Too many mutants with multiple mutations.

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell (2012) 4.52

Mutation as a stress response and the regulation of evolvability. Crit Rev Biochem Mol Biol (2007) 3.66

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet (2008) 2.00

Derivation of Escherichia coli O157:H7 from its O55:H7 precursor. PLoS One (2010) 1.90

Is evolution Darwinian or/and Lamarckian? Biol Direct (2009) 1.67

Localized hypermutation and associated gene losses in legume chloroplast genomes. Genome Res (2010) 1.48

Rates and genomic consequences of spontaneous mutational events in Drosophila melanogaster. Genetics (2013) 1.48

Stress alters rates and types of loss of heterozygosity in Candida albicans. MBio (2011) 1.38

The rate of establishment of complex adaptations. Mol Biol Evol (2010) 1.17

Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli. Cell Rep (2012) 1.14

Role of mutation in Pseudomonas aeruginosa biofilm development. PLoS One (2009) 1.11

A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast. DNA Repair (Amst) (2010) 1.03

The relationship between mutation frequency and replication strategy in positive-sense single-stranded RNA viruses. Proc Biol Sci (2009) 0.98

Seeing mutations in living cells. Curr Biol (2010) 0.94

Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events. PLoS One (2008) 0.94

Variation in heterozygosity predicts variation in human substitution rates between populations, individuals and genomic regions. PLoS One (2013) 0.88

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes. PLoS Genet (2015) 0.85

Mutation biases and mutation rate variation around very short human microsatellites revealed by human-chimpanzee-orangutan genomic sequence alignments. J Mol Evol (2010) 0.85

Selection and mutation in the "new" genetics: an emerging hypothesis. Hum Genet (2010) 0.85

Impacts of mutation effects and population size on mutation rate in asexual populations: a simulation study. BMC Evol Biol (2010) 0.85

Gene conversion in human genetic disease. Genes (Basel) (2010) 0.85

Experimental evolution reveals hidden diversity in evolutionary pathways. Elife (2015) 0.84

Mutation rate, spectrum, topology, and context-dependency in the DNA mismatch repair-deficient Pseudomonas fluorescens ATCC948. Genome Biol Evol (2014) 0.83

Discovery of proteomic code with mRNA assisted protein folding. Int J Mol Sci (2008) 0.82

Using human demographic history to infer natural selection reveals contrasting patterns on different families of immune genes. Proc Biol Sci (2010) 0.82

Starvation-associated genome restructuring can lead to reproductive isolation in yeast. PLoS One (2013) 0.78

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms. Annu Rev Genet (2015) 0.78

Mutational clusters generated by non-processive polymerases: A case study using DNA polymerase betain vitro. DNA Repair (Amst) (2010) 0.78

Evolutionary switches between two serine codon sets are driven by selection. Proc Natl Acad Sci U S A (2016) 0.77

Microsatellite frequencies vary with body mass and body temperature in mammals, suggesting correlated variation in mutation rate. PeerJ (2014) 0.77

Increased substitution rates surrounding low-complexity regions within primate proteins. Genome Biol Evol (2014) 0.76

A generalized mechanistic codon model. Mol Biol Evol (2014) 0.76

Widespread Historical Contingency in Influenza Viruses. Genetics (2016) 0.75

Frail hypotheses in evolutionary biology. PLoS Genet (2010) 0.75

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors. Proc Natl Acad Sci U S A (1987) 4.35

Multiple mutations and cancer. Proc Natl Acad Sci U S A (2003) 4.21

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. J Biol Chem (1985) 3.98

Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene. J Mol Biol (1986) 3.84

Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J Biol Chem (1989) 3.80

A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation. Mol Cell (2005) 2.88

Mechanism of specific LexA cleavage: autodigestion and the role of RecA coprotease. Biochimie (1991) 2.70

Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair. Proc Natl Acad Sci U S A (1988) 2.66

Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates. Genetics (1991) 2.58

Spontaneous mutation in the Escherichia coli lacI gene. Genetics (1991) 2.53

Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells. J Bacteriol (1996) 2.10

Genetic fidelity under harsh conditions: analysis of spontaneous mutation in the thermoacidophilic archaeon Sulfolobus acidocaldarius. Proc Natl Acad Sci U S A (2001) 2.07

Evidence for mutation showers. Proc Natl Acad Sci U S A (2007) 2.00

Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem (2005) 1.94

Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination. Genetics (2000) 1.91

Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy. Mol Microbiol (2004) 1.90

The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae. Mol Gen Genet (1988) 1.82

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. Mutat Res (1989) 1.80

The rate and character of spontaneous mutation in an RNA virus. Genetics (2002) 1.79

Adaptive mutation in Escherichia coli. J Bacteriol (2004) 1.75

Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem (2006) 1.70

Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. J Biol Chem (2000) 1.48

The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. J Biol Chem (1999) 1.46

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Biochemistry (1998) 1.39

Specificity of the mutator effect caused by disruption of the RAD1 excision repair gene of Saccharomyces cerevisiae. J Bacteriol (1990) 1.39

Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. J Biol Chem (1997) 1.37

Clusters of mutations from transient hypermutability. Proc Natl Acad Sci U S A (2005) 1.35

Sequence analysis of spontaneous mutations in a shuttle vector gene integrated into mammalian chromosomal DNA. Proc Natl Acad Sci U S A (1987) 1.26

PURE CLONES OF LACTOSE-NEGATIVE MUTANTS OBTAINED IN ESCHERICHIA COLI AFTER TREATMENT WITH 5-BROMOURACIL. J Mol Biol (1964) 1.21

The mutational specificity of two Escherichia coli dnaE antimutator alleles as determined from lacI mutation spectra. Genetics (1993) 1.19

Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli. J Mol Biol (1991) 1.17

Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. Nucleic Acids Res (1993) 1.15

Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events. Mutat Res (2000) 1.11

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage. Proc Natl Acad Sci U S A (2002) 1.10

An unusual pattern of spontaneous mutations recovered in the halophilic archaeon Haloferax volcanii. Genetics (2006) 1.07

Gene conversion as a focusing mechanism for correlated mutations: a hypothesis. Mol Gen Genet (1996) 1.01

Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo. J Virol (1999) 1.00

Spectra of spontaneous growth-dependent and adaptive mutations at ebgR. J Bacteriol (1999) 1.00

DNA base sequence changes induced by ultraviolet light mutagenesis of a gene on a chromosome in Chinese hamster ovary cells. J Mol Biol (1989) 0.99

Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants. J Virol (2002) 0.98

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem (2002) 0.97

Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele. Genetics (1994) 0.96

Effect of accessory proteins on T4 DNA polymerase replication fidelity. J Mol Biol (1998) 0.96

Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA. Mol Gen Genet (1989) 0.95

Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency. Mutat Res (2004) 0.95

DNA sequence analysis of gamma-radiation (anoxic)-induced and spontaneous lacId mutations in Escherichia coli K-12. Mutat Res (1994) 0.94

Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells. Mutat Res (1990) 0.92

G:C-->T:A and G:C-->C:G transversions are the predominant spontaneous mutations in the Escherichia coli supF gene: an improved lacZ(am) E. coli host designed for assaying pZ189 supF mutational specificity. Mol Gen Genet (1992) 0.91

Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes. Mutagenesis (1993) 0.89

Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ Mol Mutagen (1997) 0.89

Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue Rat2 embryonic fibroblasts. Mutagenesis (1998) 0.88

Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of Big Blue transgenic mice. Environ Mol Mutagen (1999) 0.88

Spectrum of spontaneous HPRT- mutations in TK6 human lymphoblasts. Environ Mol Mutagen (1993) 0.88

Emergence of genetic instability in children treated for leukemia. Science (2000) 0.88

Bromouracil mutagenesis: mispairing or misrepair? Mutat Res (1974) 0.87

Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations. J Virol (2003) 0.87

The spectrum of acridine resistant mutants of bacteriophage T4 reveals cryptic effects of the tsL141 DNA polymerase allele on spontaneous mutagenesis. Genetics (1998) 0.87

Replication fidelity of the supF gene integrated in the thymidine kinase locus of herpes simplex virus type 1. J Virol (2002) 0.85

Implication of uracil in spontaneous mutagenesis on a single-stranded shuttle vector replicated in mammalian cells. Mutat Res (1993) 0.80

Illusory defects and mismatches: why must DNA repair always be (slightly) error prone? Bioessays (2000) 0.80

DNA sequence analysis of spontaneous hprt mutations arising in vivo in cynomolgus monkey T-lymphocytes. Environ Mol Mutagen (1995) 0.79

Chaos and order in spontaneous mutation. Genetics (2006) 0.92