A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMID 26276633)

Published in Cell on August 13, 2015

Authors

Matthieu Flourakis1, Elzbieta Kula-Eversole1, Alan L Hutchison2, Tae Hee Han1, Kimberly Aranda3, Devon L Moose4, Kevin P White5, Aaron R Dinner2, Bridget C Lear4, Dejian Ren3, Casey O Diekman6, Indira M Raman1, Ravi Allada7

Author Affiliations

1: Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
2: Medical Scientist Training Program, James Franck Institute, Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
3: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
4: Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
5: Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
6: Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102, USA.
7: Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA. Electronic address: r-allada@northwestern.edu.

Articles citing this

Circadian rhythms in neuronal activity propagate through output circuits. Nat Neurosci (2016) 1.48

Synchronous Drosophila circadian pacemakers display nonsynchronous Ca²⁺ rhythms in vivo. Science (2016) 0.90

Circadian neuron feedback controls the Drosophila sleep--activity profile. Nature (2016) 0.88

Circuit-based interrogation of sleep control. Nature (2016) 0.88

Biallelic Mutations in UNC80 Cause Persistent Hypotonia, Encephalopathy, Growth Retardation, and Severe Intellectual Disability. Am J Hum Genet (2015) 0.84

Forward-genetics analysis of sleep in randomly mutagenized mice. Nature (2016) 0.83

BK channel inactivation gates daytime excitability in the circadian clock. Nat Commun (2016) 0.78

Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity. Front Psychiatry (2016) 0.78

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife (2016) 0.78

Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock. Sci Rep (2017) 0.77

Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. J Neurosci (2016) 0.77

Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability. Nat Commun (2016) 0.77

NALCN channelopathies: Distinguishing gain-of-function and loss-of-function mutations. Neurology (2016) 0.76

Novel NALCN variant: altered respiratory and circadian rhythm, anesthetic sensitivity. Ann Clin Transl Neurol (2016) 0.76

CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A (2017) 0.75

Circadian Rhythms and Sleep in Drosophila melanogaster. Genetics (2017) 0.75

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Front Cell Neurosci (2017) 0.75

Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila. Sci Rep (2017) 0.75

Physiological responses to daily light exposure. Sci Rep (2016) 0.75

Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability. Proc Natl Acad Sci U S A (2016) 0.75

Neural Circuitry of Wakefulness and Sleep. Neuron (2017) 0.75

Neuroscience: Sleepy and dreamless mutant mice. Nature (2016) 0.75

A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs. Neuron (2017) 0.75

Articles cited by this

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12

Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol (2011) 10.63

JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms (2010) 3.42

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11

The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell (2007) 2.54

Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron (2001) 2.45

Drosophila free-running rhythms require intercellular communication. PLoS Biol (2003) 2.42

Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36

CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science (2011) 2.26

The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron (1998) 2.20

Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J Neurosci (2002) 2.16

A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis (2001) 2.08

Molecular genetic analysis of circadian timekeeping in Drosophila. Adv Genet (2011) 2.04

BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci (2006) 2.01

Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol (2007) 1.94

Linking neural activity and molecular oscillations in the SCN. Nat Rev Neurosci (2011) 1.92

Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock. Nature (2002) 1.76

Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. J Neurosci (2000) 1.72

Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Curr Biol (2007) 1.70

Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila. Curr Biol (2014) 1.61

Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc Natl Acad Sci U S A (2010) 1.58

Circadian rhythm in membrane conductance expressed in isolated neurons. Science (1993) 1.55

Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons. J Neurosci (2008) 1.53

Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. J Neurosci (2004) 1.50

Neurobiology of the fruit fly's circadian clock. Genes Brain Behav (2005) 1.50

Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. Genes Dev (2011) 1.49

Fast delayed rectifier potassium current is required for circadian neural activity. Nat Neurosci (2005) 1.48

Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior. Curr Biol (2010) 1.47

DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila. Curr Biol (2010) 1.47

Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat Neurosci (2009) 1.43

An unusual cation channel mediates photic control of locomotion in Drosophila. Curr Biol (2002) 1.37

Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators. Trends Neurosci (2011) 1.36

The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep (2009) 1.34

Rhythmic regulation of membrane potential and potassium current persists in SCN neurons in the absence of environmental input. Eur J Neurosci (2004) 1.34

The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker. Neuron (2005) 1.30

Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells of Drosophila cause abnormal behavioral rhythms. J Neurobiol (2000) 1.21

The Drosophila circadian clock is a variably coupled network of multiple peptidergic units. Science (2014) 1.21

Daily rhythmicity of large-conductance Ca2+ -activated K+ currents in suprachiasmatic nucleus neurons. Brain Res (2006) 1.20

Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus. J Neurosci (2005) 1.09

Electrophysiological and anatomical characterization of PDF-positive clock neurons in the intact adult Drosophila brain. J Neurophysiol (2006) 1.08

Encoding the ins and outs of circadian pacemaking. J Biol Rhythms (2006) 1.08

Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus. Neuroreport (1998) 1.08

Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior. PLoS Biol (2014) 1.07

Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell (2014) 1.06

PDF neuron firing phase-shifts key circadian activity neurons in Drosophila. Elife (2014) 1.06

Modeling the electrophysiology of suprachiasmatic nucleus neurons. J Biol Rhythms (2007) 1.01

Fast delayed rectifier potassium current: critical for input and output of the circadian system. J Neurosci (2011) 1.00

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet (2013) 0.96

CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A (2015) 0.95

Electrophysiology of the circadian pacemaker in mammals. Chronobiol Int (2003) 0.93

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant. Elife (2014) 0.92

Causes and consequences of hyperexcitation in central clock neurons. PLoS Comput Biol (2013) 0.92

NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. Neuron (2013) 0.90

UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. PLoS One (2013) 0.88

Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data. PLoS Comput Biol (2015) 0.85

Clustering predicted by an electrophysiological model of the suprachiasmatic nucleus. J Biol Rhythms (2009) 0.85

A delayed rectifier current is modulated by the circadian pacemaker in Bulla. J Biol Rhythms (1999) 0.83

Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Front Mol Neurosci (2014) 0.79

Models of electrical activity: calibration and prediction testing on the same cell. Biophys J (2012) 0.78

Patch-clamp electrophysiology in Drosophila circadian pacemaker neurons. Methods Enzymol (2014) 0.77