Published in Science on August 15, 2003
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature (2009) 7.04
Molecular analysis of neural crest migration. Philos Trans R Soc Lond B Biol Sci (2008) 1.56
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Characterisation and transplantation of enteric nervous system progenitor cells. Gut (2006) 1.53
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood (2008) 1.45
A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol (2004) 1.44
s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue. Genes Dev (2010) 1.39
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Philos Trans R Soc Lond B Biol Sci (2008) 1.33
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A (2006) 1.30
Genetic basis of Hirschsprung's disease. Pediatr Surg Int (2009) 1.25
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19
Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease. Neurogastroenterol Motil (2009) 1.07
Genetic background impacts developmental potential of enteric neural crest-derived progenitors in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet (2010) 1.06
Isolation and live imaging of enteric progenitors based on Sox10-Histone2BVenus transgene expression. Genesis (2011) 1.02
Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer (2013) 1.00
Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol (2006) 1.00
Discovery of transcription factors and other candidate regulators of neural crest development. Dev Dyn (2008) 1.00
Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol (2012) 0.99
A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes Dev (2007) 0.98
The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. J Neurosci (2010) 0.98
Novel classification and pathogenetic analysis of hypoganglionosis and adult-onset Hirschsprung's disease. Dig Dis Sci (2011) 0.95
The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease. Am J Pathol (2006) 0.94
Transplanting the enteric nervous system: a step closer to treatment for aganglionosis. Gut (2007) 0.92
Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci (2010) 0.91
Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on ret proto-oncogene activity. J Clin Endocrinol Metab (2009) 0.90
Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences. Fibrogenesis Tissue Repair (2013) 0.87
HOXB5 cooperates with NKX2-1 in the transcription of human RET. PLoS One (2011) 0.87
The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut. J Neurogastroenterol Motil (2013) 0.87
Genetic variants in RET and risk of Hirschsprung's disease in Southeastern Chinese: a haplotype-based analysis. BMC Med Genet (2011) 0.87
A stable cranial neural crest cell line from mouse. Stem Cells Dev (2012) 0.87
Origins of gliogenic stem cell populations within adult skin and bone marrow. Stem Cells Dev (2010) 0.86
Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells. Mol Vis (2010) 0.86
Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population. Gut (2007) 0.85
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci (2012) 0.84
Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS One (2011) 0.84
The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth. Int J Colorectal Dis (2012) 0.84
Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease. Neurogastroenterol Motil (2015) 0.84
The genetic and molecular bases of monogenic disorders affecting proteolytic systems. J Med Genet (2005) 0.83
Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders. Neuropharmacology (2011) 0.81
Smooth muscle proteins from Hirschsprung's disease facilitates stem cell differentiation. Pediatr Surg Int (2012) 0.81
A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep. Am J Hum Genet (2004) 0.80
Effects of RET, NRG1 and NRG3 Polymorphisms in a Chinese Population with Hirschsprung Disease. Sci Rep (2017) 0.78
Transplantation of mesenchymal stem cells into the renal medulla attenuated salt-sensitive hypertension in Dahl S rat. J Mol Med (Berl) (2014) 0.78
Class 3 semaphorins negatively regulate dermal lymphatic network formation. Biol Open (2015) 0.78
Differential expression of FOXA1, DUSP6, and HA117 in colon segments of Hirschsprung's disease. Int J Clin Exp Pathol (2015) 0.78
Stem cell defects as a possible cause of Hirschsprung's disease. Gastroenterology (2004) 0.75
Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application. Stem Cells Int (2016) 0.75
Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors. FEBS Lett (2017) 0.75
Fatal Toxic Megacolon in a Child of Hirschsprung Disease. J Clin Diagn Res (2016) 0.75
Thyroid C-Cell Biology and Oncogenic Transformation. Recent Results Cancer Res (2015) 0.75
Detection and preliminary screening of the human gene expression profile for Hirschsprung's disease. Mol Med Rep (2015) 0.75
Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci Rep (2016) 0.75
[Genetic bases of Hirschsprung's disease]. Pathologe (2007) 0.75
"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55
A stem cell molecular signature. Science (2002) 14.47
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature (1994) 5.61
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science (2000) 4.65
Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell (1999) 4.54
Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature (1996) 4.37
Renal and neuronal abnormalities in mice lacking GDNF. Nature (1996) 4.06
Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med (2002) 3.94
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron (2002) 3.92
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science (2000) 3.63
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet (1996) 3.42
Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell (1996) 3.39
Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature (1994) 3.33
Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A (2000) 3.12
Segregation at three loci explains familial and population risk in Hirschsprung disease. Nat Genet (2002) 3.07
SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron (2003) 2.98
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91
Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J Neurosci (2000) 2.86
The genetic program of hematopoietic stem cells. Science (2000) 2.85
Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron (2002) 2.85
A genetic analysis of neural progenitor differentiation. Neuron (2001) 2.66
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66
GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron (1998) 2.34
GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron (1998) 2.29
Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc Natl Acad Sci U S A (2002) 2.04
Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development (2002) 1.92
Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development (1996) 1.75
GDNF is a chemoattractant for enteric neural cells. Dev Biol (2001) 1.73
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
Enteric nervous system: development and developmental disturbances--part 1. Pediatr Dev Pathol (2002) 1.56
Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Dev Biol (1998) 1.55
Stem cells and pattern formation in the nervous system: the possible versus the actual. Neuron (2001) 1.47
Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development (1999) 1.46
Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities. Neuron (1995) 1.20
Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease. Hum Mol Genet (2002) 0.83
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature (2006) 8.06
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
Tumour heterogeneity and cancer cell plasticity. Nature (2013) 5.47
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell (2008) 5.07
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol (2008) 4.42
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron (2002) 3.92
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol (2004) 3.34
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood (2005) 3.22
Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol (2009) 3.00
Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell (2007) 2.96
Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron (2002) 2.85
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest (2011) 1.88
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell (2010) 1.82
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Maintaining hematopoietic stem cells in the vascular niche. Immunity (2006) 1.72
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol (2010) 1.71
CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood (2005) 1.64
CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47
Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease. Neurosurgery (2003) 1.47
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood (2008) 1.45
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Neuron (2003) 1.41
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell (2009) 1.39
Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell (2009) 1.36
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev (2011) 1.36
Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell (2005) 1.35
Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol (2005) 1.22
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells. J Physiol (2003) 1.21
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proc Natl Acad Sci U S A (2007) 1.17
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (2010) 1.17
Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med (2009) 1.17
An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood (2010) 1.11
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol (2009) 1.10
Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev Biol (2002) 1.03
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01
Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol (2006) 1.00
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell (2012) 0.97
Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest (2012) 0.96
Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers. Blood (2010) 0.96
Cellular properties and chemosensory responses of the human carotid body. J Physiol (2013) 0.94
Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci (2010) 0.91
Distinct roles for SCL in erythroid specification and maturation in zebrafish. J Biol Chem (2005) 0.90
Oxygen sensing in the carotid body. Ann N Y Acad Sci (2009) 0.89
The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis (2008) 0.89
Brain repair by endogenous progenitors. Cell (2002) 0.86
Stem-cell competition. Nature (2002) 0.84
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats. J Neurosci (2003) 0.83
Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease. Brain Res Bull (2002) 0.79
The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy. J Neural Transm (Vienna) (2009) 0.78
Studies on glomus cell sensitivity to hypoxia in carotid body slices. Adv Exp Med Biol (2003) 0.77
Pten-uating neural growth. Nat Med (2002) 0.77
Glucose sensing cells in the carotid body. Adv Exp Med Biol (2003) 0.77
Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun (2016) 0.77
Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature (2016) 0.75
Crossing the boundaries of sensory neurogenesis. Nat Neurosci (2004) 0.75
Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body. Adv Exp Med Biol (2015) 0.75