Published in Autophagy on October 14, 2009
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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest (2008) 10.74
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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet (2009) 7.26
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009) 3.23
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02
Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci (2010) 2.73
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci (2005) 2.31
Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet (2010) 2.22
The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem (2007) 1.99
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The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell (2006) 1.85
Dissemination of methicillin-resistant Staphylococcus aureus USA300 sequence type 8 lineage in Latin America. Clin Infect Dis (2009) 1.77
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain (2010) 1.77
The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci (2007) 1.68
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology (2012) 1.66
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res (2006) 1.66
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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest (2003) 1.61
TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. J Biol Chem (2003) 1.61
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev (2008) 1.61
TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene (2005) 1.58
A metabolic prosurvival role for PML in breast cancer. J Clin Invest (2012) 1.57
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. PLoS Genet (2009) 1.55
Silicon chips detect intracellular pressure changes in living cells. Nat Nanotechnol (2013) 1.55
The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell (2008) 1.54
The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci (2012) 1.53
The endocannabinoid system drives neural progenitor proliferation. FASEB J (2005) 1.51
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain (2009) 1.50
An anti-apoptotic viral protein that recruits Bax to mitochondria. J Biol Chem (2004) 1.49
Prevalence of the metabolic syndrome in San Juan, Puerto Rico. Ethn Dis (2008) 1.47
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A (2008) 1.47
Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Sci Signal (2009) 1.47
Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function. Cancer Res (2009) 1.46
Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. Biochem Biophys Res Commun (2002) 1.46
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci Signal (2011) 1.43
Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer (2012) 1.41
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem (2010) 1.39
Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal (2009) 1.39
Genomic analysis of the emergence and evolution of multidrug resistance during a Klebsiella pneumoniae outbreak including carbapenem and colistin resistance. J Antimicrob Chemother (2013) 1.39
P53-dependent expression of the stress-induced protein (SIP). Eur J Cell Biol (2002) 1.36
Inhibition of tumor angiogenesis by cannabinoids. FASEB J (2003) 1.36
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A (2009) 1.34
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells. J Neurosci (2006) 1.33
High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis. Cancer Res (2012) 1.32
Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J (2006) 1.28
Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J (2006) 1.25
Balance between autophagic pathways preserves retinal homeostasis. Aging Cell (2013) 1.23
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res (2006) 1.22
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. J Exp Med (2005) 1.22
Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells. Pancreatology (2010) 1.21
A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genet (2012) 1.20
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J Biol Chem (2008) 1.18
A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther (2011) 1.17