Published in Neoplasia on August 01, 2009
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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18
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Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Cancer Prev Res (Phila) (2012) 0.90
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DNA hypermethylation markers of poor outcome in laryngeal cancer. Clin Epigenetics (2010) 0.87
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The role of epigenetics in resistance to Cisplatin chemotherapy in lung cancer. Cancers (Basel) (2011) 0.86
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Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics. Expert Opin Ther Targets (2013) 0.84
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Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. Oncol Lett (2015) 0.78
Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1. Int J Clin Exp Med (2015) 0.78
HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC. J Cell Mol Med (2014) 0.76
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma. Cell Biosci (2014) 0.76
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. Int J Oncol (2014) 0.76
Dinosaurs and ancient civilizations: reflections on the treatment of cancer. Neoplasia (2010) 0.75
Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells. Cancer Cell Int (2017) 0.75
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Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget (2016) 0.75
Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma. Oncotarget (2016) 0.75
The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression. Mol Cell Proteomics (2015) 0.75
The interconnectedness of cancer cell signaling. Neoplasia (2011) 0.75
BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC Cancer (2015) 0.75
Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway. Oncotarget (2016) 0.75
Reviving the guardian of the genome: Small molecule activators of p53. Pharmacol Ther (2017) 0.75
SIRT1 gene polymorphisms and risk of lung cancer. Cancer Manag Res (2017) 0.75
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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature (2000) 4.93
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med (1995) 2.47
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Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet (2003) 1.77
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell (2004) 1.65
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J (2006) 1.41
Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer (2005) 1.38
The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. J Biol Chem (2004) 1.25
Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma. Cancer Res (2002) 1.23
Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene (1998) 1.15
HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors. Int J Biochem Cell Biol (2008) 1.13
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung Cancer (2007) 1.12
Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. Oncogene (2006) 1.06
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Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. J Biol Chem (2000) 1.02
Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. Oncogene (2007) 0.91
Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer. J Clin Oncol (2005) 0.89
HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast. Cancer Lett (2005) 0.87
Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers. Lung Cancer (2007) 0.86
High frequency of deletion mutations in p53 gene from squamous cell lung cancer patients in Taiwan. Cancer Res (1998) 0.83
Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One (2008) 2.90
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Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun (2009) 2.57
IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest (2011) 2.28
Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res (2009) 2.03
Lung cancer with isolated skip metastasis to an abdominal lymph node. Onkologie (2007) 2.03
Pulmonary cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients. Chest (2006) 2.02
Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer. J Thorac Cardiovasc Surg (2002) 1.86
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer (2006) 1.82
Contralateral recurrence of primary spontaneous pneumothorax. Chest (2007) 1.82
Non-Hodgkin's lymphoma presenting as a large chest wall mass. Ann Thorac Surg (2006) 1.77
Surgical results of synchronous multiple primary lung cancers: similar to the stage-matched solitary primary lung cancers? Ann Thorac Surg (2013) 1.64
Small cell carcinoma of the esophagus: a report of 16 cases from a single institution and literature review. Ann Thorac Surg (2011) 1.62
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res (2008) 1.60
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest (2010) 1.57
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res (2010) 1.52
Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer. Ann Thorac Surg (2007) 1.50
Pulmonary metastasectomy for hepatocellular carcinoma. J Chin Med Assoc (2004) 1.46
Gastric schwannoma. J Chin Med Assoc (2004) 1.44
Falsely decreased HbA1c in a type 2 diabetic patient treated with dapsone. J Formos Med Assoc (2012) 1.43
Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer (2005) 1.38
Effect of formalin fixation on tumor size determination in stage I non-small cell lung cancer. Ann Thorac Surg (2007) 1.34
SLIT2 attenuation during lung cancer progression deregulates beta-catenin and E-cadherin and associates with poor prognosis. Cancer Res (2010) 1.33
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma. Cancer (2007) 1.30
