Published in Annu Rev Cell Dev Biol on January 01, 2009
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell (2010) 3.41
Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat Rev Nephrol (2013) 2.66
Building muscle: molecular regulation of myogenesis. Cold Spring Harb Perspect Biol (2012) 2.52
Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol (2014) 2.36
Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell (2011) 2.31
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13
Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nat Cell Biol (2012) 1.89
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol (2010) 1.71
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell (2011) 1.71
Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell (2011) 1.65
Tracking adult stem cells. EMBO Rep (2011) 1.56
Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation. Blood (2015) 1.55
Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression. Urol Oncol (2010) 1.49
Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. PLoS Genet (2014) 1.44
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nat Immunol (2014) 1.43
Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle (2012) 1.42
Neurogenesis at the brain-cerebrospinal fluid interface. Annu Rev Cell Dev Biol (2011) 1.42
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Stem cells and cancer of the stomach and intestine. Mol Oncol (2010) 1.37
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32
Imaging hallmarks of cancer in living mice. Nat Rev Cancer (2014) 1.32
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31
A matter of life and death: self-renewal in stem cells. EMBO Rep (2012) 1.30
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS One (2010) 1.30
Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science (2016) 1.25
Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell (2014) 1.21
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci (2011) 1.20
Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state. Stem Cells Dev (2012) 1.18
Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood (2013) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population. J Biol Chem (2012) 1.13
Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS One (2011) 1.11
MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol (2013) 1.11
Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis. Exp Cell Res (2014) 1.11
Caenorhabditis elegans as a model for stem cell biology. Dev Dyn (2010) 1.11
The abbreviated pluripotent cell cycle. J Cell Physiol (2013) 1.09
Ink4-Arf locus in cancer and aging. Wiley Interdiscip Rev Dev Biol (2013) 1.09
Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models. Results Probl Cell Differ (2012) 1.03
Embryonic anti-aging niche. Aging (Albany NY) (2011) 1.02
Renal stem cells: fact or science fiction? Biochem J (2012) 1.02
FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports (2014) 1.02
EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. Int J Mol Sci (2013) 1.02
Somatic cell lineage is required for differentiation and not maintenance of germline stem cells in Drosophila testes. Proc Natl Acad Sci U S A (2012) 1.00
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation. Development (2013) 0.99
Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features. Front Oncol (2013) 0.99
Metabolic regulation of stem cell function. J Intern Med (2014) 0.97
Cellular differences in protein synthesis regulate tissue homeostasis. Cell (2014) 0.97
The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev (2013) 0.97
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood (2012) 0.96
A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells. Cell Rep (2015) 0.94
Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol (2013) 0.92
Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Nat Commun (2012) 0.91
Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J (2015) 0.91
5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation. PLoS One (2014) 0.91
Transcriptomic portrait of human Mesenchymal Stromal/Stem Cells isolated from bone marrow and placenta. BMC Genomics (2014) 0.90
Lung cancer stem cells: progress and prospects. Cancer Lett (2012) 0.90
Review: corneal epithelial stem cells, their niche and wound healing. Mol Vis (2013) 0.90
Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS One (2011) 0.90
Stem cells, redox signaling, and stem cell aging. Antioxid Redox Signal (2014) 0.89
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Mol Cell Biol (2011) 0.88
Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation. PLoS One (2011) 0.88
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. Blood (2012) 0.87
Effects of Na/K-ATPase and its ligands on bone marrow stromal cell differentiation. Stem Cell Res (2014) 0.87
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development (2015) 0.87
Stem cell therapy: an exercise in patience and prudence. Philos Trans R Soc Lond B Biol Sci (2013) 0.86
Hmga2 regulates self-renewal of retinal progenitors. Development (2014) 0.86
A model of stem cell population dynamics: in silico analysis and in vivo validation. Development (2012) 0.86
Can nanomedicines kill cancer stem cells? Adv Drug Deliv Rev (2013) 0.86
DNA Damage Response in Hematopoietic Stem Cell Ageing. Genomics Proteomics Bioinformatics (2016) 0.85
HiJAK'd Signaling; the STAT3 Paradox in Senescence and Cancer Progression. Cancers (Basel) (2014) 0.85
Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci (2011) 0.84
Effects of inflammation on stem cells: together they strive? EMBO Rep (2015) 0.84
Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages. Biochim Biophys Acta (2014) 0.83
Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood (2014) 0.82
Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells. PLoS One (2012) 0.82
The ERGonomics of hematopoietic stem cell self-renewal. Genes Dev (2011) 0.82
PIWI homologs mediate histone H4 mRNA localization to planarian chromatoid bodies. Development (2014) 0.82
Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells Dev (2012) 0.82
Characterizing the dielectric properties of human mesenchymal stem cells and the effects of charged elastin-like polypeptide copolymer treatment. Biomicrofluidics (2014) 0.81
Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways. Mol Cancer Res (2012) 0.81
Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia? Curr Oncol (2016) 0.81
Stem cell niche dynamics: from homeostasis to carcinogenesis. Stem Cells Int (2012) 0.81
Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations. Elife (2016) 0.80
Extrafollicular dermal melanocyte stem cells and melanoma. Stem Cells Int (2012) 0.80
Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development (2013) 0.80
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells. Cell Cycle (2015) 0.80
Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention. Mol Cancer (2017) 0.80
Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks. Stem Cells (2014) 0.80
p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood (2016) 0.79
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges. Int J Mol Sci (2015) 0.79
Cytoarchitecture and ultrastructure of neural stem cell niches and neurogenic complexes maintaining adult neurogenesis in the olfactory midbrain of spiny lobsters, Panulirus argus. J Comp Neurol (2011) 0.79
Characterization of adipose-derived stem cells of anatomical region from mice. BMC Res Notes (2014) 0.79
Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition. Cell Death Dis (2015) 0.79
Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells. J Gastroenterol (2014) 0.78
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature (2006) 8.06
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
Tumour heterogeneity and cancer cell plasticity. Nature (2013) 5.47
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell (2008) 5.07
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol (2008) 4.42
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron (2002) 3.92
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol (2004) 3.34
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood (2005) 3.22
Hirschsprung disease is linked to defects in neural crest stem cell function. Science (2003) 2.98
Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell (2007) 2.96
Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron (2002) 2.85
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest (2011) 1.88
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell (2010) 1.82
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Maintaining hematopoietic stem cells in the vascular niche. Immunity (2006) 1.72
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol (2010) 1.71
CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood (2005) 1.64
CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood (2008) 1.45
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Neuron (2003) 1.41
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell (2009) 1.39
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev (2011) 1.36
Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell (2009) 1.36
Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell (2005) 1.35
Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC. Genes Cells (2002) 1.30
Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism. Mol Cell Biol (2004) 1.28
Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol (2005) 1.22
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (2010) 1.17
Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med (2009) 1.17
An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood (2010) 1.11
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol (2009) 1.10
Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev Biol (2002) 1.03
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01
Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol (2006) 1.00
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. PLoS One (2012) 0.98
Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell (2012) 0.97
Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers. Blood (2010) 0.96
Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest (2012) 0.96
Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci (2010) 0.91
The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis (2008) 0.89
Brain repair by endogenous progenitors. Cell (2002) 0.86
Stem-cell competition. Nature (2002) 0.84
Pten-uating neural growth. Nat Med (2002) 0.77
Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun (2016) 0.77
Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature (2016) 0.75
Crossing the boundaries of sensory neurogenesis. Nat Neurosci (2004) 0.75