Published in Development on September 01, 2009
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS One (2009) 1.69
Eye morphogenesis and patterning of the optic vesicle. Curr Top Dev Biol (2010) 1.60
PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet (2014) 1.52
Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron (2012) 1.37
Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development (2013) 1.16
Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development (2010) 1.15
Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development (2011) 1.15
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (2011) 1.07
The cellular and molecular mechanisms of vertebrate lens development. Development (2014) 1.04
The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Dev Biol (2011) 1.04
The function of FGF signaling in the lens placode. Dev Biol (2011) 1.01
HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet (2014) 1.00
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development (2013) 0.95
Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level. Bioessays (2011) 0.90
Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci (2011) 0.88
Pax2 coordinates epithelial morphogenesis and cell fate in the inner ear. Dev Biol (2010) 0.88
Eye development and retinogenesis. Cold Spring Harb Perspect Biol (2012) 0.87
Lens induction requires attenuation of ERK signaling by Nf1. Hum Mol Genet (2011) 0.87
IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells. Stem Cells (2015) 0.85
MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. EMBO J (2014) 0.84
Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2. PLoS One (2012) 0.82
Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators. Mol Vis (2015) 0.81
Which FGF ligands are involved in lens induction? Dev Biol (2009) 0.81
Shaping the eye from embryonic stem cells: Biological and medical implications. World J Stem Cells (2012) 0.80
The role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration. Evodevo (2014) 0.80
Regulation of cadherin expression in nervous system development. Cell Adh Migr (2013) 0.79
Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses. Hum Genomics (2012) 0.77
Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development (2015) 0.77
A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo. Dis Model Mech (2016) 0.75
The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6. PLoS Genet (2016) 0.75
A trans-Regulatory Code for the Forebrain Expression of Six3.2 in the Medaka Fish. J Biol Chem (2015) 0.75
Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol (2014) 0.75
Signaling and Gene Regulatory Networks in Mammalian Lens Development. Trends Genet (2017) 0.75
The role of chromatin during transcription. Cell (2007) 26.48
Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev (2003) 12.38
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science (1995) 7.35
Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature (1992) 6.32
Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science (1994) 5.75
Mutations in SOX2 cause anophthalmia. Nat Genet (2003) 5.03
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev (2006) 4.11
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet (2000) 3.82
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Early eye development in vertebrates. Annu Rev Cell Dev Biol (2001) 3.21
The role of Pax-6 in eye and nasal development. Development (1995) 3.00
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet (1996) 2.75
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
PAX-6 in development and evolution. Annu Rev Neurosci (1997) 2.68
BMP4 is essential for lens induction in the mouse embryo. Genes Dev (1998) 2.62
Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res (2005) 2.44
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res (2005) 2.44
Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals. Dev Cell (2003) 2.43
Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev (2001) 2.18
Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Development (1998) 2.11
Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev (1995) 2.09
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development (2003) 2.09
Pax6 induces ectopic eyes in a vertebrate. Development (1999) 1.97
Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development (2000) 1.87
Regulation of Pax6 expression is conserved between mice and flies. Development (1999) 1.87
Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development (2004) 1.79
The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol (2005) 1.74
Pathways regulating lens induction in the mouse. Int J Dev Biol (2004) 1.68
Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J (2006) 1.64
Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2. Clin Genet (2006) 1.62
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol (2008) 1.53
A highly conserved lens transcriptional control element from the Pax-6 gene. Mech Dev (1998) 1.44
SOX2 anophthalmia syndrome: 12 new cases demonstrating broader phenotype and high frequency of large gene deletions. Br J Ophthalmol (2007) 1.44
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development (2007) 1.33
Dosage requirement and allelic expression of PAX6 during lens placode formation. Development (2000) 1.33
Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development (2001) 1.27
Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development (2000) 1.27
Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett (2008) 1.26
The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development (2001) 1.26
Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev (1997) 1.24
Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation. Int J Dev Biol (2004) 1.22
Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol (2006) 1.19
Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant. Differentiation (1994) 1.15
Foxe view of lens development and disease. Development (2007) 1.09
PAX6 and SOX2-dependent regulation of the Sox2 enhancer N-3 involved in embryonic visual system development. Genes Cells (2007) 1.04
How to make an eye. Development (2004) 0.93
Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development. Dev Biol (2005) 0.90
Shedding light on developmental gene regulation through the lens. Dev Growth Differ (2008) 0.78
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86
Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci (2005) 3.67
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A (2002) 3.25
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J Immunol (2005) 2.50
Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell (2009) 2.17
A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature (2013) 1.98
