SIRT1: Regulator of p53 Deacetylation.

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. Oncotarget (2015) 0.85

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One (2015) 0.84

Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res (2015) 0.80

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. Aging (Albany NY) (2015) 0.78

Ionizing radiation induces immediate protein acetylation changes in human cardiac microvascular endothelial cells. J Radiat Res (2015) 0.76

Sirtainties in pancreatic cancer? Oncoscience (2014) 0.76

Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress. Cell Death Dis (2015) 0.76

The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity. Biochim Biophys Acta (2015) 0.75

Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions. Oncotarget (2016) 0.75

Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells. Oncotarget (2017) 0.75

Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). Cancer Biol Ther (2016) 0.75

Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. Int J Mol Med (2017) 0.75

Synergistic Effect of Expressed miR-128 and Puma Protein on Targeted Induction of Tumor Cell Apoptosis. Iran J Biotechnol (2016) 0.75

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59

Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69

miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88

CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature (2009) 4.83

DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell (1999) 4.07

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell (2007) 3.67

Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des (2009) 3.20

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem (2006) 3.18

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell (2012) 2.96

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res (2006) 2.92

SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem (2001) 2.80

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem (2005) 2.77

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene (2006) 2.74

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47

Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30

NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene (2007) 2.29

SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24

Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A (2001) 2.23

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07

The ups and downs of SIRT1. Trends Biochem Sci (2008) 1.97

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008) 1.78

A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res (2012) 1.52

MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. Clin Exp Med (2012) 1.49

Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med (2012) 1.48

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43

USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell (2012) 1.35

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia (2009) 1.25

Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochem Biophys Res Commun (2009) 1.23

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage. Oncogene (2005) 1.20

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem (2012) 1.19

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX. Biochem Biophys Res Commun (2009) 1.14

Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res (2011) 1.13

Vitamin B3 and sirtuin function. Trends Biochem Sci (2005) 1.12

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12

Sirtuin activators. Expert Opin Ther Pat (2009) 1.10

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell Death Dis (2012) 1.10

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther (2012) 1.09

Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91

Sirtuin activators: designing molecules to extend life span. Biochim Biophys Acta (2010) 0.89

A patent review of sirtuin activators: an update. Expert Opin Ther Pat (2012) 0.89

SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin. Biochem Biophys Res Commun (2012) 0.88

The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals. Mech Ageing Dev (2001) 0.83

Modes of p53 regulation. Cell (2009) 9.31

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70

Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70

Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50

p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50

Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18

Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10

Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09

Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08

Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08

New insights into p53 activation. Cell Res (2010) 1.06

Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04

Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04

Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03

Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02

SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

Adhesive water networks facilitate binding of protein interfaces. Nat Commun (2011) 1.00

p53 Activation: a case against Sir. Cancer Cell (2008) 0.99

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. Crit Care (2009) 0.98

A critical role for noncoding 5S rRNA in regulating Mdmx stability. Mol Cell (2011) 0.98

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Cell Res (2013) 0.98

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.98

An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice. Mol Pharmacol (2009) 0.97

RNA asymmetric distribution and daughter/mother differentiation in yeast. Curr Opin Microbiol (2003) 0.97

An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation. J Biol Chem (2014) 0.96

Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor. Hum Pathol (2010) 0.95

Identification of haplotype tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma. Shock (2011) 0.95

Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation. J Biol Chem (2007) 0.94

Urinary proteomics as a novel tool for biomarker discovery in kidney diseases. J Zhejiang Univ Sci B (2010) 0.93

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther (2009) 0.92

Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma. Shock (2010) 0.92

Clinical observations on the association between diagnosis of lung cancer and serum tumor markers in combination. Asian Pac J Cancer Prev (2013) 0.92

Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin. Onkologie (2006) 0.91