Published in Biotechnol Bioeng on January 01, 2010
Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity. PLoS One (2012) 0.82
de novo design and synthesis of Candida antarctica lipase B gene and α-factor leads to high-level expression in Pichia pastoris. PLoS One (2013) 0.82
Tolerance of a Knotted Near-Infrared Fluorescent Protein to Random Circular Permutation. Biochemistry (2016) 0.75
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Nucleic Acids Res (2004) 1.52
Improving the catalytic activity of Candida antarctica lipase B by circular permutation. J Am Chem Soc (2005) 1.24
Circular permutation: a different way to engineer enzyme structure and function. Trends Biotechnol (2010) 1.16
A second-generation system for unbiased reading frame selection. Protein Eng Des Sel (2004) 1.14
Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. J Mol Biol (2007) 1.12
Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity. Biochemistry (2008) 1.03
Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Res (2009) 0.97
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes. Structure (2007) 0.95
Cu(I)-mediated reductive amination of boronic acids with nitroso aromatics. Org Lett (2004) 0.95
Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. Biochemistry (2010) 0.95
Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation. J Mol Biol (2009) 0.88
Investigating the structural and functional consequences of circular permutation on lipase B from Candida antarctica. Chembiochem (2007) 0.88
Engineering enzymes by 'intelligent' design. Curr Opin Chem Biol (2009) 0.87
Improved biocatalysts from a synthetic circular permutation library of the flavin-dependent oxidoreductase old yellow enzyme. J Am Chem Soc (2013) 0.86
The creation of ITCHY hybrid protein libraries. Methods Mol Biol (2003) 0.85
Recent progress in engineering alpha/beta hydrolase-fold family members. Biotechnol J (2007) 0.84
Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities. J Mol Biol (2007) 0.83
Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2. Biochem Biophys Res Commun (2007) 0.83
Computational design of orthogonal nucleoside kinases. Chem Commun (Camb) (2010) 0.80
1,5-Alpha-D-mannoseptanosides, ring-size isomers that are impervious to alpha-mannosidase-catalyzed hydrolysis. Org Lett (2009) 0.80
On the structural and functional modularity of glycinamide ribonucleotide formyltransferases. Protein Sci (2003) 0.79
Just (protein) engineering? Curr Opin Struct Biol (2013) 0.77
Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography. ACS Chem Biol (2014) 0.77
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases. Bioorg Med Chem Lett (2010) 0.76
Engineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy. Chimia (Aarau) (2009) 0.75
Novel protease inhibitors via computational redesign of subtilisin BPN' propeptide. Biochemistry (2012) 0.75
Truncated FAD synthetase for direct biocatalytic conversion of riboflavin and analogs to their corresponding flavin mononucleotides. Protein Eng Des Sel (2013) 0.75
[Renal failure and recurrent episodes of flash pulmonary edema in a 70-year-old patient]. Dtsch Med Wochenschr (2013) 0.75