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91
Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci U S A (2012) 1.85
The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol (2005) 1.74
A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb. J Neurosci (2008) 1.69
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63
Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. Development (2006) 1.56
Generation of mice with a conditional null allele for Wntless. Genesis (2010) 1.55
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol (2008) 1.53
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 1.51
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development (2007) 1.47
Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa. Am J Hum Genet (2010) 1.41
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
CAMTAs: calmodulin-binding transcription activators from plants to human. FEBS Lett (2007) 1.40
Pax6: a multi-level regulator of ocular development. Prog Retin Eye Res (2012) 1.40
Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Dev Biol (2005) 1.38
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34
Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis. Sci Signal (2009) 1.34
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration. Trends Mol Med (2011) 1.34
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development (2007) 1.33
Bmp signaling is required for development of primary lens fiber cells. Development (2002) 1.33
Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol (2007) 1.33
Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development (2003) 1.32
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A (2011) 1.26
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proc Natl Acad Sci U S A (2011) 1.25
RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem (2011) 1.23
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development (2002) 1.23
Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation. Am J Respir Crit Care Med (2005) 1.22
Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development (2010) 1.22
Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development (2010) 1.15
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Dev Dyn (2005) 1.14
Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. Development (2004) 1.14
Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development (2007) 1.13
RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest (2011) 1.12
Pax6 is essential for lens fiber cell differentiation. Development (2009) 1.12
Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet (2013) 1.11
Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol (2011) 1.11
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin (2010) 1.10
β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology (2014) 1.09
Contributions by members of the TGFbeta superfamily to lens development. Int J Dev Biol (2004) 1.09
Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn (2008) 1.08
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development (2011) 1.07
Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet (2005) 1.06
Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci (2009) 1.06
The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Dev Biol (2011) 1.04
Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. Dev Biol (2011) 1.03
Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma. Invest Ophthalmol Vis Sci (2005) 1.02
Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. J Neurosci (2008) 1.01
The proliferation and expansion of retinal stem cells require functional Pax6. Dev Biol (2007) 0.98
Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol (2006) 0.98
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development (2013) 0.95
Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res (2013) 0.95
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proc Natl Acad Sci U S A (2011) 0.94
Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol (2009) 0.93
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome (2004) 0.92
Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. Hum Mol Genet (2013) 0.92
Lack of centrioles and primary cilia in STIL(-/-) mouse embryos. Cell Cycle (2014) 0.91
Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer. Exp Biol Med (Maywood) (2013) 0.91
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood (2013) 0.90
Eye formation in the absence of retina. Dev Biol (2008) 0.90
RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS One (2012) 0.89
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development (2013) 0.89
Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nat Neurosci (2013) 0.88
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88
Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development (2011) 0.88
RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Front Mol Neurosci (2012) 0.88
Iris development in vertebrates; genetic and molecular considerations. Brain Res (2007) 0.88
Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J Biol Chem (2009) 0.87
PAX6 maintains β cell identity by repressing genes of alternative islet cell types. J Clin Invest (2016) 0.86
Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. J Neurosci (2012) 0.85
Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma. Hum Mol Genet (2010) 0.84
The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone. PLoS One (2012) 0.84
Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells. PLoS One (2013) 0.84
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp Neurol (2009) 0.83
CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesis. PLoS One (2012) 0.83
Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. RNA (2007) 0.82
Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation. G3 (Bethesda) (2013) 0.82
Which FGF ligands are involved in lens induction? Dev Biol (2009) 0.81
Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina. J Comp Neurol (2007) 0.80
RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (2013) 0.80
In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice. Cereb Cortex (2009) 0.80
Length of day during early gestation as a predictor of risk for severe retinopathy of prematurity. Ophthalmology (2013) 0.79
Generation of an Rx-tTA: TetOp-Cre knock-in mouse line for doxycycline regulated Cre activity in the Rx expression domain. PLoS One (2012) 0.76
The retinal pigmented epithelium - from basic developmental biology research to translational approaches. Int J Dev Biol (2017) 0.75
Digesta retention patterns of solute and different-sized particles in camelids compared with ruminants and other foregut fermenters. J Comp Physiol B (2015) 0.75