Published in Mol Cell on July 21, 2006
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev (2009) 3.62
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
DNA polymerases and cancer. Nat Rev Cancer (2011) 3.05
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02
Regulation of PCNA-protein interactions for genome stability. Nat Rev Mol Cell Biol (2013) 1.88
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) (2008) 1.74
Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol (2012) 1.72
A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification. J Exp Med (2007) 1.57
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol (2009) 1.54
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.49
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem (2009) 1.48
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells. Mol Cell Biol (2009) 1.29
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem (2009) 1.22
Ubiquitylation and the Fanconi anemia pathway. FEBS Lett (2011) 1.21
Coordinating DNA polymerase traffic during high and low fidelity synthesis. Biochim Biophys Acta (2009) 1.20
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem (2012) 1.16
Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. J Biol Chem (2008) 1.10
Variations on a theme: eukaryotic Y-family DNA polymerases. Biochim Biophys Acta (2009) 1.10
Structural diversity of the Y-family DNA polymerases. Biochim Biophys Acta (2010) 1.10
Translesion DNA synthesis and mutagenesis in eukaryotes. Cold Spring Harb Perspect Biol (2013) 1.09
Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol Cell (2010) 1.05
Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance. DNA Repair (Amst) (2008) 1.03
NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η. Biochemistry (2012) 1.00
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutat Res (2012) 0.99
Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts. DNA Repair (Amst) (2008) 0.98
The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant. Genetics (2010) 0.97
The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site. J Biol Chem (2012) 0.96
Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta. Nucleic Acids Res (2009) 0.94
Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase. Biochemistry (2010) 0.94
Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link. EMBO J (2015) 0.93
Separate roles of structured and unstructured regions of Y-family DNA polymerases. Adv Protein Chem Struct Biol (2009) 0.93
Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites. Mol Biol Cell (2011) 0.92
The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesis. Nucleic Acids Res (2010) 0.91
The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis. J Biol Chem (2011) 0.91
Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis. Biochim Biophys Acta (2009) 0.89
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem (2014) 0.88
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS Genet (2014) 0.88
Eukaryotic DNA polymerase ζ. DNA Repair (Amst) (2015) 0.88
Structural basis of ubiquitin recognition by translesion synthesis DNA polymerase ι. Biochemistry (2010) 0.87
Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains. Genetics (2009) 0.87
Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair (Amst) (2013) 0.86
Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res (2015) 0.86
Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. Mol Cell Biol (2011) 0.86
DNA replication stress: from molecular mechanisms to human disease. Chromosoma (2016) 0.84
Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts. Cell Biochem Biophys (2007) 0.84
RAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damage. Mutat Res (2008) 0.83
The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell (2011) 0.83
Regulation of Saccharomyces cerevisiae DNA polymerase eta transcript and protein. Radiat Environ Biophys (2007) 0.83
Translesion DNA synthesis in the context of cancer research. Cancer Cell Int (2011) 0.82
REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle (2012) 0.82
Keeping chromatin quiet: how nucleosome remodeling restores heterochromatin after replication. Cell Cycle (2011) 0.82
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation. Nucleic Acids Res (2012) 0.81
DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη. Nucleic Acids Res (2013) 0.81
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acids Res (2013) 0.81
Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice. Philos Trans R Soc Lond B Biol Sci (2009) 0.81
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res (2015) 0.80
Structural insights into the assembly of human translesion polymerase complexes. Protein Cell (2012) 0.80
The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. J Biol Chem (2016) 0.80
DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis. Mutat Res (2009) 0.80
Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80
Analysis of CPD ultraviolet lesion bypass in chicken DT40 cells: polymerase η and PCNA ubiquitylation play identical roles. PLoS One (2012) 0.79
Replicating damaged DNA in eukaryotes. Cold Spring Harb Perspect Biol (2013) 0.78
Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis. Biochemistry (2016) 0.78
Functional Evolution of BRCT Domains from Binding DNA to Protein. Evol Bioinform Online (2011) 0.78
REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts. Biochem Biophys Res Commun (2015) 0.77
PCNA tool belts and polymerase bridges form during translesion synthesis. Nucleic Acids Res (2016) 0.77
Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA. Sci Rep (2015) 0.76
Characterization of proliferating cell nuclear antigen (PCNA) from pathogenic yeast Candida albicans and its functional analyses in S. Cerevisiae. BMC Microbiol (2015) 0.76
The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage. PLoS One (2015) 0.76
Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity. Nucleic Acids Res (2016) 0.75
Structure and functional analysis of the BRCT domain of translesion synthesis DNA polymerase Rev1. Biochemistry (2012) 0.75
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res (2014) 0.75
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes (Basel) (2016) 0.75
Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases. Genes (Basel) (2017) 0.75
Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas. Chem Res Toxicol (2016) 0.75
Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo. Oncogenesis (2017) 0.75
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell (2005) 4.02
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res (2012) 3.74
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J (2003) 2.69
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol (2008) 2.48
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J (2009) 2.37
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a. Mol Cell (2008) 2.16
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells. EMBO J (2002) 2.06
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02
Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature (2010) 2.01
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J (2006) 1.97
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res (2007) 1.92
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta. EMBO J (2006) 1.89
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines. Nat Biotechnol (2002) 1.87
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J (2002) 1.82
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol (2002) 1.79
A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies. J Invest Dermatol (2010) 1.78
Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics (2004) 1.76
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa. J Biol Chem (2004) 1.73
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res (2007) 1.68
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet (2010) 1.66
An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol (2007) 1.65
Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci (2005) 1.65
REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA). J Biol Chem (2006) 1.61
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci (2009) 1.59
Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis (2008) 1.58
Postreplication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell (2006) 1.57
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J (2004) 1.56
Y-family DNA polymerases in mammalian cells. Cell Mol Life Sci (2009) 1.56
Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther (2013) 1.55
PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA. J Cell Biol (2008) 1.53
Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol (2005) 1.52
Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) (2004) 1.51
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.49
Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage. J Biol Chem (2002) 1.48
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res (2007) 1.48
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.47
Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst) (2006) 1.46
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci (2008) 1.44
Good news on the horizon: the Open Researcher and Contributor ID (ORCID). DNA Repair (Amst) (2010) 1.44
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli. Genetics (2009) 1.40
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem (2010) 1.40
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse. Mol Cell Biol (2007) 1.36
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol (2005) 1.33
Small-molecule activation of neuronal cell fate. Nat Chem Biol (2008) 1.33
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
SUMO modification of PCNA is controlled by DNA. EMBO J (2008) 1.32
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol (2004) 1.31
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage. Nucleic Acids Res (2005) 1.30
Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol (2006) 1.30
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28
Genetic evidence that the non-homologous end-joining repair pathway is involved in LINE retrotransposition. PLoS Genet (2009) 1.28
Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. J Biol Chem (2002) 1.27
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem (2012) 1.26
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A (2010) 1.25
Association of CaV1.3 L-type calcium channels with Shank. J Neurosci (2005) 1.25