLC-MS/MS. Phytochem Anal (2008) 0.83
Umbellulone modulates TRP channels. Pflugers Arch (2011) 0.83
Oxyhomologation of the amide bond potentiates neuroprotective effects of the endolipid N-palmitoylethanolamine. J Pharmacol Exp Ther (2006) 0.83
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol. Mol Nutr Food Res (2010) 0.83