Published in Obesity (Silver Spring) on August 01, 2006
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab (2009) 2.69
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85
Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol (2008) 1.84
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci (2011) 1.82
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J Clin Invest (2009) 1.77
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest (2010) 1.66
Leptin regulation of neuronal excitability and cognitive function. Curr Opin Pharmacol (2007) 1.64
Retracted Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab (2011) 1.60
Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nat Commun (2015) 1.57
Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) (2008) 1.48
Joint morphogenetic cells in the adult mammalian synovium. Nat Commun (2017) 1.46
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res (2011) 1.46
Leptin in human physiology and therapeutics. Front Neuroendocrinol (2010) 1.46
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab (2014) 1.42
Molecular and neural mediators of leptin action. Physiol Behav (2008) 1.40
Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest (2010) 1.30
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes (2010) 1.29
Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice. Am J Physiol Regul Integr Comp Physiol (2008) 1.28
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology (Berl) (2009) 1.27
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol (2007) 1.25
Energy regulatory signals and food reward. Pharmacol Biochem Behav (2010) 1.25
Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. J Biol Chem (2010) 1.23
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin. Proc Natl Acad Sci U S A (2010) 1.20
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology (2009) 1.19
Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol Metab (2014) 1.11
Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocr Rev (2013) 1.10
Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am J Physiol Endocrinol Metab (2013) 1.00
Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A (2013) 0.97
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab (2012) 0.95
Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology (2012) 0.94
Leptin in hepatocellular carcinoma. World J Gastroenterol (2010) 0.93
TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons. Mol Metab (2015) 0.93
Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. J Neurochem (2010) 0.93
Innervation of skeletal muscle by leptin receptor-containing neurons. Brain Res (2010) 0.90
Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway. Am J Physiol Regul Integr Comp Physiol (2009) 0.90
The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency. J Obes (2012) 0.89
Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes (2010) 0.88
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus. Physiol Behav (2011) 0.88
Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci (2016) 0.87
Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates. Transl Psychiatry (2014) 0.87
Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism. Endocrinology (2015) 0.85
Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system. Front Psychol (2014) 0.84
Developmental switch of leptin signaling in arcuate nucleus neurons. J Neurosci (2014) 0.84
Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus. J Physiol (2011) 0.84
Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. J Endocrinol (2011) 0.83
Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab (2014) 0.83
Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms. Biol Psychiatry (2015) 0.82
Leptin acts independently of food intake to modulate gut microbial composition in male mice. Endocrinology (2014) 0.82
Taste responsiveness to sweeteners is resistant to elevations in plasma leptin. Chem Senses (2015) 0.81
Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab (2012) 0.80
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells. Int J Mol Sci (2015) 0.80
Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci (2016) 0.80
Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. J Physiol (2016) 0.79
Anorexia nervosa: a unified neurological perspective. Int J Med Sci (2011) 0.79
Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. Am J Physiol Endocrinol Metab (2014) 0.78
Regulation of leptin receptor-expressing neurons in the brainstem by TRPV1. Physiol Rep (2014) 0.78
Energy Balance, Myostatin, and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone. PPAR Res (2007) 0.78
Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am (2012) 0.78
Goldfish Leptin-AI and Leptin-AII: Function and Central Mechanism in Feeding Control. Int J Mol Sci (2016) 0.77
Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus. Peptides (2015) 0.75
Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab (2017) 0.75
The glucoregulatory actions of leptin. Mol Metab (2017) 0.75
Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab (2009) 5.32
STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 5.27
Mechanisms of leptin action and leptin resistance. Annu Rev Physiol (2008) 4.72
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
TXNIP regulates peripheral glucose metabolism in humans. PLoS Med (2007) 3.27
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes (2003) 2.90
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab (2009) 2.69
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2005) 2.13
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol (2007) 1.96
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83
Influenza pandemic preparedness action plan for the United States: 2002 update. Clin Infect Dis (2002) 1.82
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci (2011) 1.82
FGF21 is an endocrine signal of protein restriction. J Clin Invest (2014) 1.76
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci (2007) 1.66
The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2009) 1.64
The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab (2003) 1.64
Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation (2007) 1.62
Retracted Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab (2011) 1.60
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes (2004) 1.59
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem (2002) 1.57
Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study. Eur Heart J (2008) 1.55
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem (2007) 1.53
Pseudoresistant hypertension attributed to white-coat effect. Hypertension (2012) 1.50
The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2007) 1.49
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab (2005) 1.48
Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology (2007) 1.48
The lateral hypothalamus as integrator of metabolic and environmental needs: from electrical self-stimulation to opto-genetics. Physiol Behav (2011) 1.47
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res (2011) 1.46
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab (2013) 1.45
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol (2004) 1.43
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43
The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2006) 1.42
Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure. J Hypertens (2002) 1.41
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A (2003) 1.41
Molecular and neural mediators of leptin action. Physiol Behav (2008) 1.40
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab (2007) 1.39
The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol (2011) 1.38
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A (2008) 1.34
Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci (2009) 1.32
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes (2010) 1.29
Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs. J Infect Dis (2003) 1.28
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci (2013) 1.26
Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes (2009) 1.25
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol (2007) 1.25
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol (2006) 1.23
Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med (2012) 1.22
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol (2004) 1.22
Inflammation-induced lethargy is mediated by suppression of orexin neuron activity. J Neurosci (2011) 1.22
Critical roles for the TSC-mTOR pathway in β-cell function. Am J Physiol Endocrinol Metab (2009) 1.20
The 2004 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2004) 1.20
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology (2009) 1.19
Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci (2012) 1.18
A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol (2010) 1.17
Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci (2010) 1.17
GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents. Am J Physiol Regul Integr Comp Physiol (2014) 1.16
Modulation of the mesolimbic dopamine system by leptin. Brain Res (2010) 1.14
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci (2009) 1.13
Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes (2005) 1.10
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology (2011) 1.10
Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab (2004) 1.08
Intussusception, rotavirus, and oral vaccines: summary of a workshop. Pediatrics (2002) 1.08
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol (2006) 1.08
Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity. PLoS One (2008) 1.07
The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2010) 1.07
Primary prevention drug therapy: can it meet patients' requirements for reduced risk? Med Decis Making (2002) 1.06
Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology (2012) 1.05
The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2008) 1.05
Neural and metabolic regulation of macronutrient intake and selection. Proc Nutr Soc (2012) 1.04
Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab (2011) 1.04
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab (2012) 1.02
The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Can J Cardiol (2002) 1.02
Early-life exposure to testosterone programs the hypothalamic melanocortin system. Endocrinology (2011) 1.01