Published in J Biol Chem on August 11, 2009
Vertebrate protein glycosylation: diversity, synthesis and function. Nat Rev Mol Cell Biol (2012) 2.83
A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem (2009) 2.49
Golgi glycosylation. Cold Spring Harb Perspect Biol (2011) 1.35
Function of the CysD domain of the gel-forming MUC2 mucin. Biochem J (2011) 1.16
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol (2010) 1.05
Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function. Cell Mol Life Sci (2011) 1.02
Whole exome sequence analysis of Peters anomaly. Hum Genet (2014) 0.96
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics. PLoS Pathog (2016) 0.91
Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism. Curr Biol (2014) 0.91
Novel roles for O-linked glycans in protein folding. Glycoconj J (2014) 0.86
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Mol Biol Cell (2016) 0.78
Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proc Natl Acad Sci U S A (2017) 0.78
In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family. PLoS One (2013) 0.77
Effects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma. PLoS One (2017) 0.75
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype. Mech Ageing Dev (2017) 0.75
Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. PLoS One (2017) 0.75
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature (2005) 5.71
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature (2005) 4.24
The ADAMTS metalloproteinases. Biochem J (2005) 3.95
Role of glycosylation in development. Annu Rev Biochem (2004) 3.67
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem (1999) 2.33
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol (2002) 2.28
A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family. Int J Biochem Cell Biol (2004) 2.06
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78
A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. Am J Hum Genet (2009) 1.63
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem (1999) 1.53
C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem (2000) 1.50
Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor. Mol Biol Cell (1998) 1.49
O-fucosylation is required for ADAMTS13 secretion. J Biol Chem (2007) 1.41
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. J Biol Chem (2007) 1.31
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
NetCGlyc 1.0: prediction of mammalian C-mannosylation sites. Glycobiology (2007) 1.30
Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J Biol Chem (2006) 1.28
Aggrecanase-mediated cartilage degradation. Curr Opin Pharmacol (2002) 1.28
New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us. Biochemistry (1994) 1.27
Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals. Mol Biol Cell (2001) 1.25
Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp. Mol Biol Cell (1998) 1.21
ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol (2007) 1.15
Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain. Glycobiology (2006) 1.15
Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J Biol Chem (2006) 1.13
Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. J Biol Chem (2006) 1.13
C-mannosylation and o-fucosylation of thrombospondin type 1 repeats. Mol Cell Proteomics (2002) 1.06
ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Matrix Biol (2003) 1.04
C-Mannosylation of human RNase 2 is an intracellular process performed by a variety of cultured cells. J Biol Chem (1997) 1.03
C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology (2004) 1.02
The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues. J Biol Chem (1999) 0.99
Recombinant human interleukin-12 is the second example of a C-mannosylated protein. Glycobiology (1999) 0.86
The WSAWS motif is C-hexosylated in a soluble form of the erythropoietin receptor. Biochemistry (2003) 0.81
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains. Science (2008) 2.28
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell (2009) 2.20
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation (2008) 2.12
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem (2003) 2.10
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol (2002) 1.80
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78
Matrix metalloproteinases: old dogs with new tricks. Genome Biol (2003) 1.59
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet (2007) 1.56
Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias. Am J Hum Genet (2011) 1.55
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem (2002) 1.51
O-fucosylation of notch occurs in the endoplasmic reticulum. J Biol Chem (2005) 1.43
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol (2005) 1.42
O-fucosylation is required for ADAMTS13 secretion. J Biol Chem (2007) 1.41
Notch signaling in normal and disease States: possible therapies related to glycosylation. Curr Mol Med (2007) 1.37
Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem (2005) 1.35
The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet (2008) 1.34
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. J Biol Chem (2007) 1.31
In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe. J Biol Chem (2007) 1.31
Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors. Curr Opin Struct Biol (2011) 1.29
Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J Biol Chem (2006) 1.28
ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem (2004) 1.26
ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem (2011) 1.25
Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns (2005) 1.25
Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol (2011) 1.23
Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem (2008) 1.23
Positional identification of variants of Adamts16 linked to inherited hypertension. Hum Mol Genet (2009) 1.21
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol (2008) 1.19
Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. J Biol Chem (2005) 1.18
O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. J Biol Chem (2011) 1.17
Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development (2006) 1.16
ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol (2007) 1.15
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science (2012) 1.15
Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J Biol Chem (2006) 1.13
Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. J Biol Chem (2006) 1.13
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development (2010) 1.12
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol (2010) 1.11
Cell-surface processing of pro-ADAMTS9 by furin. J Biol Chem (2006) 1.11
Role of glycosylation of Notch in development. Semin Cell Dev Biol (2010) 1.10
Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme. Hum Mutat (2008) 1.10
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum (2005) 1.10
Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem (2011) 1.09
Role of unusual O-glycans in intercellular signaling. Int J Biochem Cell Biol (2008) 1.08
Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. J Biol Chem (2004) 1.08
The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling. J Biol Chem (2007) 1.07
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis. J Biol Chem (2004) 1.07
Negative regulation of notch signaling by xylose. PLoS Genet (2013) 1.07
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol (2010) 1.07
The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol (2013) 1.06
A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development (2003) 1.06
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol (2010) 1.05
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A (2011) 1.05
ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Matrix Biol (2003) 1.04
Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function. Cell Mol Life Sci (2011) 1.02
Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide. J Biol Chem (2007) 1.01
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J Biol Chem (2009) 0.99
Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix. Glia (2013) 0.97
ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci (2012) 0.97
Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. Int J Cancer (2008) 0.96
Methods for analysis of O-linked modifications on epidermal growth factor-like and thrombospondin type 1 repeats. Methods Enzymol (2006) 0.96
The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family. Int J Biochem Cell Biol (2005) 0.95
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res (2010) 0.95
Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats. J Biol Chem (2012) 0.94
O-fucosylation of thrombospondin type 1 repeats. Methods Enzymol (2010) 0.94
Differential terminal fucosylation of N-linked glycans versus protein O-fucosylation in leukocyte adhesion deficiency type II (CDG IIc). J Biol Chem (2003) 0.93
Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem (2012) 0.92
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem (2011) 0.92
Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. Blood (2007) 0.91
CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet (2005) 0.90
Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process. Circ Res (2004) 0.89
Fucose is on the TRAIL of colon cancer. Gastroenterology (2009) 0.87
ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer. Int J Cancer (2007) 0.86
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. J Biol Chem (2009) 0.86
Novel roles for O-linked glycans in protein folding. Glycoconj J (2014) 0.86
Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome. Invest Ophthalmol Vis Sci (2013) 0.85
6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology (2012) 0.85
Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res (2011) 0.83
An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures. PLoS One (2010) 0.83
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis (2014) 0.82
Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome. Mol Cell Proteomics (2013) 0.81
Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants. J Biol Chem (2008) 0.80
Analyzing the posttranslational modification status of Notch using mass spectrometry. Methods Mol Biol (2014) 0.79
Isolation and purification of versican and analysis of versican proteolysis. Methods Mol Biol (2015) 0.78
Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. Mol Cancer Ther (2014) 0.78
Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae. J Biol Chem (2004) 0.78
Methods for analysis of unusual forms of O-glycosylation. Methods Mol Biol (2006) 0.76
Enzymatic analysis of the protein O-glycosyltransferase, Rumi, acting toward epidermal growth factor-like (EGF) repeats. Methods Mol Biol (2013) 0.75
A Quarter Century of Glycobiology. Glycobiology (2015) 0.75
Glycobiology: the study of the sweet life. Curr Opin Struct Biol (2011) 0.75
In situ hybridization for metalloproteinases and their inhibitors. Methods Mol Biol (2010) 0.75
Why we love glycobiology. Glycobiology (2016) 0.75