Published in RNA on April 21, 2009
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
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Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
MicroRNA biogenesis pathways in cancer. Nat Rev Cancer (2015) 2.67
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs. Nucleic Acids Res (2010) 2.08
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor. Nat Struct Mol Biol (2012) 1.81
Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol (2010) 1.71
Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Res (2012) 1.63
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends Cell Biol (2009) 1.33
Mirtrons: microRNA biogenesis via splicing. Biochimie (2011) 1.24
MicroRNAs in psychiatric and neurodevelopmental disorders. Brain Res (2010) 1.22
Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8. PLoS One (2009) 1.18
The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders. Int J Dev Neurosci (2010) 1.16
Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci (2010) 1.16
Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat Struct Mol Biol (2011) 1.16
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA (2010) 1.15
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA (2013) 1.15
Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep (2013) 1.15
Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site. Proc Natl Acad Sci U S A (2013) 1.12
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour. Nat Commun (2014) 1.08
Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing. Nucleic Acids Res (2011) 1.06
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. Carcinogenesis (2010) 1.01
Drosha regulates gene expression independently of RNA cleavage function. Cell Rep (2013) 0.96
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. RNA (2011) 0.96
Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell Mol Life Sci (2013) 0.95
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells. Neoplasia (2012) 0.91
Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility. PLoS One (2014) 0.91
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer. Open Biol (2013) 0.91
Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci U S A (2014) 0.89
MicroRNAs and synaptic plasticity--a mutual relationship. Philos Trans R Soc Lond B Biol Sci (2014) 0.89
Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8. Protein Sci (2012) 0.88
MicroRNA Machinery Genes as Novel Biomarkers for Cancer. Front Oncol (2014) 0.88
Efficiency and specificity in microRNA biogenesis. Nat Struct Mol Biol (2012) 0.85
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs. Mol Cell (2015) 0.84
Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance. Front Genet (2013) 0.82
Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins. Immunol Rev (2013) 0.80
Alternative splicing affects the subcellular localization of Drosha. Nucleic Acids Res (2016) 0.79
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways. Trends Genet (2014) 0.79
The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease. Biomolecules (2015) 0.78
Intron cleavage affects processing of alternatively spliced transcripts. RNA (2011) 0.77
Human RNAi pathway: crosstalk with organelles and cells. Funct Integr Genomics (2013) 0.77
Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing. BMC Genomics (2014) 0.77
DROSHA targets its own transcript to modulate alternative splicing. RNA (2017) 0.77
DGCR8 is essential for tumor progression following PTEN loss in the prostate. EMBO Rep (2015) 0.76
Drosha mediates destabilization of Lin28 mRNA targets. Cell Cycle (2012) 0.76
MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression. EMBO Rep (2017) 0.75
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Role of microRNAs in translation regulation and cancer. World J Biol Chem (2017) 0.75
Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins. Front Mol Biosci (2017) 0.75
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
MicroRNA signatures in human cancers. Nat Rev Cancer (2006) 46.29
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol (2005) 18.94
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007) 15.46
Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58
Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev (2006) 11.04
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27
Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol (2008) 7.35
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
Identification and classification of conserved RNA secondary structures in the human genome. PLoS Comput Biol (2006) 6.73
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol (2007) 5.91
A developmental view of microRNA function. Trends Biochem Sci (2007) 4.75
MicroRNA biogenesis and cancer. Cancer Res (2005) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76
Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
RNASEN regulates cell proliferation and affects survival in esophageal cancer patients. Clin Cancer Res (2006) 2.21
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res (2006) 1.97
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels. J Pathol (2007) 1.74
Crystal structure of human DGCR8 core. Nat Struct Mol Biol (2007) 1.74
MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol (2006) 1.69
Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA (2009) 1.59
Regulating the regulators: mechanisms controlling the maturation of microRNAs. Trends Biotechnol (2008) 1.16
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science (2012) 3.74
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J (2007) 2.37
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol (2007) 1.70
MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell (2010) 1.53
Suppression of HIV-1 replication by microRNA effectors. Retrovirology (2009) 1.44
A safe and effective method to implant a totally implantable access port in patients with synchronous bilateral mastectomies: modified femoral vein approach. J Surg Oncol (2008) 1.43
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun (2012) 1.35
Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat Struct Mol Biol (2011) 1.16
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA (2013) 1.15
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (2013) 1.09
Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet (2002) 0.98
Perforated acute appendicitis resulting from appendiceal villous adenoma presenting with small bowel obstruction: a case report. BMC Gastroenterol (2011) 0.98
Identification of novel neuronal isoforms of the Rho-GEF Trio. Biol Cell (2006) 0.95
Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell (2008) 0.91
Lin28a regulates germ cell pool size and fertility. Stem Cells (2013) 0.88
The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA (2013) 0.85
Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr (2012) 0.84
Comparison of transcatheter arterial chemoembolization, laparoscopic radiofrequency ablation, and conservative treatment for decompensated cirrhotic patients with hepatocellular carcinoma. World J Gastroenterol (2004) 0.84
Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol (2015) 0.84
Palladium-catalyzed three-component assembling of allenes, organic halides, and arylboronic acids. J Org Chem (2002) 0.83
MicroRNA regulation of stem cell fate. Cell Stem Cell (2008) 0.83
Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res (2011) 0.83
Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol (2010) 0.82
MicroRNAs and reprogramming. Nat Biotechnol (2011) 0.82
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest (2016) 0.80
Pumilio turns on microRNA function. Nat Cell Biol (2010) 0.75
Autoregulatory mechanisms controlling the microprocessor. Adv Exp Med Biol (2011) 0.75
Acute fulminant hepatitis B in a patient with diabetic nephropathy treated successfully with concomitant lamivudine and molecular adsorbents recirculating system. J Infect (2005) 0.75