Why is p53 acetylated?

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38

Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29

Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84

The expanding universe of p53 targets. Nat Rev Cancer (2009) 3.49

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell (2012) 2.96

Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J (2003) 2.67

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol (2004) 2.61

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A (2003) 2.21

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol (2006) 2.21

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol (2005) 2.13

Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol Cell Biol (2003) 1.89

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol (2002) 1.83

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79

The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol (2002) 1.48

Autoacetylation of the Ralstonia solanacearum effector PopP2 targets a lysine residue essential for RRS1-R-mediated immunity in Arabidopsis. PLoS Pathog (2010) 1.36

A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol (2011) 1.35

The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Mol Cell Biol (2003) 1.33

ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol (2005) 1.31

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia (2009) 1.25

p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol (2006) 1.20

HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. EMBO J (2004) 1.17

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J (2004) 1.16

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure (2011) 1.13

Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx. J Virol (2003) 1.08

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol (2006) 1.07

Myosin VI is a mediator of the p53-dependent cell survival pathway. Mol Cell Biol (2006) 1.04

p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PLoS One (2007) 1.04

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol (2010) 1.03

The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine. Genes Cancer (2011) 1.02

Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation. BMC Biol (2004) 1.00

Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab (2012) 0.98

p53 RNA interactions: new clues in an old mystery. RNA (2007) 0.97

p53 Acetylation: Regulation and Consequences. Cancers (Basel) (2014) 0.97

Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Nucleic Acids Res (2011) 0.95

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood (2013) 0.93

High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. Sci Rep (2014) 0.93

Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer (2004) 0.93

Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene (2014) 0.89

Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells. Invest New Drugs (2010) 0.89

Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Mutat Res (2007) 0.87

Regulation of ERK1 gene expression by coactivator proteins. Biochem J (2005) 0.87

The biology of lysine acetylation integrates transcriptional programming and metabolism. Nutr Metab (Lond) (2011) 0.87

Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer. J Histochem Cytochem (2013) 0.86

Acetylation of conserved lysines in bovine papillomavirus E2 by p300. J Virol (2012) 0.85

Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases. J Biomed Biotechnol (2006) 0.83

Transcriptional activators and activation mechanisms. Protein Cell (2011) 0.81

Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase. Nucleic Acids Res (2002) 0.80

FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53. J Virol (2015) 0.80

Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol (2015) 0.79

Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition. Exp Hematol (2016) 0.79

Identification of new p53 acetylation sites in COS-1 cells. Mol Cell Proteomics (2009) 0.79

Out of the jaws of death: PRMT5 steers p53. Nat Cell Biol (2008) 0.79

ModuleBlast: identifying activated sub-networks within and across species. Nucleic Acids Res (2014) 0.78

The Role of HDACs as Leukemia Therapy Targets using HDI. Int J Hematol Oncol Stem Cell Res (2015) 0.75

Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study. PLoS One (2015) 0.75

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proc Natl Acad Sci U S A (1980) 24.21

DNA sequence required for initiation of transcription in vitro from the major late promoter of adenovirus 2. Proc Natl Acad Sci U S A (1981) 9.08

Mechanism and regulation of mRNA polyadenylation. Genes Dev (1997) 7.48

In vitro transcription of adenovirus. J Virol (1981) 7.06

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature (1994) 6.97

RNA polymerase II and the integration of nuclear events. Genes Dev (2000) 6.16

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell (1990) 5.92

Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell (1991) 5.72

Transcriptional repression of eukaryotic promoters. Cell (1989) 5.60

The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell (1996) 4.93

RNA polymerase II is an essential mRNA polyadenylation factor. Nature (1998) 4.87

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J (1995) 4.66

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65

Structure and in vitro transcription of human globin genes. Science (1980) 4.65

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature (2000) 4.36

In vitro transcription: whole-cell extract. Methods Enzymol (1983) 4.07

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing. Genes Dev (1989) 3.95

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev (1997) 3.87

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. Genes Dev (1988) 3.80

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell (1989) 3.77

RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor. Proc Natl Acad Sci U S A (1979) 3.75

Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysate. Cell (1983) 3.68

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. Genes Dev (1990) 3.43

Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA. Nature (1997) 3.39

The ends of the affair: capping and polyadenylation. Nat Struct Biol (2000) 3.31

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation. Cell (1988) 3.16

Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol Cell (1998) 3.02

Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell (1989) 3.01

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev (1999) 3.00

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev (1996) 2.99

Four factors are required for 3'-end cleavage of pre-mRNAs. Genes Dev (1989) 2.89

RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo. J Mol Biol (1979) 2.86

RNA recognition by the human polyadenylation factor CstF. Mol Cell Biol (1997) 2.84

The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Genes Dev (1995) 2.83

Splicing-related catalysis by protein-free snRNAs. Nature (2001) 2.83

Functional domains of the human splicing factor ASF/SF2. EMBO J (1993) 2.83

Functional domains of the Drosophila Engrailed protein. EMBO J (1993) 2.73

Determinants of SR protein specificity. Curr Opin Cell Biol (1999) 2.72

Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing. Mol Cell Biol (1985) 2.68

Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. Genes Dev (1993) 2.67

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA (1995) 2.60

In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. J Biol Chem (1984) 2.58

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. Proc Natl Acad Sci U S A (1981) 2.58

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes Dev (1998) 2.56

Complex protein interactions within the human polyadenylation machinery identify a novel component. Mol Cell Biol (2000) 2.55

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus. J Biol Chem (1992) 2.51

High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev (1998) 2.40

Factors influencing alternative splice site utilization in vivo. Mol Cell Biol (1987) 2.39

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J (1998) 2.37

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A (1997) 2.34

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev (1996) 2.33

Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA. Nature (1991) 2.30

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. Genes Dev (1995) 2.29

Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell (1998) 2.25

Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol Cell (2000) 2.21

The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. Proc Natl Acad Sci U S A (1992) 2.15

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14

The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09

TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters. Genes Dev (1992) 2.08

A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. Nature (1994) 2.03

The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell (2001) 1.95

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Genes Dev (1992) 1.90

Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. Mol Cell (2001) 1.85

Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. Genes Dev (1998) 1.85

A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates. Mol Cell Biol (1990) 1.84

Primary structure and expression of bovine poly(A) polymerase. Nature (1991) 1.84

RNA sequence containing hexanucleotide AAUAAA directs efficient mRNA polyadenylation in vitro. Mol Cell Biol (1985) 1.81

A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal. Cell (1989) 1.80

U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res (1995) 1.77

Synthesis and degradation of termination and premature-termination fragments of beta-galactosidase in vitro and in vivo. J Mol Biol (1978) 1.76

Sequence specificity of the human mRNA N6-adenosine methylase in vitro. Nucleic Acids Res (1990) 1.73

Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. EMBO J (1992) 1.70

Selective translation initiation on bicistronic simian virus 40 late mRNA. J Virol (1987) 1.70

Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Nature (1996) 1.69

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell (1984) 1.69

Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter. Nucleic Acids Res (1984) 1.68

RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence. Mol Cell Biol (1989) 1.67

Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly. Mol Cell Biol (1989) 1.67

Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science (1999) 1.67

Interaction between a transcriptional activator and transcription factor IIB in vivo. Nature (1993) 1.66

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing. EMBO J (1988) 1.66

Control of adenovirus late promoter expression in two human cell lines. Mol Cell Biol (1985) 1.66

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. Nucleic Acids Res (1993) 1.65

Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro. Mol Cell Biol (1987) 1.65

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression. Proc Natl Acad Sci U S A (1982) 1.65

Regulation of pre-mRNA splicing in metazoa. Curr Opin Genet Dev (1997) 1.59

The transcriptional repressor even-skipped interacts directly with TATA-binding protein. Mol Cell Biol (1995) 1.59

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites. Cell (1987) 1.57

Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells. Genes Dev (1991) 1.47

A human polyadenylation factor is a G protein beta-subunit homologue. J Biol Chem (1992) 1.44

A novel protein factor is required for use of distal alternative 5' splice sites in vitro. Mol Cell Biol (1991) 1.43

Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. Genes Dev (1988) 1.42

Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells. Nature (1985) 1.42

In vitro splicing of simian virus 40 early pre mRNA. Nucleic Acids Res (1986) 1.40

Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA. Mol Cell Biol (1988) 1.39

Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation. Mol Cell Biol (1989) 1.31

Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Mol Cell Biol (1996) 1.31

Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol (1996) 1.30

Multiple activities of the human splicing factor ASF. Gene Expr (1992) 1.27

Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. EMBO J (1998) 1.26