Published in Science on February 21, 2008
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09
Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer (2010) 7.39
MicroRNAs and cancer: short RNAs go a long way. Cell (2009) 7.25
Control of the embryonic stem cell state. Cell (2011) 6.89
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
miRNAs in human cancer. J Pathol (2010) 6.02
Forcing cells to change lineages. Nature (2009) 5.99
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell (2010) 5.67
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2011) 5.12
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature (2010) 5.10
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell (2009) 4.54
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
On the road to reading the RNA-interference code. Nature (2009) 4.33
Small RNAs and their roles in plant development. Annu Rev Cell Dev Biol (2009) 4.32
MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol (2009) 4.26
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell (2009) 3.90
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle (2009) 3.68
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res (2009) 3.53
Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron (2009) 3.27
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
Alu element-mediated gene silencing. EMBO J (2008) 3.22
MicroRNAs in human cancer. Adv Exp Med Biol (2013) 3.19
mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol (2010) 3.15
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell (2010) 3.12
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J (2009) 3.11
Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet (2009) 3.09
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet (2009) 3.06
MicroRNA control of muscle development and disease. Curr Opin Cell Biol (2009) 3.04
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
microRNA involvement in human cancer. Carcinogenesis (2012) 2.98
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol (2011) 2.79
Frequency and fate of microRNA editing in human brain. Nucleic Acids Res (2008) 2.77
Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol (2010) 2.73
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
MicroRNA biogenesis pathways in cancer. Nat Rev Cancer (2015) 2.67
Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One (2010) 2.63
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. Genome Res (2008) 2.52
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
Pattern formation via small RNA mobility. Genes Dev (2009) 2.50
MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol (2014) 2.36
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes Dev (2008) 2.34
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells. RNA (2009) 2.30
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat Struct Mol Biol (2010) 2.30
The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proc Natl Acad Sci U S A (2009) 2.29
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res (2009) 2.27
Pluripotent stem cell lines. Genes Dev (2008) 2.25
Leukaemogenesis: more than mutant genes. Nat Rev Cancer (2010) 2.16
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics (2009) 2.15
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol (2009) 2.12
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
Proinflammatory role for let-7 microRNAS in experimental asthma. J Biol Chem (2010) 2.08
SNPs in human miRNA genes affect biogenesis and function. RNA (2009) 2.08
LIN28B promotes colon cancer progression and metastasis. Cancer Res (2011) 2.05
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science (2012) 2.03
Stem cell metabolism in tissue development and aging. Development (2013) 2.01
An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma (2009) 1.99
Phenotypic plasticity of adventitious rooting in Arabidopsis is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. Plant Cell (2009) 1.98
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet (2012) 1.96
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation. J Immunol (2009) 1.93
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Mol Cell (2012) 1.93
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Res (2009) 1.93
MicroRNA let-7: an emerging next-generation cancer therapeutic. Curr Oncol (2010) 1.90
Roles of small RNAs in tumor formation. Trends Mol Med (2010) 1.89
Cell-cell contact globally activates microRNA biogenesis. Proc Natl Acad Sci U S A (2009) 1.89
Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007) 15.46
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42
Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev (2006) 11.04
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
Human embryonic stem cells express a unique set of microRNAs. Dev Biol (2004) 8.87
Post-transcriptional regulation of microRNA expression. RNA (2006) 6.76
Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J (2006) 4.34
Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene (2006) 4.13
The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells (2004) 3.78
The expression profile of microRNAs in mouse embryos. Nucleic Acids Res (2006) 3.49
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev (2007) 3.46
Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules. RNA Biol (2007) 2.69
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell (2002) 5.71
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet (2010) 5.37
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Generation of human-induced pluripotent stem cells. Nat Protoc (2008) 4.85
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature (2003) 4.56
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37
Chromatin-modifying enzymes as modulators of reprogramming. Nature (2012) 4.22
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature (2009) 3.93
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science (2012) 3.74
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One (2011) 2.86
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
High-efficiency RNA interference in human embryonic stem cells. Stem Cells (2005) 2.76
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells (2009) 2.59
Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov (2011) 2.58
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells (2004) 2.37
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature (2012) 2.32
Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 2.28
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell (2008) 2.17
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell (2007) 2.14
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05
Stem cell metabolism in tissue development and aging. Development (2013) 2.01
The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell (2012) 1.96
Therapeutic potential of embryonic stem cells. Blood Rev (2005) 1.96
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell (2012) 1.89
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood (2010) 1.88
Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng (2002) 1.85
Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol (2004) 1.83
Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev (2010) 1.77
Altered nuclear transfer in stem-cell research - a flawed proposal. N Engl J Med (2004) 1.77
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood (2002) 1.72
Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients. Ann Neurol (2011) 1.72
Reprogramming cellular identity for regenerative medicine. Cell (2012) 1.71
Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes. Blood (2008) 1.71
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell (2013) 1.68
Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67