Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

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Published in Bioorg Med Chem Lett on July 23, 2009

Authors

Anh P Truong1, Danielle L Aubele, Gary D Probst, Martin L Neitzel, Chris M Semko, Simeon Bowers, Darren Dressen, Roy K Hom, Andrei W Konradi, Hing L Sham, Albert W Garofalo, Pamela S Keim, Jing Wu, Michael S Dappen, Karina Wong, Erich Goldbach, Kevin P Quinn, John-Michael Sauer, Elizabeth F Brigham, William Wallace, Lan Nguyen, Susanna S Hemphill, Michael P Bova, Frédérique Bard, Ted A Yednock, Guriqbal Basi

Author Affiliations

1: Department of Medicinal Chemistry, Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, CA 94080, USA.

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