Published in J Biol Chem on January 03, 2003
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
The ADAMTS metalloproteinases. Biochem J (2005) 3.95
A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem (2009) 2.49
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell (2009) 2.20
Transcriptome-wide analysis of messenger RNA decay in normal and osteoarthritic human articular chondrocytes. Arthritis Rheumatol (2014) 2.09
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Res Ther (2006) 1.51
Extracellular matrix of the central nervous system: from neglect to challenge. Histochem Cell Biol (2008) 1.48
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther (2005) 1.37
The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet (2008) 1.34
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther (2005) 1.30
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study. PLoS One (2009) 1.29
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis Cartilage (2005) 1.24
Versican proteolysis mediates myocardial regression during outflow tract development. Dev Dyn (2007) 1.24
Versican degradation and vascular disease. Trends Cardiovasc Med (2006) 1.23
Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn (2006) 1.22
Positional identification of variants of Adamts16 linked to inherited hypertension. Hum Mol Genet (2009) 1.21
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21
BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion. J Neurooncol (2008) 1.17
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family. Genome Biol (2015) 1.16
Versican and the control of inflammation. Matrix Biol (2014) 1.13
The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-beta2. Br J Cancer (2007) 1.12
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development (2010) 1.12
Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. BMC Evol Biol (2005) 1.11
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol (2010) 1.11
Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem (2011) 1.09
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol (2010) 1.07
The role of ADAMTSs in arthritis. Protein Cell (2010) 1.03
ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. J Biol Chem (2009) 1.03
Proteoglycans in prostate cancer. Nat Rev Urol (2012) 0.99
TGF-β signaling in C. elegans. WormBook (2013) 0.99
Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. Arthritis Res Ther (2009) 0.98
Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. J Neuroinflammation (2012) 0.97
ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci (2012) 0.97
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells. Matrix Biol (2008) 0.96
ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis. BMB Rep (2013) 0.95
Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Hum Genomics (2009) 0.94
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. Ann Rheum Dis (2005) 0.93
Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem (2012) 0.92
Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans. EMBO J (2007) 0.91
The secreted AdamTS-A metalloprotease is required for collective cell migration. Development (2013) 0.88
Cell death-associated ADAMTS4 and versican degradation in vascular tissue. J Histochem Cytochem (2009) 0.87
Characterization and regulation of ADAMTS-16. Matrix Biol (2009) 0.87
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol (2013) 0.86
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. J Biol Chem (2009) 0.86
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage (2009) 0.83
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion? PLoS One (2011) 0.83
Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5. J Biol Chem (2014) 0.83
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis (2014) 0.82
C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization. Dev Biol (2011) 0.81
Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Mol Biol Cell (2012) 0.81
Versican: a novel modulator of hepatic fibrosis. Lab Invest (2016) 0.80
Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers (Basel) (2012) 0.80
A quantitative assay for aggrecanase activity. J Biomol Tech (2005) 0.79
Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease. Genetics (2012) 0.79
Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. J Neurosci (2014) 0.78
The periovulatory period in cattle: progesterone, prostaglandins, oxytocin and ADAMTS proteases. Anim Reprod (2009) 0.78
Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture. J Tissue Eng Regen Med (2010) 0.78
A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS). J Turk Ger Gynecol Assoc (2014) 0.77
Identification of a thrombin cleavage site and a short form of ADAMTS-18. Biochem Biophys Res Commun (2012) 0.76
Metabolism of cartilage proteoglycans in health and disease. Biomed Res Int (2014) 0.76
Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. PLoS One (2015) 0.76
Progesterone receptor and prostaglandins mediate luteinizing hormone-induced changes in messenger RNAs for ADAMTS proteases in theca cells of bovine periovulatory follicles. Mol Reprod Dev (2016) 0.75
Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep (2016) 0.75
The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system. Development (2017) 0.75
Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med (2006) 3.39
Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration. Arterioscler Thromb Vasc Biol (2007) 2.58
Hyaluronan-cell interactions in cancer and vascular disease. J Biol Chem (2001) 2.45
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell (2009) 2.20
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation (2008) 2.12
SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol (2003) 1.98
Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging. Arterioscler Thromb Vasc Biol (2010) 1.96
Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes (2007) 1.95
Enhanced extracellular matrix accumulation in restenosis of coronary arteries after stent deployment. J Am Coll Cardiol (2002) 1.92
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A (2012) 1.91
Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev (2009) 1.90
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways. Arterioscler Thromb Vasc Biol (2005) 1.87
