Published in J Biol Chem on September 04, 2009
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 2.74
Overview of the matrisome--an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol (2012) 2.26
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell (2009) 2.20
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma. JAMA Oncol (2015) 1.49
Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One (2015) 1.41
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36
Matrix-dependent perturbation of TGFβ signaling and disease. FEBS Lett (2012) 1.31
Fucosylation and gastrointestinal cancer. World J Hepatol (2010) 1.25
ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem (2011) 1.25
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet (2011) 1.19
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family. Genome Biol (2015) 1.16
Pathophysiology of the brain extracellular matrix: a new target for remyelination. Nat Rev Neurosci (2013) 1.15
Host matrix modulation by tumor exosomes promotes motility and invasiveness. Neoplasia (2013) 1.14
Versican and the control of inflammation. Matrix Biol (2014) 1.13
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development (2010) 1.12
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol (2010) 1.11
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10
Extracellular matrix as an inductive scaffold for functional tissue reconstruction. Transl Res (2013) 1.09
TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). J Cell Physiol (2011) 1.09
Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration. Cell Metab (2014) 1.08
Structure-function and regulation of ADAMTS-13 protease. J Thromb Haemost (2013) 1.06
The role of ADAMTSs in arthritis. Protein Cell (2010) 1.03
Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function. Cell Mol Life Sci (2011) 1.02
Allosteric activation of ADAMTS13 by von Willebrand factor. Proc Natl Acad Sci U S A (2014) 1.02
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Versican and the regulation of cell phenotype in disease. Biochim Biophys Acta (2014) 0.99
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage. FASEB J (2012) 0.98
Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. Eur Spine J (2013) 0.98
Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases. J Biol Chem (2012) 0.97
ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci (2012) 0.97
Molecular mechanisms of thoracic aortic dissection. J Surg Res (2013) 0.96
Biological Significance of Local TGF-β Activation in Liver Diseases. Front Physiol (2012) 0.95
Contribution of the latent transforming growth factor-β binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome. Mol Vis (2013) 0.95
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res (2010) 0.95
The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. Am J Pathol (2011) 0.95
Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet (2015) 0.95
Hen uterine gene expression profiling during eggshell formation reveals putative proteins involved in the supply of minerals or in the shell mineralization process. BMC Genomics (2014) 0.92
Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem (2012) 0.92
Architecture and function of metallopeptidase catalytic domains. Protein Sci (2014) 0.92
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis. J Histochem Cytochem (2011) 0.92
Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology (2011) 0.92
ADAMTS proteins as modulators of microfibril formation and function. Matrix Biol (2015) 0.90
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase. J Biol Chem (2013) 0.88
C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains. Nature (2014) 0.87
Emerging functions of matricellular proteins. Cell Mol Life Sci (2011) 0.87
ADAMTS14 Gene Polymorphism and Environmental Risk in the Development of Oral Cancer. PLoS One (2016) 0.87
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol (2013) 0.86
Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan. J Cell Biochem (2010) 0.86
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. J Biol Chem (2009) 0.86
ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro. J Histochem Cytochem (2013) 0.85
Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. J Biol Chem (2013) 0.85
Gene expression profiling reveals new potential players of gonad differentiation in the chicken embryo. PLoS One (2011) 0.84
Non-housekeeping genes expressed in human trabecular meshwork cell cultures. Mol Vis (2012) 0.84
Differential expression of extracellular matrix components in the Fallopian tubes throughout the menstrual cycle. Reprod Biol Endocrinol (2012) 0.84
Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice. Cancer Lett (2012) 0.84
Molecular pathogenesis and management strategies of ectopia lentis. Eye (Lond) (2014) 0.83
Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest Ophthalmol Vis Sci (2013) 0.83
An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures. PLoS One (2010) 0.83
ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem (2012) 0.83
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis (2014) 0.82
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis (2015) 0.81
Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides. Arthritis Rheum (2012) 0.81
Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn (2011) 0.81
A Panel of Genetic Polymorphism for the Prediction of Prognosis in Patients with Early Stage Non-Small Cell Lung Cancer after Surgical Resection. PLoS One (2015) 0.81
Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids. Arterioscler Thromb Vasc Biol (2012) 0.81
New negative feedback regulators of Egfr signaling in Drosophila. Genetics (2012) 0.81
Matrix Metalloproteinases in Non-Neoplastic Disorders. Int J Mol Sci (2016) 0.81
Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators. Int J Exp Pathol (2010) 0.80
Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes. J Cell Biochem (2015) 0.80
Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers (Basel) (2012) 0.80
Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils. J Biol Chem (2013) 0.79
Variability in melanoma metalloproteinase expression profiling. J Biomol Tech (2010) 0.79
Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. J Neurosci (2014) 0.78
Angiogenesis and Proteinases: Influence on Vascular Morphogenesis, Stabilization and Regression. Drug Discov Today Dis Models (2011) 0.78
ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- α and NF- κ B P65. Mediators Inflamm (2015) 0.78
The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish. BMC Evol Biol (2015) 0.77
Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biol Open (2016) 0.77
ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep (2015) 0.77
A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche. Am J Pathol (2015) 0.77
The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans. Genetics (2013) 0.77
ADAMTS13 and von Willebrand factor interactions. Curr Opin Hematol (2015) 0.77
An anxiogenic drug, FG 7142, induced an increase in mRNA of Btg2 and Adamts1 in the hippocampus of adult mice. Behav Brain Funct (2012) 0.76
ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer. Oncotarget (2016) 0.76
Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1. Oncotarget (2014) 0.76
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview. Toxins (Basel) (2016) 0.76
Identification of a thrombin cleavage site and a short form of ADAMTS-18. Biochem Biophys Res Commun (2012) 0.76
Autosomal recessive bilateral frontal polymicrogyria with ectopia lentis and chorioretinal dystrophy. Ann Indian Acad Neurol (2013) 0.75
Chondrodysplasias and TGFβ signaling. Bonekey Rep (2015) 0.75
Progesterone acts via the progesterone receptor to induce adamts proteases in ovarian cancer cells. J Ovarian Res (2016) 0.75
Matricellular signal transduction involving calmodulin in the social amoebozoan dictyostelium. Genes (Basel) (2013) 0.75
Inhibitory Synapses Get Madd for Neuroligin. Neuron (2015) 0.75
Pathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's Disease. Aging Dis (2016) 0.75
Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr (2016) 0.75
Provisional matrix: A role for versican and hyaluronan. Matrix Biol (2016) 0.75
Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant. BMC Musculoskelet Disord (2016) 0.75
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature (2001) 6.95
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature (2005) 5.71
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature (2005) 4.24
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem (2001) 3.02
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem (2001) 2.58
The molecular genetics of Marfan syndrome and related disorders. J Med Genet (2006) 2.45
In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome. J Med Genet (2003) 2.26
ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome. Am J Hum Genet (2004) 2.22
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell (2008) 2.13
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem (2003) 2.10
Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem (1997) 2.01
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. Am J Hum Genet (1999) 1.98
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem (2003) 1.87
Essential role of the disintegrin-like domain in ADAMTS13 function. Blood (2009) 1.86
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem (2003) 1.84
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78
The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. Dev Biol (1999) 1.70
ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem (2003) 1.65
A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. Am J Hum Genet (2009) 1.63
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. EMBO J (2006) 1.59
Binding of ADAMTS13 to von Willebrand factor. J Biol Chem (2005) 1.58
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. Nature (1999) 1.54
A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans. Curr Biol (2004) 1.53
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem (1999) 1.53
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. J Clin Invest (2000) 1.53
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem (2000) 1.50
C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem (2000) 1.50
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene (2006) 1.49
Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. J Biol Chem (2001) 1.49
GON-1 and fibulin have antagonistic roles in control of organ shape. Curr Biol (2004) 1.45
ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem (2005) 1.45
Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. J Biol Chem (2001) 1.45
O-fucosylation is required for ADAMTS13 secretion. J Biol Chem (2007) 1.41
ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. J Biol Chem (1998) 1.40
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. J Biol Chem (2002) 1.39
Cleavage of the ADAMTS13 propeptide is not required for protease activity. J Biol Chem (2003) 1.39
Fine tuning of growth factor signals depends on fibrillin microfibril networks. Birth Defects Res C Embryo Today (2004) 1.37
Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod (2003) 1.35
The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet (2008) 1.34
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem (2004) 1.33
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. J Biol Chem (2007) 1.31
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem (2005) 1.28
ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem (2004) 1.26
Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns (2005) 1.25
Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn (2006) 1.22
A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans. Science (2000) 1.21
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod (2005) 1.20
Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms. J Biol Chem (2000) 1.19
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. J Mol Biol (2007) 1.18
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen. Biochemistry (1978) 1.18
Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development (2006) 1.16
Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Development (2000) 1.14
Cell-surface processing of pro-ADAMTS9 by furin. J Biol Chem (2006) 1.11
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res (2009) 1.10
ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. J Mol Endocrinol (2005) 1.08
Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. J Biol Chem (2004) 1.08
Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Dev Biol (2006) 1.07
A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development (2003) 1.06
Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V. J Biol Chem (2005) 1.06
Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. J Biol Chem (2009) 1.06
A review of the ADAMTS family, pharmaceutical targets of the future. Curr Pharm Des (2009) 1.05
Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene (2006) 1.05
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. J Biol Chem (2004) 1.02
Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide. J Biol Chem (2007) 1.01
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int J Biochem Cell Biol (2008) 1.01
Sea urchin metalloproteases: a genomic survey of the BMP-1/tolloid-like, MMP and ADAM families. Dev Biol (2006) 0.98
The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family. Int J Biochem Cell Biol (2005) 0.95
C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV. Development (2009) 0.94
Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans. EMBO J (2007) 0.91
Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis. Nephrol Dial Transplant (2004) 0.90
MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans. Proc Natl Acad Sci U S A (2008) 0.85
Ehlers-Danlos type VII-C, or human dermatosparaxis. The offspring of a union between basic and clinical research. Arch Dermatol (1993) 0.85
Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity. Dev Biol (2006) 0.84
Stage-specific activation of MIG-17/ADAMTS controls cell migration in Caenorhabditis elegans. FEBS J (2008) 0.83