Published in Biochemistry on March 23, 2010
Tracing determinants of dual substrate specificity in glycoside hydrolase family 5. J Biol Chem (2012) 0.89
Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules. J Biol Chem (2010) 0.85
Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity. PLoS One (2012) 0.82
High-resolution structure prediction of a circular permutation loop. Protein Sci (2011) 0.82
The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation. ACS Synth Biol (2016) 0.77
Improvement in thermostability of metagenomic GH11 endoxylanase (Mxyl) by site-directed mutagenesis and its applicability in paper pulp bleaching process. J Ind Microbiol Biotechnol (2013) 0.76
Engineering of Yarrowia lipolytica lipase Lip8p by circular permutation to alter substrate and temperature characteristics. J Ind Microbiol Biotechnol (2014) 0.75
The response of Greek key proteins to changes in connectivity depends on the nature of their secondary structure. J Mol Biol (2015) 0.75
STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF CIRCULAR PERMUTATION ON THE ACTIVE SITE OF OLD YELLOW ENZYME. ACS Catal (2015) 0.75
Construction of Allosteric Protein Switches by Alternate Frame Folding and Intermolecular Fragment Exchange. Methods Mol Biol (2017) 0.75
Refolding the unfoldable: A systematic approach for renaturation of Bacillus circulans xylanase. Protein Sci (2017) 0.75
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Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat Struct Biol (2002) 3.09
Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis. Science (2007) 2.99
Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem (2011) 2.89
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Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol (2004) 2.51
Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (2005) 2.47
Breakdown of oligosaccharides by the process of elimination. Curr Opin Chem Biol (2006) 2.38
Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A. Nat Struct Biol (2003) 2.31
Structural characterization of the molecular platform for type III secretion system assembly. Nature (2005) 2.20
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. PLoS Pathog (2009) 2.16
Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One (2010) 2.13
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 2.13
Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med (2010) 2.11
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
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Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest (2006) 2.03
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From stem cells to viable autologous semilunar heart valve. Circulation (2005) 1.94
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Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation (2006) 1.89
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Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat Res (2003) 1.88
Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients. J Biol Chem (2004) 1.88
High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol (2007) 1.85
Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. J Biol Chem (2002) 1.83
High-throughput screening methodology for the directed evolution of glycosyltransferases. Nat Methods (2006) 1.81
Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector. Blood (2004) 1.74
Structural perspective of peptidoglycan biosynthesis and assembly. Annu Rev Biochem (2012) 1.69
Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia. Arterioscler Thromb Vasc Biol (2009) 1.64
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis. J Biol Chem (2009) 1.64
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis. Nat Chem Biol (2006) 1.63
Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (2008) 1.62
The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem (2004) 1.62
Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circ Res (2013) 1.61
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science (2013) 1.61
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res (2010) 1.60
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol (2006) 1.59
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Nucleic Acids Res (2004) 1.52
Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism. J Biol Chem (2001) 1.51
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. Nat Struct Mol Biol (2004) 1.50
Engineering of glycosidases and glycosyltransferases. Curr Opin Chem Biol (2006) 1.49
New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition. J Am Chem Soc (2012) 1.46
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature (2008) 1.45
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest (2005) 1.45
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus. Anal Chim Acta (2008) 1.43
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution. J Biol Chem (2003) 1.43
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure (2004) 1.42
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A (2009) 1.41
The solution structure and interactions of CheW from Thermotoga maritima. Nat Struct Biol (2002) 1.41
Structural analysis of a prototypical ATPase from the type III secretion system. Nat Struct Mol Biol (2007) 1.40
Next-generation sequencing in the clinic: promises and challenges. Cancer Lett (2012) 1.39
Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. J Immunol (2007) 1.37
Structural characterization of a type III secretion system filament protein in complex with its chaperone. Nat Struct Mol Biol (2004) 1.37
Circulating succinate is elevated in rodent models of hypertension and metabolic disease. Am J Hypertens (2007) 1.35
Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin. J Pathol (2003) 1.35
Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985) (2002) 1.34
Structural and biochemical identification of a novel bacterial oxidoreductase. J Biol Chem (2004) 1.30
Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A (2005) 1.28
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. Chembiochem (2008) 1.27
CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli. Mol Microbiol (2005) 1.27
mRNA enrichment protocols determine the quantification characteristics of external RNA spike-in controls in RNA-Seq studies. Sci China Life Sci (2013) 1.26
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. J Biol Chem (2002) 1.26
Emerging methods for the production of homogeneous human glycoproteins. Nat Chem Biol (2009) 1.26
Improving the catalytic activity of Candida antarctica lipase B by circular permutation. J Am Chem Soc (2005) 1.24
Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis. J Biol Chem (2001) 1.23
Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (Escherichia coli). Biochem Cell Biol (2010) 1.23
Structure and biochemical analysis of a secretin pilot protein. EMBO J (2005) 1.22
Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J Biol Chem (2003) 1.21
Crystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosis. J Biol Chem (2004) 1.20
The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proc Natl Acad Sci U S A (2008) 1.20
Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism. Structure (2010) 1.19
The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates. J Biol Chem (2008) 1.19
Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol (2004) 1.18
Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17
Circular permutation: a different way to engineer enzyme structure and function. Trends Biotechnol (2010) 1.16
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. J Biol Chem (2004) 1.16
Picornavirus salivirus/klassevirus in children with diarrhea, China. Emerg Infect Dis (2010) 1.16
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state. Angew Chem Int Ed Engl (2002) 1.14
Insights into the bacterial transferrin receptor: the structure of transferrin-binding protein B from Actinobacillus pleuropneumoniae. Mol Cell (2009) 1.14
A second-generation system for unbiased reading frame selection. Protein Eng Des Sel (2004) 1.14
DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. J Biol Chem (2010) 1.13
Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate. J Biol Chem (2004) 1.13
New structural insights into the bacterial type III secretion system. Trends Biochem Sci (2006) 1.13
Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. J Mol Biol (2007) 1.12
In situ Fenton reagent generated from TiO2/Cu2O composite film: a new way to utilize TiO2 under visible light irradiation. Environ Sci Technol (2007) 1.11