Published in J Neurosci on September 16, 2009
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Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell (2010) 4.16
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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev (2008) 2.76
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Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci (2011) 1.82
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Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res (2007) 1.64
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab (2008) 1.63
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature (2009) 1.62
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
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T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med (2004) 1.55
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol (2009) 1.55
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem (2007) 1.53
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Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest (2008) 1.50
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab (2010) 1.49
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab (2008) 1.49
Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology (2007) 1.48
Hormone and glucose signalling in POMC and AgRP neurons. J Physiol (2009) 1.48
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Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab (2013) 1.45
Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic Acids Res (2005) 1.44
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab (2007) 1.39
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Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metab (2009) 1.36
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab (2010) 1.36
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J (2009) 1.36
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Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes (2005) 1.27
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