Published in Trends Biochem Sci on June 24, 2009
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nat Rev Neurosci (2010) 3.14
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell (2010) 2.83
Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat Cell Biol (2011) 1.58
Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+ release. J Cell Mol Med (2012) 1.40
Drosophila melanogaster as a model to study drug addiction. Hum Genet (2012) 1.39
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J (2011) 1.32
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J (2013) 1.31
Initiating and growing an axon. Cold Spring Harb Perspect Biol (2010) 1.24
AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol (2010) 1.22
Protein phosphorylation in neurodegeneration: friend or foe? Front Mol Neurosci (2014) 1.15
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Hum Mol Genet (2011) 1.10
Pseudomonas aeruginosa exotoxin Y is a promiscuous cyclase that increases endothelial tau phosphorylation and permeability. J Biol Chem (2012) 1.08
The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. J Cell Sci (2014) 1.04
Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells. PLoS One (2012) 1.01
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol (2013) 1.01
DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity. Cell Death Differ (2011) 0.99
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling. J Cell Biol (2011) 0.99
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol Biol Cell (2012) 0.98
Salt stress-induced disassembly of Arabidopsis cortical microtubule arrays involves 26S proteasome-dependent degradation of SPIRAL1. Plant Cell (2011) 0.97
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem (2012) 0.95
MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis. J Endocrinol (2013) 0.93
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet (2010) 0.93
Emergent complexity of the cytoskeleton: from single filaments to tissue. Adv Phys (2013) 0.92
LKB1 and AMP-activated protein kinase: regulators of cell polarity. Genes Cells (2012) 0.91
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila. Nat Commun (2012) 0.88
Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity. J Biol Chem (2012) 0.87
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep (2016) 0.86
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philos Trans R Soc Lond B Biol Sci (2013) 0.85
Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration. Curr Biol (2012) 0.84
Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells. PLoS One (2013) 0.84
Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis. Semin Cell Dev Biol (2016) 0.84
Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Int J Cancer (2015) 0.84
TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes. PLoS One (2011) 0.83
Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK. Pflugers Arch (2014) 0.83
The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95). J Biol Chem (2012) 0.83
Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis. Spermatogenesis (2012) 0.82
A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle. Dev Cell (2013) 0.82
Notch signalling in adult neurons: a potential target for microtubule stabilization. Ther Adv Neurol Disord (2013) 0.82
Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease. J Biol Chem (2013) 0.82
MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta Neuropathol Commun (2014) 0.81
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J (2014) 0.81
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS One (2015) 0.80
Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. Sci Rep (2015) 0.79
Emerging modes of PINK1 signaling: another task for MARK2. Front Mol Neurosci (2014) 0.79
A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines. Bioarchitecture (2011) 0.78
Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. J Proteome Res (2013) 0.77
Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr (2013) 0.77
Tubulin binds to the cytoplasmic loop of TRESK background K⁺ channel in vitro. PLoS One (2014) 0.77
Neuroprotective Effects Against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton. J Exp Neurosci (2016) 0.76
PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein. Cell Adh Migr (2012) 0.76
Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression. Curr Opin Neurobiol (2014) 0.76
Structural insight into the mechanism of synergistic autoinhibition of SAD kinases. Nat Commun (2015) 0.76
Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation. Mol Biol Res Commun (2014) 0.75
Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genom Data (2015) 0.75
Back to the tubule: microtubule dynamics in Parkinson's disease. Cell Mol Life Sci (2016) 0.75
Fission yeast mtr1p regulates interphase microtubule cortical dwell-time. Biol Open (2014) 0.75
Polarity Determinants in Dendritic Spine Development and Plasticity. Neural Plast (2015) 0.75
The role of 26S proteasome-dependent proteolysis in the formation and restructuring of microtubule networks. Plant Signal Behav (2012) 0.75
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Sci Rep (2016) 0.75
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease. Cell Mol Life Sci (2017) 0.75
Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders. Int J Mol Sci (2017) 0.75
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75
Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies. J Neurosci (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (2002) 3.48
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet (2009) 2.69
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci (2010) 2.66
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci (2007) 1.82
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem (2005) 1.79
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci (2008) 1.78
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell (2002) 1.76
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J (2003) 1.75
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem (2004) 1.62
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci (2011) 1.57
Tau protein and tau aggregation inhibitors. Neuropharmacology (2010) 1.48
Neuronal activity regulates extracellular tau in vivo. J Exp Med (2014) 1.48
Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci (2007) 1.47
Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim Biophys Acta (2004) 1.47
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem (2007) 1.37
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J Biol Chem (2008) 1.34
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J (2011) 1.32
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest (2009) 1.32
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J (2013) 1.31
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry (2008) 1.31
Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging (2011) 1.26
Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathol (2007) 1.26
Surface-decoration of microtubules by human tau. J Mol Biol (2004) 1.21
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure (2006) 1.19
Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Mol Biol Cell (2008) 1.19
Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. J Biol Chem (2008) 1.18
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res (2007) 1.16
The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis. Biochemistry (2006) 1.16
Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration. J Neurosci (2008) 1.16
Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl (2009) 1.13
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (2006) 1.12
PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell (2005) 1.12
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angew Chem Int Ed Engl (2007) 1.11
Kinesin motors and disease. Trends Cell Biol (2002) 1.09
Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry (2007) 1.07
Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem (2013) 1.07
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment. Neurobiol Aging (2010) 1.05
Proteolytic processing of tau. Biochem Soc Trans (2010) 1.04
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Hum Mol Genet (2012) 1.03
Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem (2010) 1.02
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC Neurosci (2008) 1.00
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. J Biol Chem (2006) 1.00
Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex. J Neurosci (2008) 0.98
Screening for inhibitors of tau polymerization. Curr Alzheimer Res (2005) 0.98
Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis. J Biol Chem (2002) 0.97
'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy. Neurodegener Dis (2010) 0.97
Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton. Neurodegener Dis (2011) 0.96
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem (2012) 0.95
Tau's role in the developing brain: implications for intellectual disability. Hum Mol Genet (2011) 0.94
Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model. J Mol Neurosci (2011) 0.94
Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation. Autophagy (2010) 0.93
Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. FEBS J (2013) 0.92
Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. J Biol Chem (2004) 0.89
Making the brain glow: in vivo bioluminescence imaging to study neurodegeneration. Mol Neurobiol (2012) 0.88
Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2010) 0.88
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation. Acta Neuropathol Commun (2015) 0.86
N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands. J Alzheimers Dis (2011) 0.83
Inhibition of tau aggregation in cell models of tauopathy. Curr Alzheimer Res (2007) 0.82
Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. Cell Motil Cytoskeleton (2009) 0.82
X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity. Biochemistry (2008) 0.80
Quantification of amyloid precursor protein and tau for the study of axonal traffic pathways. J Neurosci (2007) 0.78
Conformations of microtubule-associated protein Tau mapped by fluorescence resonance energy transfer. Methods Mol Biol (2012) 0.77
Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity. Brain Res Mol Brain Res (2005) 0.77
Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Struct Funct (2014) 0.77