Published in Curr Opin Cell Biol on December 01, 2004
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc Natl Acad Sci U S A (2005) 2.77
Cell lineages and the logic of proliferative control. PLoS Biol (2009) 2.62
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos Trans R Soc Lond B Biol Sci (2008) 1.91
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet (2009) 1.86
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol (2006) 1.86
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. Blood (2012) 1.83
Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures. Mol Biol Cell (2008) 1.75
Stability and dynamics of polycomb target sites in Drosophila development. PLoS Genet (2008) 1.72
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev (2010) 1.66
Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65
Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res (2010) 1.58
Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle (2009) 1.56
BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res (2008) 1.56
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54
Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest (2008) 1.53
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Long-term self-renewal of postnatal muscle-derived stem cells. Mol Biol Cell (2005) 1.42
The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci (2009) 1.30
p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun (2010) 1.25
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53. Cell Death Dis (2010) 1.20
Aging of signal transduction pathways, and pathology. Exp Cell Res (2008) 1.16
Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proc Natl Acad Sci U S A (2013) 1.13
Malignant melanoma in the 21st century: the emerging molecular landscape. Mayo Clin Proc (2008) 1.13
Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach. J Exp Clin Cancer Res (2013) 1.13
Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia (2010) 1.11
Caenorhabditis elegans as a model for stem cell biology. Dev Dyn (2010) 1.11
Laminin enhances the growth of human neural stem cells in defined culture media. BMC Neurosci (2008) 1.10
Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol (2008) 1.08
p73: a multifunctional protein in neurobiology. Mol Neurobiol (2011) 1.07
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci (2010) 1.06
Are cancer stem cells radioresistant? Future Oncol (2010) 1.01
Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain (2009) 0.97
Inhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells. PLoS One (2011) 0.94
MicroRNAs as novel regulators of stem cell fate. World J Stem Cells (2013) 0.94
Cancer stem cells: repair gone awry? J Oncol (2010) 0.92
Phytochemicals as Innovative Therapeutic Tools against Cancer Stem Cells. Int J Mol Sci (2015) 0.91
Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells. PLoS One (2013) 0.89
Expression of OCT4A: the first step to the next stage of urothelial bladder cancer progression. Int J Mol Sci (2014) 0.89
Molecular control of stem cell maintenance in shoot apical meristem. Plant Cell Rep (2005) 0.87
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood (2011) 0.86
C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. Dev Biol (2009) 0.86
UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch. J Invest Dermatol (2015) 0.85
Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors. Breast Cancer Res Treat (2012) 0.85
Roles of p53 in various biological aspects of hematopoietic stem cells. J Biomed Biotechnol (2012) 0.84
Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation. Radiat Oncol (2007) 0.83
Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks. Virchows Arch (2008) 0.82
Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations. Neuron Glia Biol (2007) 0.82
Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to zones of cell proliferation. Evodevo (2014) 0.82
Regulation of cellular chromatin state: insights from quiescence and differentiation. Organogenesis (2010) 0.82
PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One (2014) 0.81
Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol (2006) 0.81
Distinct transcriptional networks in quiescent myoblasts: a role for Wnt signaling in reversible vs. irreversible arrest. PLoS One (2013) 0.81
Stem cell niche dynamics: from homeostasis to carcinogenesis. Stem Cells Int (2012) 0.81
Epithelial stem cells and malignancy. J Anat (2008) 0.80
Mammary stem cell research in veterinary science: an update. Stem Cells Dev (2013) 0.80
Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling. Mol Brain (2009) 0.79
Asymmetric cell division of stem cells in the lung and other systems. Front Cell Dev Biol (2014) 0.79
Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons. Neurochem Int (2012) 0.79
The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation. Mol Brain (2015) 0.79
Introduction to stem cell therapy. J Cardiovasc Nurs (2009) 0.78
Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival. J Clin Invest (2014) 0.77
Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1. Int J Oncol (2015) 0.77
Update on small intestinal stem cells. World J Gastroenterol (2013) 0.77
Involvement of CD137 ligand signaling in neural stem cell death. Mol Cells (2013) 0.77
Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancer. Reprod Sci (2014) 0.77
Activated Notch1 expression is associated with angiogenesis in cutaneous melanoma. Clin Exp Med (2014) 0.77
A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia (2015) 0.76
Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin? Aging (Albany NY) (2012) 0.76
Evaluation of the 'Hedgehog' signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncol Lett (2016) 0.76
Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. J Biol Chem (2016) 0.75
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75
Oncolytic virus as a cancer stem cell killer: progress and challenges. Stem Cell Investig (2014) 0.75
Obesity and inflammation and the effect on the hematopoietic system. Rev Bras Hematol Hemoter (2014) 0.75
RANK-RANKL signalling in cancer. Biosci Rep (2016) 0.75
RB: An essential player in adult neurogenesis. Neurogenesis (Austin) (2017) 0.75
Overview of Cancer Stem Cells and Stemness for Community Oncologists. Target Oncol (2017) 0.75
RUNX1 Plays an Important Role in Mediating BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Line C3H10T1/2, Murine Multi-Lineage Cells Lines C2C12 and MEFs. Int J Mol Sci (2017) 0.75
Structural and component characterization of meristem cells in Araucaria angustifolia (Bert.) O. Kuntze zygotic embryo. Protoplasma (2012) 0.75
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature (2006) 8.06
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
Tumour heterogeneity and cancer cell plasticity. Nature (2013) 5.47
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell (2008) 5.07
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol (2008) 4.42
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron (2002) 3.92
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood (2005) 3.22
Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol (2009) 3.00
Hirschsprung disease is linked to defects in neural crest stem cell function. Science (2003) 2.98
Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell (2007) 2.96
Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron (2002) 2.85
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest (2011) 1.88
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell (2010) 1.82
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Maintaining hematopoietic stem cells in the vascular niche. Immunity (2006) 1.72
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol (2010) 1.71
CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood (2005) 1.64
CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47
Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease. Neurosurgery (2003) 1.47
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood (2008) 1.45
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Neuron (2003) 1.41
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell (2009) 1.39
Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell (2009) 1.36
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev (2011) 1.36
Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell (2005) 1.35
Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol (2005) 1.22
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells. J Physiol (2003) 1.21
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (2010) 1.17
Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med (2009) 1.17
An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood (2010) 1.11
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol (2009) 1.10
Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev Biol (2002) 1.03
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01
Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol (2006) 1.00
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell (2012) 0.97
Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers. Blood (2010) 0.96
Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest (2012) 0.96
Cellular properties and chemosensory responses of the human carotid body. J Physiol (2013) 0.94
Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci (2010) 0.91
Oxygen sensing in the carotid body. Ann N Y Acad Sci (2009) 0.89
The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis (2008) 0.89
Brain repair by endogenous progenitors. Cell (2002) 0.86
Stem-cell competition. Nature (2002) 0.84
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats. J Neurosci (2003) 0.83
Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease. Brain Res Bull (2002) 0.79
The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy. J Neural Transm (Vienna) (2009) 0.78
Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun (2016) 0.77
Pten-uating neural growth. Nat Med (2002) 0.77
Studies on glomus cell sensitivity to hypoxia in carotid body slices. Adv Exp Med Biol (2003) 0.77
Glucose sensing cells in the carotid body. Adv Exp Med Biol (2003) 0.77
Crossing the boundaries of sensory neurogenesis. Nat Neurosci (2004) 0.75
Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature (2016) 0.75
Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body. Adv Exp Med Biol (2015) 0.75