Published in J Neurosci on January 03, 2007
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci (2009) 2.55
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A (2008) 1.90
Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci (2008) 1.67
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron (2011) 1.67
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry (2010) 1.28
DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev (2010) 1.24
Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron (2011) 1.19
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia. Biol Psychiatry (2008) 1.10
Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Mol Biol Cell (2010) 1.07
Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. PLoS One (2011) 1.05
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1). J Neurochem (2011) 0.97
A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport. Mol Neurodegener (2010) 0.97
Gene expression in the etiology of schizophrenia. Schizophr Bull (2008) 0.93
Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample. Schizophr Res (2010) 0.92
DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders. Front Psychiatry (2012) 0.90
DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder? PLoS One (2011) 0.86
Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice. Psychopharmacology (Berl) (2009) 0.84
Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. FASEB J (2011) 0.83
Impaired fast-spiking interneuron function in a genetic mouse model of depression. Elife (2015) 0.82
Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. Behav Brain Funct (2011) 0.82
DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity. J Physiol (2016) 0.79
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. Am J Pathol (2009) 0.79
Flexible search for single-axon morphology during neuronal spontaneous polarization. PLoS One (2011) 0.78
Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels. Front Synaptic Neurosci (2016) 0.77
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations. J Biol Chem (2017) 0.76
DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats. Front Syst Neurosci (2015) 0.76
Partial rodent genetic models for bipolar disorder. Curr Top Behav Neurosci (2011) 0.76
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. EMBO Rep (2016) 0.75
Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. Neurobiol Dis (2017) 0.75
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
Identification of a factor that links apoptotic cells to phagocytes. Nature (2002) 6.76
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31
Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol (2005) 2.57
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol (2002) 2.40
The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat Cell Biol (2002) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol (2004) 2.14
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature (2002) 2.08
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res (2003) 2.08
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98
PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84
Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80
Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem (2005) 1.80
Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev (2002) 1.56
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation (2004) 1.53
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. Oncogene (2002) 1.48
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47
Key regulators in neuronal polarity. Neuron (2005) 1.46
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37
Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure (2006) 1.37
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet (2011) 1.36
Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol (2009) 1.35
Signaling networks in neuronal polarization. J Neurosci (2006) 1.35
Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep (2006) 1.32
Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun (2005) 1.29
AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem (2003) 1.28
Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension (2002) 1.24
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci (2007) 1.24
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Mol Biol Cell (2007) 1.23
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet (2008) 1.23
Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci (2004) 1.21
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17
Enzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases. Biochem J (2004) 1.17
Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell (2004) 1.17
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J Cardiovasc Pharmacol (2006) 1.16
Axon specification in hippocampal neurons. Neurosci Res (2002) 1.16
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem (2009) 1.14
Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin. J Cell Biol (2012) 1.12