Published in J Cell Sci on September 15, 2005
Chloride channels as drug targets. Nat Rev Drug Discov (2008) 3.22
The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proc Natl Acad Sci U S A (2007) 1.24
Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion. J Physiol (2008) 1.24
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons. J Physiol (2009) 1.16
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.14
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4. J Physiol (2007) 1.11
Colonic potassium handling. Pflugers Arch (2010) 1.08
Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig Dis Sci (2009) 1.03
Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. Br J Pharmacol (2007) 1.03
Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem (2010) 1.03
Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig Dis Sci (2010) 1.00
Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Dig Dis Sci (2010) 1.00
Murine mCLCA6 is an integral apical membrane protein of non-goblet cell enterocytes and co-localizes with the cystic fibrosis transmembrane conductance regulator. J Histochem Cytochem (2008) 0.98
Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels. J Physiol (2010) 0.97
A conserved hydrophobic tetrad near the C terminus of the secretory Na+-K+-2Cl- cotransporter (NKCC1) is required for its correct intracellular processing. J Biol Chem (2009) 0.97
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol (2008) 0.94
Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells. J Mol Cell Cardiol (2009) 0.94
Physiology and pathophysiology of ClC-K/barttin channels. Front Physiol (2010) 0.87
Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels. Gastroenterology (2011) 0.87
Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol (2013) 0.85
Activation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion. Exp Physiol (2010) 0.83
Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon. Am J Physiol Cell Physiol (2012) 0.82
The secretory KCa1.1 channel localises to crypts of distal mouse colon: functional and molecular evidence. Pflugers Arch (2011) 0.80
Putative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency. J Pharmacol Exp Ther (2009) 0.80
The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif. PLoS One (2013) 0.78
Basolateral sorting of chloride channel 2 is mediated by interactions between a dileucine motif and the clathrin adaptor AP-1. Mol Biol Cell (2015) 0.77
Prolactin and dexamethasone regulate second messenger-stimulated cl(-) secretion in mammary epithelia. J Signal Transduct (2012) 0.76
The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane. Am J Physiol Cell Physiol (2012) 0.76
A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa. Pharmacol Res Perspect (2015) 0.76
May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci (2012) 0.76
Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells. Physiol Rep (2015) 0.76
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies. Front Pharmacol (2017) 0.75
Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome. Mol Cell Pediatr (2016) 0.75
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet (2006) 4.01
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res (2009) 1.97
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem (2004) 1.81
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem (2006) 1.70
Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl (2009) 1.51
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol (2006) 1.51
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. Physiol Genomics (2004) 1.37
Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem (2002) 1.34
A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel. J Physiol (2003) 1.32
The voltage-dependent ClC-2 chloride channel has a dual gating mechanism. J Physiol (2004) 1.29
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel. Proc Natl Acad Sci U S A (2006) 1.27
The NHX family of Na+-H+ exchangers in Caenorhabditis elegans. J Biol Chem (2002) 1.27
Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons. J Physiol (2002) 1.25
Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes. Blood (2002) 1.19
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons. J Physiol (2009) 1.16
Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer. Circulation (2004) 1.15
Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride. Gastroenterology (2004) 1.15
Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex. Proc Natl Acad Sci U S A (2007) 1.13
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4. J Physiol (2007) 1.11
Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. J Biol Chem (2008) 1.11
Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol (2009) 1.11
Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands. J Physiol (2007) 1.09
Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J Immunol (2008) 1.06
Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem (2006) 1.02
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain. J Physiol (2006) 1.02
Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol (2007) 1.00
Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH. J Biol Chem (2010) 0.96
Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel. J Physiol (2002) 0.96
Cellular expression of plasma prekallikrein in human tissues. Biol Chem (2007) 0.96
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K⁺ channels. J Physiol (2011) 0.95
Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland. Am J Physiol Cell Physiol (2008) 0.95
Elevated incidence of dental caries in a mouse model of cystic fibrosis. PLoS One (2011) 0.95
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol (2008) 0.94
Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene. J Physiol (2002) 0.94
A novel chloride conductance activated by extracellular ATP in mouse parotid acinar cells. J Physiol (2002) 0.94
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization. Am J Physiol Gastrointest Liver Physiol (2002) 0.93
The salivary gland fluid secretion mechanism. J Med Invest (2009) 0.92
Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity. Mol Membr Biol (2003) 0.92
Quantitative analysis of age specific variation in the abundance of human female parotid salivary proteins. J Proteome Res (2009) 0.92
Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol (2003) 0.92
Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem (2007) 0.90
Quantitative salivary proteomic differences in oral chronic graft-versus-host disease. J Clin Immunol (2012) 0.89
A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands. J Membr Biol (2008) 0.88
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter. PLoS One (2011) 0.88
Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels. Gastroenterology (2011) 0.87
Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface. J Proteome Res (2010) 0.87
The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. Am J Physiol Cell Physiol (2009) 0.86
Na+ modulates anion permeation and block of P2X7 receptors from mouse parotid glands. J Membr Biol (2008) 0.85
Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells. Cancer Lett (2010) 0.85
Age and gender related differences in human parotid gland gene expression. Arch Oral Biol (2008) 0.85
Characterization of the human submandibular/sublingual saliva glycoproteome using lectin affinity chromatography coupled to multidimensional protein identification technology. J Proteome Res (2011) 0.84
Differential distribution of the vasopressin V receptor along the rat nephron during renal ontogeny and maturation. Kidney Int (2005) 0.84
Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium. Exp Physiol (2010) 0.84
An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH. J Biol Chem (2013) 0.84
No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy. Nat Genet (2010) 0.84
Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family. J Leukoc Biol (2009) 0.83
Acute inflammation alters bicarbonate transport in mouse ileum. J Physiol (2007) 0.83
Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. J Leukoc Biol (2008) 0.83
Stimulation of the bradykinin B(1) receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway. Breast Cancer Res Treat (2009) 0.83
Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2003) 0.83
ClC-5 mutations associated with Dent's disease: a major role of the dimer interface. Pflugers Arch (2011) 0.83
TASK-2 K₂p K⁺ channel: thoughts about gating and its fitness to physiological function. Pflugers Arch (2014) 0.82
Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl- channels. Mol Membr Biol (2006) 0.82
Expression of kallikrein, bradykinin b2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta. Endocrine (2006) 0.82
Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. J Cell Physiol (2009) 0.82
Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways. Cell Signal (2008) 0.82