Published in PLoS One on July 16, 2009
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev (2013) 2.01
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer (2011) 1.58
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. PLoS One (2011) 1.16
Biofilm-specific antibiotic tolerance and resistance. Eur J Clin Microbiol Infect Dis (2015) 1.09
Microcolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation. Mol Microbiol (2012) 1.09
Concentration-dependent activity of antibiotics in natural environments. Front Microbiol (2013) 1.06
Planktonic aggregates of Staphylococcus aureus protect against common antibiotics. PLoS One (2012) 1.02
Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation. Proc Natl Acad Sci U S A (2014) 0.97
Biofilms 2009: new perspectives at the heart of surface-associated microbial communities. J Bacteriol (2010) 0.94
Pseudomonas aeruginosa Biofilm Response and Resistance to Cold Atmospheric Pressure Plasma Is Linked to the Redox-Active Molecule Phenazine. PLoS One (2015) 0.94
Genotypic and phenotypic variation in Pseudomonas aeruginosa reveals signatures of secondary infection and mutator activity in certain cystic fibrosis patients with chronic lung infections. Infect Immun (2011) 0.92
Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment. Antimicrob Agents Chemother (2011) 0.90
Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms. PLoS Pathog (2011) 0.90
Evolution and adaptation in Pseudomonas aeruginosa biofilms driven by mismatch repair system-deficient mutators. PLoS One (2011) 0.87
Experimental evolution in biofilm populations. FEMS Microbiol Rev (2016) 0.84
Interspecific diversity reduces and functionally substitutes for intraspecific variation in biofilm communities. ISME J (2015) 0.80
The mutagenic footprint of low-fidelity Pol I ColE1 plasmid replication in E. coli reveals an extensive interplay between Pol I and Pol III. Curr Genet (2013) 0.80
nfxB as a novel target for analysis of mutation spectra in Pseudomonas aeruginosa. PLoS One (2013) 0.80
Environmental cues and genes involved in establishment of the superinfective Pf4 phage of Pseudomonas aeruginosa. Front Microbiol (2014) 0.80
The Complex Relationship between Virulence and Antibiotic Resistance. Genes (Basel) (2017) 0.79
The evolution of antibiotic susceptibility and resistance during the formation of Escherichia coli biofilms in the absence of antibiotics. BMC Evol Biol (2013) 0.79
Antimicrobial Drugs in Fighting against Antimicrobial Resistance. Front Microbiol (2016) 0.79
Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma. Sci Rep (2016) 0.77
Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model. BMC Microbiol (2017) 0.75
Evolution of Ecological Diversity in Biofilms of Pseudomonas aeruginosa by Altered Cyclic Diguanylate Signaling. J Bacteriol (2016) 0.75
Quorum Sensing of Periodontal Pathogens. Acta Stomatol Croat (2015) 0.75
Real Time, Spatial and Temporal Mapping of the Distribution of c-di-GMP During Biofilm Development. J Biol Chem (2016) 0.75
Involvement of stress-related genes polB and PA14_46880 in biofilm formation of Pseudomonas aeruginosa. Infect Immun (2014) 0.75
Spatial Organization Plasticity as an Adaptive Driver of Surface Microbial Communities. Front Microbiol (2017) 0.75
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature (2000) 32.30
Quantification of biofilm structures by the novel computer program COMSTAT. Microbiology (2000) 11.05
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature (2000) 10.32
Cancer as an evolutionary and ecological process. Nat Rev Cancer (2006) 9.33
High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science (2000) 9.14
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
Evolution of high mutation rates in experimental populations of E. coli. Nature (1997) 8.68
Intracellular bacterial biofilm-like pods in urinary tract infections. Science (2003) 7.10
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature (2002) 7.08
Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol (2002) 6.98
A 10-min method for preparation of highly electrocompetent Pseudomonas aeruginosa cells: application for DNA fragment transfer between chromosomes and plasmid transformation. J Microbiol Methods (2005) 6.02