Molecular diagnostic markers for lung cancer in sputum and plasma. Ann N Y Acad Sci (2006) 1.27
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. PLoS One (2010) 1.25
Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia. J Gastrointest Surg (2004) 1.24
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochem Biophys Res Commun (2009) 1.20
Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1. Oral Oncol (2009) 1.17
Pulmonary hamartoma. J Chin Med Assoc (2004) 1.16
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells. J Oncol (2010) 1.13
Is thymectomy necessary in nonmyasthenic patients with early thymoma? J Thorac Oncol (2013) 1.12
hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. J Clin Invest (2010) 1.11
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells. Cancer (2011) 1.09
Induction chemoradiation is not superior to induction chemotherapy alone in stage IIIA lung cancer. Ann Thorac Surg (2012) 1.07
Treatment of empyema and bronchopleural fistula by bovine pericardium and latissimus flap. Ann Thorac Surg (2013) 1.07
Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus. Mod Pathol (2008) 1.07
Isolated cryptococcal thoracic empyema with osteomyelitis of the rib in an immunocompetent host. J Infect (2004) 1.07
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res (2011) 1.05
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin Cancer Res (2007) 1.03
Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study. Cancer (2009) 1.02
SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin. Pathol Oncol Res (2012) 1.02
Management of primary chest wall tumors: 14 years' clinical experience. J Chin Med Assoc (2006) 1.02
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation. Int J Cancer (2014) 1.02
Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J Control Release (2012) 1.01
Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study. World J Gastroenterol (2004) 1.00
Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer. Clin Cancer Res (2005) 1.00
Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction. Anal Biochem (2003) 1.00
Intrathoracic displacement of a fractured humeral head due to blunt trauma. Ann Thorac Cardiovasc Surg (2013) 1.00
Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions. Cancer Res (2011) 0.98
Expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. Dis Markers (2008) 0.97
Middle mediastinal thymoma. Respirology (2007) 0.95
Incremental value of integrated FDG-PET/CT in evaluating indeterminate solitary pulmonary nodule for malignancy. Mol Imaging Biol (2009) 0.95
Longstanding tracheobronchial foreign body in an adult. Respir Care (2011) 0.94
Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1. Breast Cancer Res Treat (2007) 0.94
A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. PLoS One (2010) 0.93
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo. PLoS One (2013) 0.93
Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Lett (2004) 0.93
Gastrointestinal stromal tumor (GIST) of the esophagus detected by positron emission tomography/computed tomography. Dig Dis Sci (2005) 0.93
Prognostic role of PGE2 receptor EP2 in esophageal squamous cell carcinoma. Ann Surg Oncol (2008) 0.93
Correlation of p53, MDM2 and p14(ARF) protein expression in human esophageal squamous cell carcinoma. J Cancer Res Clin Oncol (2009) 0.92
Mesenchymal stem cell-conditioned medium facilitates angiogenesis and fracture healing in diabetic rats. J Tissue Eng Regen Med (2011) 0.92
Comparison of Charlson comorbidity index and Kaplan-Feinstein index in patients with stage I lung cancer after surgical resection. Eur J Cardiothorac Surg (2007) 0.92
Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J Pharmacol Exp Ther (2012) 0.91
The impact of smoking in primary spontaneous pneumothorax. J Thorac Cardiovasc Surg (2009) 0.91
Tracheoesophageal fistula and tracheo-subclavian artery fistula after tracheostomy. Eur J Cardiothorac Surg (2007) 0.91
Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models. Cancer (2008) 0.90
Prognostic factors for mortality following falls from height. Injury (2009) 0.90
An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer. Cancer (2011) 0.89
Managements of locally advanced unresectable thymic epithelial tumors. J Chin Med Assoc (2004) 0.89
Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol (2010) 0.89
Analysis of ethylated thymidine adducts in human leukocyte DNA by stable isotope dilution nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry. Anal Chem (2012) 0.89
Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer. J Clin Oncol (2005) 0.89
Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer. Lung Cancer (2008) 0.89
Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation. Biomaterials (2012) 0.88
Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells. Cancer Lett (2009) 0.88
Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg (2005) 0.87
Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis. J Thorac Oncol (2015) 0.87
Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression. Int J Cancer (2014) 0.87
A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect Dis (2013) 0.87
MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer. Clin Cancer Res (2012) 0.87
Persistently high serum carcinoembryonic antigen levels after surgery indicate poor prognosis in patients with stage I non-small-cell lung cancer. J Surg Res (2010) 0.86
EGFR mutations in malignant pleural effusion of non-small cell lung cancer: a case report. Lung Cancer (2005) 0.86
Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms. J Biol Chem (2012) 0.86
Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers. Lung Cancer (2007) 0.86