Published in PLoS One on September 11, 2009
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell (2010) 2.09
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor. Nat Struct Mol Biol (2012) 1.81
Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev (2010) 1.67
Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis. Nat Immunol (2015) 1.42
Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci (2010) 1.16
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs. Nat Neurosci (2012) 1.02
Expanding the role of Drosha to the regulation of viral gene expression. Proc Natl Acad Sci U S A (2011) 0.99
Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J (2015) 0.95
Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers. PLoS One (2012) 0.95
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO J (2015) 0.91
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer. Open Biol (2013) 0.91
MicroRNA Machinery Genes as Novel Biomarkers for Cancer. Front Oncol (2014) 0.88
Efficiency and specificity in microRNA biogenesis. Nat Struct Mol Biol (2012) 0.85
cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression. J Virol (2011) 0.83
Drosha promotes splicing of a pre-microRNA-like alternative exon. PLoS Genet (2014) 0.82
DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One (2013) 0.81
Global identification of target recognition and cleavage by the Microprocessor in human ES cells. Nucleic Acids Res (2014) 0.81
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. Cell Death Differ (2014) 0.79
Human RNAi pathway: crosstalk with organelles and cells. Funct Integr Genomics (2013) 0.77
Intron cleavage affects processing of alternatively spliced transcripts. RNA (2011) 0.77
DGCR8 is essential for tumor progression following PTEN loss in the prostate. EMBO Rep (2015) 0.76
Drosha mediates destabilization of Lin28 mRNA targets. Cell Cycle (2012) 0.76
MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression. EMBO Rep (2017) 0.75
The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis. Virology (2017) 0.75
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49
The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res (2007) 23.13
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007) 15.46
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11
SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Post-transcriptional processing generates a diversity of 5'-modified long and short RNAs. Nature (2009) 6.88
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
Identification and classification of conserved RNA secondary structures in the human genome. PLoS Comput Biol (2006) 6.73
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol (2004) 6.56
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep (2005) 5.82
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res (2008) 5.16
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88
Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol (2006) 3.30
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol (2009) 2.59
Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67
Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA (2009) 1.59
CoGemiR: a comparative genomics microRNA database. BMC Genomics (2008) 0.97
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol (2009) 5.14
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature (2010) 5.10
Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell (2007) 4.94
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol (2011) 4.06
Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54
Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells. Immunity (2011) 2.71
MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol (2010) 2.57
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients. Cancer Res (2010) 1.89
Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Res (2009) 1.69
Distinct requirements of microRNAs in NK cell activation, survival, and function. J Immunol (2010) 1.48
Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev (2011) 1.47
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol (2013) 1.39
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med (2010) 1.35
Small RNAs in early mammalian development: from gametes to gastrulation. Development (2011) 1.33
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev (2011) 1.16
From microRNAs to targets: pathway discovery in cell fate transitions. Curr Opin Genet Dev (2011) 1.15
MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation. Adv Exp Med Biol (2010) 1.05
miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. Cell Rep (2013) 0.99
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex. Mol Cell Neurosci (2012) 0.98
TRA-1/GLI controls development of somatic gonadal precursors in C. elegans. Development (2004) 0.97
MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol (2013) 0.95
Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J (2004) 0.95
Small RNAs in germline development. Curr Top Dev Biol (2013) 0.91
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res (2010) 0.90
Cell cycle regulation by microRNAs in stem cells. Results Probl Cell Differ (2011) 0.89
Sox1 marks an activated neural stem/progenitor cell in the hippocampus. Development (2012) 0.88
Watching reprogramming in real time. Nat Biotechnol (2009) 0.87
An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol (2012) 0.87
High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs. J Vis Exp (2011) 0.87
microRNA induced transdifferentiation. F1000 Biol Rep (2012) 0.86
Dgcr8 controls neural crest cells survival in cardiovascular development. Dev Biol (2011) 0.85
Efficiency and specificity in microRNA biogenesis. Nat Struct Mol Biol (2012) 0.85
DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One (2013) 0.81
CompMoby: comparative MobyDick for detection of cis-regulatory motifs. BMC Bioinformatics (2008) 0.80
Generation of induced pluripotent stem cells from the prairie vole. PLoS One (2012) 0.80
Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol (2013) 0.79
Regenerative medicine: short cut to cell replacement. Nature (2008) 0.77
On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell (2010) 0.75