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants. Mol Microbiol (2003) 5.31
Self-generated diversity produces "insurance effects" in biofilm communities. Proc Natl Acad Sci U S A (2004) 4.54
A mutator phenotype in cancer. Cancer Res (2001) 4.41
Autolysis and autoaggregation in Pseudomonas aeruginosa colony morphology mutants. J Bacteriol (2002) 4.04
Cell death in Pseudomonas aeruginosa biofilm development. J Bacteriol (2003) 3.74
Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11
Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms. Mol Microbiol (2003) 3.05
Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J Bacteriol (2006) 2.97
Biofilms promote altruism. Microbiology (2004) 2.96
Role of alginate and its O acetylation in formation of Pseudomonas aeruginosa microcolonies and biofilms. J Bacteriol (2001) 2.87
In situ gene expression in mixed-culture biofilms: evidence of metabolic interactions between community members. Appl Environ Microbiol (1998) 2.82
Development and dynamics of Pseudomonas sp. biofilms. J Bacteriol (2000) 2.72
Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations. J Mol Evol (2003) 2.47
Characterization of phenotypic changes in Pseudomonas putida in response to surface-associated growth. J Bacteriol (2001) 2.33
The developmental model of microbial biofilms: ten years of a paradigm up for review. Trends Microbiol (2009) 2.23
Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes. Genome Res (2005) 2.22
A panel of Tn7-based vectors for insertion of the gfp marker gene or for delivery of cloned DNA into Gram-negative bacteria at a neutral chromosomal site. J Microbiol Methods (2001) 2.20
Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection. J Med Microbiol (2003) 2.17
Evolution of mutation rates in bacteria. Mol Microbiol (2006) 2.14
Bacteriophage and phenotypic variation in Pseudomonas aeruginosa biofilm development. J Bacteriol (2004) 2.08
Growth and detachment of cell clusters from mature mixed-species biofilms. Appl Environ Microbiol (2001) 2.08
Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob Agents Chemother (2005) 2.08
Phenotypic differentiation and seeding dispersal in non-mucoid and mucoid Pseudomonas aeruginosa biofilms. Microbiology (2005) 2.03
Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach. Biotechnol Bioeng (1998) 2.02
Endogenous oxidative stress produces diversity and adaptability in biofilm communities. Proc Natl Acad Sci U S A (2008) 2.00
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother (2005) 1.94
Genetic and sequence analysis of frameshift mutations induced by ICR-191. J Mol Biol (1981) 1.82
Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infections. Antimicrob Agents Chemother (2004) 1.67
The role of the microcolony mode of growth in the pathogenesis of Pseudomonas aeruginosa infections. Rev Infect Dis (1984) 1.60
Hypermutation as a factor contributing to the acquisition of antimicrobial resistance. Clin Infect Dis (2003) 1.58
Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms. J Bacteriol (2006) 1.46
Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria. J Bacteriol (2008) 1.42
Too many mutants with multiple mutations. Crit Rev Biochem Mol Biol (2007) 1.38
Endogenous DNA damage and mutation. Trends Genet (2001) 1.34
Formation of Streptococcus pneumoniae non-phase-variable colony variants is due to increased mutation frequency present under biofilm growth conditions. J Bacteriol (2008) 1.20
Increased mutability of Pseudomonas aeruginosa in biofilms. J Antimicrob Chemother (2008) 1.20
Horizontal acquisition of divergent chromosomal DNA in bacteria: effects of mutator phenotypes. Genetics (2003) 1.06
Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers. Eur J Immunol (1999) 1.01
A novel bacterial reversion and forward mutation assay based on green fluorescent protein. Mutat Res (1998) 0.93
Measurements of accumulation and displacement at the single cell cluster level in Pseudomonas aeruginosa biofilms. Environ Microbiol (2008) 0.86
Internal hazards: baseline DNA damage by endogenous products of normal metabolism. Mutat Res (1999) 0.85
