Published in Dig Dis Sci on August 06, 2009
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci (2012) 1.61
Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther (2010) 1.08
Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype. BMC Gastroenterol (2010) 0.93
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Lubiprostone stimulates small intestinal mucin release. BMC Gastroenterol (2012) 0.84
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Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 1.94
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Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology (2009) 1.59
Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol (2008) 1.54
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Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther (2008) 1.50
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Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol (2006) 1.17
Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol (2009) 1.12
A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. Am J Physiol Gastrointest Liver Physiol (2005) 1.08
ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology (2004) 1.03
Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol (2009) 1.02
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models. J Biol Chem (2004) 0.99
The chloride channel ClC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia. J Biol Chem (2001) 0.97
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Is the ClC-2 chloride channel involved in the Cl- secretory mechanism of gastric parietal cells? FEBS Lett (2004) 0.84
Clinical pharmacology of lubiprostone, a chloride channel activator in defecation disorders. Expert Opin Drug Metab Toxicol (2008) 0.84
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology (2007) 1.73
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Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol (2007) 1.24
Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol (2009) 1.24
Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol (2006) 1.17
Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther (2011) 1.12
Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol (2009) 1.11
A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. Am J Physiol Gastrointest Liver Physiol (2005) 1.08
Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology (2006) 1.03
Luminal chemosensing and upper gastrointestinal mucosal defenses. Am J Clin Nutr (2009) 1.02
Lafutidine, a protective H₂ receptor antagonist, enhances mucosal defense in rat esophagus. Dig Dis Sci (2010) 1.00
NHE3 inhibition activates duodenal bicarbonate secretion in the rat. Am J Physiol Gastrointest Liver Physiol (2003) 0.97
Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery. World J Gastroenterol (2007) 0.97
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol (2012) 0.96
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Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum. Gastroenterology (2004) 0.94
Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution. FEBS Lett (2005) 0.94
Gastric cancer mimicking a submucosal tumor diagnosed by laparoscopic excision biopsy. J Laparoendosc Adv Surg Tech A (2005) 0.93
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Histological complete response in a case of advanced gastric cancer treated by chemotherapy with S-1 plus low-dose cisplatin and radiation. Jpn J Clin Oncol (2003) 0.90
Evaluation of a pharmacist-managed hepatitis C care clinic. Am J Health Syst Pharm (2007) 0.89
Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci (2013) 0.89
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Mechanism of augmented duodenal HCO(3)(-) secretion after elevation of luminal CO(2). Am J Physiol Gastrointest Liver Physiol (2004) 0.87
CFTR inhibition augments NHE3 activity during luminal high CO2 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol (2008) 0.87
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Short-chain fatty acid sensing in rat duodenum. J Physiol (2015) 0.86
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Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity. Dig Dis Sci (2013) 0.85
Significant role of ceramide pathway in experimental gastric ulcer formation in rats. J Pharmacol Exp Ther (2003) 0.84
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Low-dose PGE2 mimics the duodenal secretory response to luminal acid in mice. Am J Physiol Gastrointest Liver Physiol (2004) 0.82
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The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice. J Gastroenterol Hepatol (2015) 0.82
Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration. Am J Physiol Gastrointest Liver Physiol (2009) 0.81
Unusual complication: superior mesenteric artery syndrome and closed loop gastroduodenal obstruction after adjustable gastric banding. Surg Obes Relat Dis (2010) 0.81
Duodenal chemosensing: master control for epigastric sensation? J Gastroenterol Hepatol (2011) 0.80
Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther (2010) 0.80
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Cyclooxygenase (COX)-1 and COX-2 both play an important role in the protection of the duodenal mucosa in cats. J Pharmacol Exp Ther (2012) 0.79
Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion. Clin Hemorheol Microcirc (2006) 0.78
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Luminal acid elicits a protective duodenal mucosal response. Keio J Med (2002) 0.77
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May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci (2012) 0.76
Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats. Peptides (2005) 0.76
A novel phosphorus repletion strategy in a patient with duodenal perforation. Nutr Clin Pract (2014) 0.76
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CRC screening, past, present, and future: a tribute to Emmet Keeffe. Dig Dis Sci (2015) 0.76
Gastroduodenal mucosal defense: an integrated protective response. Curr Opin Gastroenterol (2003) 0.76
Peripheral corticotropin-releasing factor receptor type 2 activation increases colonic blood flow through nitric oxide pathway in rats. Dig Dis Sci (2015) 0.76
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From bedside to bench: reverse engineering medical progress. Dig Dis Sci (2012) 0.75
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Prostaglandin pathways in duodenal chemosensing. J Gastroenterol Hepatol (2014) 0.75
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Compounded bioidentical hormone therapy: time for a reality check? Menopause (2015) 0.75
Gastroduodenal mucosal defense. Curr Opin Gastroenterol (2012) 0.75
Introduction to the "GRG Scholars Invited Reviews". Dig Dis Sci (2013) 0.75
Gastrointestinal defense mechanisms. Curr Opin Gastroenterol (2016) 0.75
Bringing the Bacon home. Dig Dis Sci (2013) 0.75
Luminal chemosensing in the gastroduodenal mucosa. Curr Opin Gastroenterol (2017) 0.75
Covering digestive diseases and sciences: how to judge a journal by its cover. Dig Dis Sci (2013) 0.75
Personal reminiscences about Morton Grossman and the founding of the Center for Ulcer Research and Education (CURE). Am J Physiol Gastrointest Liver Physiol (2008) 0.75
Role of protein kinases on acid-induced duodenal bicarbonate secretion in rats. Pharmacology (2003) 0.75