Published in BMC Gastroenterol on September 15, 2010
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci (2012) 1.61
The cystic fibrosis intestine. Cold Spring Harb Perspect Med (2013) 0.98
Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome. Dig Dis Sci (2011) 0.91
Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome. Gut Microbes (2012) 0.90
Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)). Biochem Biophys Res Commun (2012) 0.86
Lubiprostone stimulates small intestinal mucin release. BMC Gastroenterol (2012) 0.84
May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci (2012) 0.76
Swimming through the gut: implications of fluid transport on the microbiome. Dig Dis Sci (2013) 0.75
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
NCBI GEO: archive for high-throughput functional genomic data. Nucleic Acids Res (2008) 17.35
A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Anal Biochem (2002) 5.02
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest (2009) 2.37
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol (2004) 2.33
Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 1.94
Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology (2009) 1.59
Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol (2008) 1.54
Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine. Infect Immun (2004) 1.53
Inflammation of the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2004) 1.40
A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.35
Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol (2007) 1.25
GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene (2007) 1.21
Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2007) 1.17
Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion. Gastroenterology (2006) 1.17
Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.14
Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol (2009) 1.12
Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects. Am J Physiol Gastrointest Liver Physiol (2008) 1.09
Risk factors for small bowel bacterial overgrowth in cystic fibrosis. J Pediatr Gastroenterol Nutr (2007) 1.08
Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol (2004) 1.07
Enteric nervous system: sensory physiology, diarrhea and constipation. Curr Opin Gastroenterol (2010) 1.06
Localization of ClC-2 Cl- channels in rabbit gastric mucosa. Am J Physiol Cell Physiol (2001) 1.06
Effects of lubiprostone on human uterine smooth muscle cells. Prostaglandins Other Lipid Mediat (2008) 1.05
Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig Dis Sci (2009) 1.03
Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. Br J Pharmacol (2007) 1.03
Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol (2009) 1.02
Altered transit and bacterial overgrowth in the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2007) 1.01
Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane. Am J Physiol (1996) 0.98
The pathology of meconium ileus equivalent. J Clin Pathol (1983) 0.97
Salmeterol restores secretory functions in cystic fibrosis airway submucosal gland serous cells. Am J Respir Cell Mol Biol (2008) 0.94
Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulation. J Pediatr Gastroenterol Nutr (2006) 0.92
Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis. Am J Physiol Gastrointest Liver Physiol (2006) 0.92
Lubiprostone neither decreases gastric and small-bowel transit time nor improves visualization of small bowel for capsule endoscopy: a double-blind, placebo-controlled study. Gastrointest Endosc (2009) 0.91
Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series. Ann Pharmacother (2010) 0.90
Altered eicosanoid metabolism in the cystic fibrosis mouse small intestine. J Pediatr Gastroenterol Nutr (2008) 0.88
Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10. BMC Genet (2005) 0.87
Electrogastrography reveals post-prandial gastric dysmotility in children with cystic fibrosis. J Pediatr Gastroenterol Nutr (2004) 0.83
Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse. PLoS One (2009) 0.82
Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium. Int J Parasitol (2007) 0.79
Statistical limitations of percent ideal body weight as measure for nutritional failure in patients with cystic fibrosis. J Cyst Fibros (2009) 0.77
Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2007) 1.17
Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects. J Am Soc Nephrol (2007) 1.10
Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse. J Pediatr Gastroenterol Nutr (2011) 0.89
Altered eicosanoid metabolism in the cystic fibrosis mouse small intestine. J Pediatr Gastroenterol Nutr (2008) 0.88
Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granules. Am J Physiol Cell Physiol (2005) 0.85
Predictors of acute posttraumatic stress disorder symptoms following civilian trauma: highest incidence and severity of symptoms after assault. J Trauma Acute Care Surg (2012) 0.83
Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse. PLoS One (2009) 0.82
Intestinal smooth muscle dysfunction develops postnatally in cystic fibrosis mice. J Pediatr Gastroenterol Nutr (2012) 0.81
How to assess phenytoin levels. Nursing (2005) 0.75