Mutagenicity of acridines in a reversion assay based on tetracycline resistance in plasmid pBR322 in Escherichia coli. Mutat Res (1996) 0.80
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Mol Microbiol (2006) 4.49
Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J Bacteriol (2006) 2.97
A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol (2007) 2.53
Enhanced biofilm formation and increased resistance to antimicrobial agents and bacterial invasion are caused by synergistic interactions in multispecies biofilms. Appl Environ Microbiol (2006) 2.08
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal. J Bacteriol (2009) 1.78
Competitive interactions in mixed-species biofilms containing the marine bacterium Pseudoalteromonas tunicata. Appl Environ Microbiol (2005) 1.70
The biofilm life cycle and virulence of Pseudomonas aeruginosa are dependent on a filamentous prophage. ISME J (2008) 1.58
Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense. PLoS One (2008) 1.56
Biofilm development and cell death in the marine bacterium Pseudoalteromonas tunicata. Appl Environ Microbiol (2004) 1.55
Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria. J Bacteriol (2008) 1.42
Low densities of epiphytic bacteria from the marine alga Ulva australis inhibit settlement of fouling organisms. Appl Environ Microbiol (2007) 1.41
The alternative sigma factor RpoN regulates the quorum sensing gene rhlI in Pseudomonas aeruginosa. FEMS Microbiol Lett (2003) 1.31
Pseudomonas aeruginosa PAO1 preferentially grows as aggregates in liquid batch cultures and disperses upon starvation. PLoS One (2009) 1.31
Expression of the psl operon in Pseudomonas aeruginosa PAO1 biofilms: PslA performs an essential function in biofilm formation. Appl Environ Microbiol (2005) 1.31
Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms. Microb Biotechnol (2009) 1.26
Microbial colonization and competition on the marine alga Ulva australis. Appl Environ Microbiol (2006) 1.25
Ecological advantages of autolysis during the development and dispersal of Pseudoalteromonas tunicata biofilms. Appl Environ Microbiol (2006) 1.17
Biofilm differentiation and dispersal in mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Microbiology (2007) 1.15
The role of polyhydroxyalkanoate biosynthesis by Pseudomonas aeruginosa in rhamnolipid and alginate production as well as stress tolerance and biofilm formation. Microbiology (2004) 1.11
Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. J Med Microbiol (2008) 1.00
Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation. Proc Natl Acad Sci U S A (2014) 0.97
Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression. J Inflamm (Lond) (2008) 0.96
Can Simpson's paradox explain co-operation in Pseudomonas aeruginosa biofilms? FEMS Immunol Med Microbiol (2012) 0.91
Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. J Inflamm (Lond) (2013) 0.89
A mannose-sensitive haemagglutinin (MSHA)-like pilus promotes attachment of Pseudoalteromonas tunicata cells to the surface of the green alga Ulva australis. Microbiology (2006) 0.88
Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms. Angew Chem Int Ed Engl (2012) 0.86
Risk of red queen dynamics in pneumococcal vaccine strategy. Trends Microbiol (2011) 0.86
Biofilm dispersal cells of a cystic fibrosis Pseudomonas aeruginosa isolate exhibit variability in functional traits likely to contribute to persistent infection. FEMS Immunol Med Microbiol (2012) 0.85
Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. BMC Pulm Med (2014) 0.81
An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. J Am Chem Soc (2014) 0.80
Dynamic modelling of cell death during biofilm development. J Theor Biol (2011) 0.80
Enhanced benzaldehyde tolerance in Zymomonas mobilis biofilms and the potential of biofilm applications in fine-chemical production. Appl Environ Microbiol (2006) 0.80
Ability of Pseudoalteromonas tunicata to colonize natural biofilms and its effect on microbial community structure. FEMS Microbiol Ecol (2010) 0.77
Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids. PLoS One (2011) 0.75
Biofilm prevention of gram-negative bacterial pathogens involved in periprosthetic infection by antibiotic-loaded calcium sulfate beads in vitro. Biomed Mater (2016) 0.75