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78
The ADAMTS proteases, extracellular matrix, and vascular disease: waking the sleeping giant(s)! Arterioscler Thromb Vasc Biol (2005) 1.76
Hyaluronan-dependent pericellular matrix. Adv Drug Deliv Rev (2007) 1.73
Intracellular hyaluronan: a new frontier for inflammation? Biochim Biophys Acta (2004) 1.64
Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice. Circulation (2004) 1.61
Matrix metalloproteinases: old dogs with new tricks. Genome Biol (2003) 1.59
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet (2007) 1.56
Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias. Am J Hum Genet (2011) 1.55
Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans. Cardiovasc Res (2008) 1.44
Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol (2005) 1.43
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol (2005) 1.42
Triglyceride-rich lipoproteins from subjects with type 2 diabetes do not demonstrate increased binding to biglycan, a vascular proteoglycan. J Clin Endocrinol Metab (2002) 1.38
Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells. J Immunol (2007) 1.38
The regulated synthesis of versican, decorin, and biglycan: extracellular matrix proteoglycans that influence cellular phenotype. Crit Rev Eukaryot Gene Expr (2004) 1.36
The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet (2008) 1.34
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
Extracellular matrix changes in stented human coronary arteries. Circulation (2004) 1.32
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. J Biol Chem (2001) 1.32
Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol (2002) 1.31
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. J Biol Chem (2007) 1.31
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading. Glycobiology (2004) 1.30
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol (2009) 1.28
Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. J Cell Physiol (2002) 1.27
ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem (2004) 1.26
Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns (2005) 1.25
ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem (2011) 1.25
Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury. Circ Res (2005) 1.24
Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol (2010) 1.23
Versican degradation and vascular disease. Trends Cardiovasc Med (2006) 1.23
Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol (2011) 1.23
Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. Respir Res (2008) 1.22
Positional identification of variants of Adamts16 linked to inherited hypertension. Hum Mol Genet (2009) 1.21
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients. Am J Pathol (2004) 1.21
Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells. J Leukoc Biol (2009) 1.20
Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol (2008) 1.19
Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts. Am J Respir Cell Mol Biol (2004) 1.18
Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice. J Cell Sci (2002) 1.17
ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors. Proc Natl Acad Sci U S A (2011) 1.17
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides. FEBS J (2009) 1.17
Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue. Am J Respir Cell Mol Biol (2003) 1.17
Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development (2006) 1.16
ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol (2007) 1.15
Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation. Circ Res (2008) 1.15
Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration. Matrix Biol (2011) 1.15
A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases. J Vasc Res (2002) 1.14
Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion. J Cell Physiol (2006) 1.13
Organization of hyaluronan and versican in the extracellular matrix of human fibroblasts treated with the viral mimetic poly I:C. J Histochem Cytochem (2009) 1.13
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development (2010) 1.12
Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-beta1 exhibit increased binding to LDLs. Arterioscler Thromb Vasc Biol (2002) 1.11
Cell-surface processing of pro-ADAMTS9 by furin. J Biol Chem (2006) 1.11
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol (2010) 1.11
Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion. Am J Respir Cell Mol Biol (2009) 1.10
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum (2005) 1.10
Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme. Hum Mutat (2008) 1.10
Matricellular hevin regulates decorin production and collagen assembly. J Biol Chem (2006) 1.09
Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem (2011) 1.09
Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. J Biol Chem (2004) 1.08
Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arterioscler Thromb Vasc Biol (2011) 1.08
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis Rheum (2010) 1.08
Intracellular hyaluronan in arterial smooth muscle cells: association with microtubules, RHAMM, and the mitotic spindle. J Histochem Cytochem (2004) 1.07
Developing vasculature and stroma in engineered human myocardium. Tissue Eng Part A (2011) 1.07
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis. J Biol Chem (2004) 1.07
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol (2010) 1.07
A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development (2003) 1.06
The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol (2013) 1.06
Lung lining fluid glutathione attenuates IL-13-induced asthma. Am J Respir Cell Mol Biol (2007) 1.06
Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection. Anat Rec (Hoboken) (2010) 1.06
Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. J Biol Chem (2009) 1.06
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. J Histochem Cytochem (2009) 1.05
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway. J Biol Chem (2013) 1.05
The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem (2010) 1.05
Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay. J Biol Chem (2005) 1.04
ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Matrix Biol (2003) 1.04
Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket. J Biol Chem (2003) 1.04