PubRank

Frank B Gertler

Author PubWeight™ 139.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003 12.16
2 Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 2002 6.80
3 Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 2003 5.19
4 Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol 2003 4.22
5 Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 2004 3.65
6 Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004 3.48
7 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell 2004 3.27
8 An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet 2011 2.99
9 Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell 2004 2.96
10 Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem 2005 2.88
11 A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 2008 2.65
12 Filopodia are required for cortical neurite initiation. Nat Cell Biol 2007 2.49
13 Filopodia: the fingers that do the walking. Sci STKE 2007 2.43
14 Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res 2009 2.41
15 Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol 2007 2.30
16 Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A 2012 2.29
17 The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol 2011 2.22
18 Arp2/3 is a negative regulator of growth cone translocation. Neuron 2004 2.19
19 Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol Biol Cell 2007 2.12
20 Ena/VASP: towards resolving a pointed controversy at the barbed end. J Cell Sci 2009 2.05
21 Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron 2007 2.01
22 Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci 2011 2.00
23 In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet 2009 1.99
24 Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol Biol Cell 2005 1.93
25 The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal 2013 1.92
26 The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 2003 1.86
27 A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A 2003 1.84
28 Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell 2002 1.81
29 Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol 2009 1.78
30 Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development 2007 1.76
31 Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem 2003 1.72
32 Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2008 1.64
33 MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol 2006 1.61
34 Function and regulation of Ena/VASP proteins. Trends Cell Biol 2003 1.56
35 Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol 2007 1.53
36 Targeted disruption of the murine zyxin gene. Mol Cell Biol 2003 1.51
37 Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Mol Biol Cell 2002 1.47
38 Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res 2008 1.44
39 Ena/VASP: proteins at the tip of the nervous system. Curr Opin Neurobiol 2008 1.37
40 Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell 2010 1.35
41 Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton 2004 1.34
42 A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip 2010 1.33
43 The Ena/VASP enigma. J Cell Sci 2002 1.28
44 Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell 2008 1.27
45 Tuba stimulates intracellular N-WASP-dependent actin assembly. J Cell Sci 2006 1.26
46 Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell 2012 1.26
47 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol 2012 1.26
48 A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 2002 1.25
49 Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol 2010 1.24
50 Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res 2010 1.24
51 Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis 2011 1.23
52 Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. J Neurosci 2004 1.22
53 Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol 2002 1.20
54 Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Mol Microbiol 2003 1.20
55 VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci 2009 1.13
56 The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol 2010 1.11
57 Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells. Curr Biol 2013 1.11
58 The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Dev Cell 2010 1.10
59 WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J Cell Sci 2005 1.05
60 Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation. Development 2007 1.04
61 Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol 2012 0.98
62 Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast Cancer Res 2012 0.96
63 Mammalian enabled (Mena) is a critical regulator of cardiac function. Am J Physiol Heart Circ Physiol 2011 0.94
64 Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol 2009 0.93
65 Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Mol Cell Proteomics 2011 0.92
66 Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol 2011 0.92
67 Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice. Am J Physiol Heart Circ Physiol 2013 0.88
68 Ena/VASP proteins mediate repulsion from ephrin ligands. J Cell Sci 2006 0.85
69 Nervous Rac: DOCK7 regulation of axon formation. Neuron 2006 0.82
70 Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integr Biol (Camb) 2015 0.80
71 Cell autonomous defects in cortical development revealed by two-color chimera analysis. Mol Cell Neurosci 2009 0.80
72 Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Cell Microbiol 2004 0.80
73 Peptide array X-linking (PAX): a new peptide-protein identification approach. PLoS One 2012 0.78
74 Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer. J Histochem Cytochem 2012 0.76
75 Correction: eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol 2015 0.75