Published in Protein Eng Des Sel on October 29, 2013
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol (2002) 2.30
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A (2003) 1.81
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci Transl Med (2012) 1.78
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A (2005) 1.65
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J Am Chem Soc (2010) 1.61
Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase. J Biol Chem (2002) 1.56
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Nucleic Acids Res (2004) 1.52
Bioactive contaminants leach from disposable laboratory plasticware. Science (2008) 1.42
High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae. Protein Expr Purif (2002) 1.32
Improving the catalytic activity of Candida antarctica lipase B by circular permutation. J Am Chem Soc (2005) 1.24
Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins. Biochemistry (2006) 1.21
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem (2005) 1.18
Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase. J Am Chem Soc (2004) 1.17
Circular permutation: a different way to engineer enzyme structure and function. Trends Biotechnol (2010) 1.16
A second-generation system for unbiased reading frame selection. Protein Eng Des Sel (2004) 1.14
Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. J Mol Biol (2007) 1.12
Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy. Biochemistry (2008) 1.08
Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J Med Chem (2004) 1.08
Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane. FEBS Lett (2004) 1.04
Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity. Biochemistry (2008) 1.03
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem (2007) 1.03
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry (2003) 0.99
Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Res (2009) 0.97
Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted. J Am Chem Soc (2011) 0.96
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes. Structure (2007) 0.95
Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. Biochemistry (2010) 0.95
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem (2005) 0.93
High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A. Protein Expr Purif (2009) 0.91
Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation. J Mol Biol (2009) 0.88
Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol (2002) 0.88
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. J Med Chem (2004) 0.88
Investigating the structural and functional consequences of circular permutation on lipase B from Candida antarctica. Chembiochem (2007) 0.88
Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies. Curr Top Med Chem (2011) 0.87
Engineering enzymes by 'intelligent' design. Curr Opin Chem Biol (2009) 0.87
Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Protein Expr Purif (2008) 0.87
Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms. Biochemistry (2007) 0.87
Synthesis and characterization of a collagen model delta-O-phosphohydroxylysine-containing peptide. Anal Biochem (2002) 0.87
Improved biocatalysts from a synthetic circular permutation library of the flavin-dependent oxidoreductase old yellow enzyme. J Am Chem Soc (2013) 0.86
Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis. Proc Natl Acad Sci U S A (2012) 0.86
Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. J Biol Chem (2003) 0.85
The creation of ITCHY hybrid protein libraries. Methods Mol Biol (2003) 0.85
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem (2007) 0.85
The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition. FEBS J (2011) 0.84
Recent progress in engineering alpha/beta hydrolase-fold family members. Biotechnol J (2007) 0.84
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex. J Med Chem (2010) 0.84
Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities. J Mol Biol (2007) 0.83
Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase. Eur J Biochem (2003) 0.83
Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2. Biochem Biophys Res Commun (2007) 0.83
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett (2011) 0.83
²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme. Biochemistry (2011) 0.82
Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B. Biochemistry (2008) 0.82
Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett (2009) 0.81
Structural properties of human monoamine oxidases A and B. Int Rev Neurobiol (2011) 0.81
Improved triglyceride transesterification by circular permuted Candida antarctica lipase B. Biotechnol Bioeng (2010) 0.81
Demonstration of peroxodiferric intermediate in M-ferritin ferroxidase reaction using rapid freeze-quench Mössbauer, resonance Raman, and XAS spectroscopies. Methods Enzymol (2002) 0.81
Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B. Comp Biochem Physiol B Biochem Mol Biol (2011) 0.81
Expression of zebrafish (Danio rerio) monoamine oxidase (MAO) in Pichia pastoris: purification and comparison with human MAO A and MAO B. Protein Expr Purif (2010) 0.81
Dual role of FMN in flavodoxin function: electron transfer cofactor and modulation of the protein-protein interaction surface. Biochim Biophys Acta (2009) 0.81
Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity. J Neurochem (2009) 0.81
Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J Biol Chem (2010) 0.80
Computational design of orthogonal nucleoside kinases. Chem Commun (Camb) (2010) 0.80
1,5-Alpha-D-mannoseptanosides, ring-size isomers that are impervious to alpha-mannosidase-catalyzed hydrolysis. Org Lett (2009) 0.80
Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A. FEBS J (2009) 0.80
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis. Biochemistry (2011) 0.79
On the structural and functional modularity of glycinamide ribonucleotide formyltransferases. Protein Sci (2003) 0.79
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem (2010) 0.78
Development of spin-labeled pargyline analogues as specific inhibitors of human monoamine oxidases A and B. Biochemistry (2009) 0.78
Polystyrene microbridges used in sitting-drop crystallization release 1,4-diphenyl-2-butene, a novel inhibitor of human MAO B. Acta Crystallogr D Biol Crystallogr (2003) 0.78
Just (protein) engineering? Curr Opin Struct Biol (2013) 0.77
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. J Med Chem (2008) 0.77
Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography. ACS Chem Biol (2014) 0.77
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases. Bioorg Med Chem Lett (2010) 0.76
Plasmalogen assembly: a key flavoenzyme. Structure (2007) 0.75
Engineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy. Chimia (Aarau) (2009) 0.75
Generating random circular permutation libraries. Methods Mol Biol (2014) 0.75
[Renal failure and recurrent episodes of flash pulmonary edema in a 70-year-old patient]. Dtsch Med Wochenschr (2013) 0.75
High-level expression and characterization of a highly functional Comamonas acidovorans xanthine dehydrogenase in Pseudomonas aeruginosa. Protein Expr Purif (2004) 0.75
Novel protease inhibitors via computational redesign of subtilisin BPN' propeptide. Biochemistry (2012) 0.75