Published in J Biol Chem on June 27, 2006
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC Neurosci (2008) 1.00
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proc Natl Acad Sci U S A (2007) 0.94
The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS Comput Biol (2008) 0.93
Alterations at dispersed sites cause phosphorylation and activation of SNF1 protein kinase during growth on high glucose. J Biol Chem (2011) 0.85
Structural basis for the regulation of maternal embryonic leucine zipper kinase. PLoS One (2013) 0.84
The role of PAS kinase in PASsing the glucose signal. Sensors (Basel) (2010) 0.81
The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity. Bioorg Med Chem Lett (2010) 0.78
Protein kinase A rescues microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating serine 409. J Biol Chem (2014) 0.77
The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity. Acta Crystallogr D Biol Crystallogr (2014) 0.76
Structural insight into the mechanism of synergistic autoinhibition of SAD kinases. Nat Commun (2015) 0.76
Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. Biochem J (2016) 0.75
The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase. Sci Rep (2015) 0.75
Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation. Mol Biol Res Commun (2014) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Global rigid body modeling of macromolecular complexes against small-angle scattering data. Biophys J (2005) 7.10
Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc (2007) 6.53
Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q Rev Biophys (2003) 4.54
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (2002) 3.48
Structural characterization of proteins and complexes using small-angle X-ray solution scattering. J Struct Biol (2010) 3.44
Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins A list of abbreviations can be found in Section 7. Angew Chem Int Ed Engl (2001) 3.44
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet (2009) 2.69
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci (2010) 2.66
Analysis of X-ray and neutron scattering from biomacromolecular solutions. Curr Opin Struct Biol (2007) 2.50
Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med (2012) 2.39
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09
Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution. Acta Crystallogr D Biol Crystallogr (2012) 2.04
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS). Curr Opin Struct Biol (2013) 1.90
Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A (2006) 1.85
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci (2007) 1.82
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem (2005) 1.79
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci (2008) 1.78
Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol (2008) 1.78
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell (2002) 1.76
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J (2003) 1.75
X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure (2008) 1.75
The structure and binding behavior of the bacterial cell surface layer protein SbsC. Structure (2008) 1.72
Structural insights into the molecular organization of the S-layer from Clostridium difficile. Mol Microbiol (2009) 1.71
The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci (2009) 1.69
Global hairpin folding of tau in solution. Biochemistry (2006) 1.69
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Structural basis of dcp2 recognition and activation by dcp1. Mol Cell (2008) 1.65
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem (2004) 1.62
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure (2009) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci (2011) 1.57
Structural insights into eRF3 and stop codon recognition by eRF1. Genes Dev (2009) 1.57
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering. Mol Biosyst (2011) 1.56
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56
Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. Nat Commun (2010) 1.56
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
Addition of missing loops and domains to protein models by x-ray solution scattering. Biophys J (2002) 1.54
The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. Mol Cell (2005) 1.53
Absence of equilibrium cluster phase in concentrated lysozyme solutions. Proc Natl Acad Sci U S A (2008) 1.50
"Lest we forget you--methylene blue...". Neurobiol Aging (2011) 1.50
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49
Tau protein and tau aggregation inhibitors. Neuropharmacology (2010) 1.48
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J (2002) 1.48
Neuronal activity regulates extracellular tau in vivo. J Exp Med (2014) 1.48
Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci (2007) 1.47
GFP-FABD2 fusion construct allows in vivo visualization of the dynamic actin cytoskeleton in all cells of Arabidopsis seedlings. Eur J Cell Biol (2005) 1.47
Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim Biophys Acta (2004) 1.47
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol (2011) 1.46
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42
Conformational space of flexible biological macromolecules from average data. J Am Chem Soc (2010) 1.39
Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB. Structure (2013) 1.39
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem (2007) 1.37
Vesicular trafficking, cytoskeleton and signalling in root hairs and pollen tubes. Trends Plant Sci (2006) 1.37
Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution. Annu Rev Phys Chem (2012) 1.36
Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure (2004) 1.35
Modulation of kinesin binding by the C-termini of tubulin. EMBO J (2004) 1.35
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J Biol Chem (2008) 1.34
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J (2011) 1.32
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? ChemMedChem (2008) 1.32
Nucleotide-induced conformations in the neck region of dimeric kinesin. EMBO J (2003) 1.32
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest (2009) 1.32
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J (2013) 1.31
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry (2008) 1.31
Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin. J Biol Chem (2009) 1.31
Conformation of polypyrimidine tract binding protein in solution. Structure (2006) 1.30
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation. Proc Natl Acad Sci U S A (2011) 1.29
A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly. Structure (2008) 1.28
X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB. J Mol Biol (2008) 1.27