Published in Biochem Biophys Res Commun on August 31, 2010
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex. Development (2012) 1.65
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One (2012) 1.11
Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models. Transl Psychiatry (2012) 1.00
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton. Front Cell Neurosci (2014) 0.99
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A (2014) 0.96
In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist (2011) 0.94
Synapse-specific contributions in the cortical pathology of schizophrenia. Neurobiol Dis (2013) 0.91
DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders. Front Psychiatry (2012) 0.90
Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain. Front Mol Neurosci (2011) 0.84
Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience (2011) 0.84
DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1. Mol Psychiatry (2016) 0.79
Neuronal migration abnormalities and its possible implications for schizophrenia. Front Neurosci (2015) 0.78
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psychiatry (2016) 0.78
Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels. Front Synaptic Neurosci (2016) 0.77
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci (2014) 0.76
Half-life of DISC1 protein and its pathological significance under hypoxia stress. Neurosci Res (2015) 0.75
Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse. PLoS One (2017) 0.75
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Cell migration in the forebrain. Annu Rev Neurosci (2003) 4.59
Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortex. Neuroscience (2001) 4.45
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol (2005) 3.89
Behavioral phenotypes of Disc1 missense mutations in mice. Neuron (2007) 3.68
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci (2010) 2.90
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev (2006) 2.89
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron (2009) 2.72
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol (2005) 2.61
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci (2009) 2.55
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron (2010) 2.53
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci U S A (2008) 2.37
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A (2006) 2.32
Multipolar migration: the third mode of radial neuronal migration in the developing cerebral cortex. J Neurosci (2003) 2.32
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01
Understanding the role of DISC1 in psychiatric disease and during normal development. J Neurosci (2009) 1.89
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84
A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry (2006) 1.82
DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci U S A (2009) 1.76
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry (2008) 1.51
New and improved tools for in utero electroporation studies of developing cerebral cortex. Cereb Cortex (2009) 1.44
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol Psychiatry (2007) 1.32
Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci (2010) 1.29
Disruption of hippocampal development in vivo by CR-50 mAb against reelin. Proc Natl Acad Sci U S A (1997) 1.24
Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics (2006) 1.15
Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. Schizophr Bull (2006) 1.12
Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet (2009) 0.97
Animal models for schizophrenia via in utero gene transfer: understanding roles for genetic susceptibility factors in brain development. Prog Brain Res (2009) 0.92
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol (2005) 3.89
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34
Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31
Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A (2007) 3.02
Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01
The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development (2004) 2.94
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci (2010) 2.90
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci (2009) 2.55
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron (2010) 2.53
KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature (2012) 2.47
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol (2002) 2.40
Multipolar migration: the third mode of radial neuronal migration in the developing cerebral cortex. J Neurosci (2003) 2.32
Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry (2010) 2.11
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res (2003) 2.08
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07
The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood (2010) 2.05
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (2013) 2.04
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98
PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97
Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking. Neuron (2010) 1.95
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry (2006) 1.82
Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet (2006) 1.82
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80
Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80
Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem (2005) 1.80
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev (2002) 1.56
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation (2004) 1.53
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature (2011) 1.53
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry (2008) 1.51
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
Key regulators in neuronal polarity. Neuron (2005) 1.46
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39
COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream. J Neurosci (2008) 1.38
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38
Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37
Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure (2006) 1.37
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet (2011) 1.36
Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol (2009) 1.35
Signaling networks in neuronal polarization. J Neurosci (2006) 1.35
Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep (2006) 1.32
The impact of HLA antibodies on engraftment of unrelated cord blood transplants. Transfusion (2008) 1.30
Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun (2005) 1.29
Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis. J Neurosci (2008) 1.28
AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem (2003) 1.28
Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27
DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci (2007) 1.27
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension (2002) 1.24
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci (2007) 1.24
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Mol Biol Cell (2007) 1.23
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet (2008) 1.23
Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci (2004) 1.21
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20
Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A (2010) 1.18
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17
The caudal migratory stream: a novel migratory stream of interneurons derived from the caudal ganglionic eminence in the developing mouse forebrain. J Neurosci (2005) 1.17
Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell (2004) 1.17