Published in Hum Mol Genet on February 16, 2010
Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron (2012) 1.58
Nuclear tau, a key player in neuronal DNA protection. J Biol Chem (2010) 1.47
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. Biochim Biophys Acta (2011) 1.16
Protein phosphorylation in neurodegeneration: friend or foe? Front Mol Neurosci (2014) 1.15
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet (2010) 1.01
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet (2012) 0.99
Drosophila melanogaster as a model organism for Alzheimer's disease. Mol Neurodegener (2013) 0.95
Implicating calpain in tau-mediated toxicity in vivo. PLoS One (2011) 0.91
Drosophila models of tauopathies: what have we learned? Int J Alzheimers Dis (2012) 0.85
Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models. Evid Based Complement Alternat Med (2014) 0.81
The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease. Oxid Med Cell Longev (2015) 0.77
Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. J Proteome Res (2013) 0.77
Loss of Polo ameliorates APP-induced Alzheimer's disease-like symptoms in Drosophila. Sci Rep (2015) 0.76
Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau. Biol Open (2017) 0.76
Early glycogen synthase kinase-3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway. Eur J Neurosci (2016) 0.75
Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep (2017) 0.75
The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses. Mol Biol Cell (2015) 0.75
InterPro: the integrative protein signature database. Nucleic Acids Res (2008) 25.07
PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13
Neurodegenerative tauopathies. Annu Rev Neurosci (2001) 9.53
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci (2007) 7.96
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature (2001) 6.76
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A (1986) 6.56
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) Proc Natl Acad Sci U S A (1986) 4.26
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science (2001) 4.25
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (2002) 3.48
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
The endless tale of non-homologous end-joining. Cell Res (2008) 3.03
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol (2006) 2.93
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron (1993) 2.84
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell (2004) 2.78
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol Cell Biol (2004) 2.75
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med (1996) 2.46
Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology (2005) 2.33
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron (2002) 2.28
CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat Rev Cancer (2007) 2.21
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat Rev Drug Discov (2009) 2.08
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem (2002) 2.06
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol Dis (2006) 2.04
Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell (2003) 2.03
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem (2005) 1.88
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem (2006) 1.85
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci (2007) 1.82
Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport (1994) 1.81
Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci (2005) 1.80
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol Psychiatry (2004) 1.79
Genetic modifiers of tauopathy in Drosophila. Genetics (2003) 1.70
The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci (2009) 1.69
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. J Biol Chem (2002) 1.62
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res (2007) 1.62
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem (2004) 1.58
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem (2000) 1.52
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys (1998) 1.51
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol (2004) 1.49
Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol (1995) 1.49
Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Ann Neurol (2005) 1.49
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS One (2008) 1.46
Nucleic acid oxidation in Alzheimer disease. Free Radic Biol Med (2008) 1.45
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol (1995) 1.40
Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest (2006) 1.40
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell (2007) 1.37
Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol (2007) 1.30
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci (2008) 1.28
Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro. J Biol Chem (2004) 1.27
Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Lett (2001) 1.24
Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons. Learn Mem (2004) 1.24
Transgenic animal models of tauopathies. Biochim Biophys Acta (2005) 1.22
Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1. J Neurosci (2007) 1.21
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. Proc Natl Acad Sci U S A (2002) 1.20
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res (2007) 1.16
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med (2008) 1.10
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet (2008) 1.09
Determination of substrate specificity and putative substrates of Chk2 kinase. Biochem Biophys Res Commun (2003) 1.07
Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol (1998) 1.07
Is DNA repair compromised in Alzheimer's disease? Neurobiol Aging (2003) 1.07
Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging (2005) 1.05
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J (2007) 1.04
Animal models reveal role for tau phosphorylation in human disease. Biochim Biophys Acta (2009) 1.01
DNA strand breaks in Alzheimer's disease. Brain Res (1999) 1.01
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol Dis (2005) 0.99
DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. J Neuropathol Exp Neurol (1997) 0.97
The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response. Cell Div (2007) 0.94
Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Brain Res Mol Brain Res (2004) 0.94
Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc Natl Acad Sci U S A (1996) 0.89
Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase. J Neurochem (2005) 0.88
Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87
Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. Mol Cell Neurosci (2003) 0.86
Hypersensitivity to DNA-damaging agents in abiotrophies: a new explanation for degeneration of neurons, photoreceptors, and muscle in Alzheimer, Parkinson and Huntington diseases, retinitis pigmentosa, and Duchenne muscular dystrophy. Basic Life Sci (1985) 0.85
Neurons in the cerebral cortex are most susceptible to DNA-damage in aging rat brain. Biochem Mol Biol Int (1996) 0.84
Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones. Neuroreport (1997) 0.81
Increased steady state mRNA levels of DNA-repair genes XRCC1, ERCC2 and ERCC3 in brain of patients with Down syndrome. Life Sci (1999) 0.79
Alzheimer's disease fibroblasts have normal repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique. Biochem Biophys Res Commun (1987) 0.79
O6-methylguanine-DNA methyltransferase in lymphocytes of the elderly with and without Alzheimer's disease. Mutat Res (1990) 0.76
Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS One (2008) 1.46
JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem (2009) 1.21
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS One (2006) 1.14
Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. PLoS One (2009) 1.05
A Cenozoic record of the equatorial Pacific carbonate compensation depth. Nature (2012) 1.04
Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion. J Biochem (2005) 1.02
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet (2010) 1.01
Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct Funct (2009) 0.96
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila. Proc Natl Acad Sci U S A (2005) 0.95
Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS One (2009) 0.93
Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions. FASEB J (2009) 0.92
Investigating the role for IL-21 in rabies virus vaccine-induced immunity. PLoS Negl Trop Dis (2013) 0.90
Protective vaccine-induced CD4(+) T cell-independent B cell responses against rabies infection. J Virol (2012) 0.89
Comparison of Heterologous Prime-Boost Strategies against Human Immunodeficiency Virus Type 1 Gag Using Negative Stranded RNA Viruses. PLoS One (2013) 0.79