The function of activity-regulated genes in the nervous system.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 2828052)

Published in Physiol Rev on October 01, 2009

Authors

Sven Loebrich1, Elly Nedivi

Author Affiliations

1: The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Articles citing this

U1 snRNP determines mRNA length and regulates isoform expression. Cell (2012) 2.92

Epigenetic mechanisms in cognition. Neuron (2011) 2.31

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures. Dis Model Mech (2012) 1.27

Differential expression of microRNAs in mouse pain models. Mol Pain (2011) 1.15

Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffect Neurosci Psychol (2012) 1.14

Activity-regulated genes as mediators of neural circuit plasticity. Prog Neurobiol (2011) 1.13

The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Philos Trans R Soc Lond B Biol Sci (2013) 1.13

Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion. J Neurophysiol (2011) 1.07

FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. J Neurosci (2011) 1.05

Core and region-enriched networks of behaviorally regulated genes and the singing genome. Science (2014) 0.99

SynGAP isoforms exert opposing effects on synaptic strength. Nat Commun (2012) 0.97

CPG15 regulates synapse stability in the developing and adult brain. Genes Dev (2011) 0.97

Multiplexed Intact-Tissue Transcriptional Analysis at Cellular Resolution. Cell (2016) 0.93

Acute ketamine induces hippocampal synaptic depression and spatial memory impairment through dopamine D1/D5 receptors. Psychopharmacology (Berl) (2013) 0.93

Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition. Curr Alzheimer Res (2013) 0.93

Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal (2011) 0.92

Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci (2011) 0.91

New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Front Neurosci (2012) 0.91

Activity-dependent NPAS4 expression and the regulation of gene programs underlying plasticity in the central nervous system. Neural Plast (2013) 0.91

NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Res (2012) 0.91

Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs. BMC Genomics (2013) 0.89

Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. J Neurosci (2012) 0.89

A genetic polymorphism affecting reliance on personal versus public information in a spatial learning task in Drosophila melanogaster. Proc Biol Sci (2013) 0.88

Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. J Neurosci (2014) 0.87

Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements. J Neurosci (2013) 0.87

Chronic hyperoxia alters the expression of neurotrophic factors in the carotid body of neonatal rats. Respir Physiol Neurobiol (2010) 0.86

Localizing brain regions associated with female mate preference behavior in a swordtail. PLoS One (2012) 0.85

CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity. J Neurosci (2013) 0.84

Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat. J Neurophysiol (2011) 0.83

Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4. J Neurosci (2014) 0.81

Extreme thermal noxious stimuli induce pain responses in zebrafish larvae. J Cell Physiol (2014) 0.81

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review. Mol Genet Genomics (2014) 0.81

Npas4: Linking Neuronal Activity to Memory. Trends Neurosci (2016) 0.81

Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats. Neurobiol Aging (2012) 0.80

Transcriptional changes following long-term sensitization training and in vivo serotonin exposure in Aplysia californica. PLoS One (2012) 0.79

Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4. J Biol Chem (2012) 0.78

Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator. PLoS One (2011) 0.78

Absence of glucocorticoids augments stress-induced Mkp1 mRNA expression within the hypothalamic-pituitary-adrenal axis. J Endocrinol (2013) 0.78

Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms. Int J Mol Sci (2015) 0.78

Visualization and manipulation of neural activity in the developing vertebrate nervous system. Front Mol Neurosci (2011) 0.78

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation. Mol Cell Proteomics (2015) 0.78

An Evolutionarily Conserved Mechanism for Activity-Dependent Visual Circuit Development. Front Neural Circuits (2016) 0.77

Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins. Trends Neurosci (2014) 0.76

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex. Learn Mem (2014) 0.76

Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. PLoS One (2015) 0.76

Application of NeuroTrace staining in the fresh frozen brain samples to laser microdissection combined with quantitative RT-PCR analysis. BMC Res Notes (2015) 0.76

A PARP1-ERK2 synergism is required for the induction of LTP. Sci Rep (2016) 0.76

A synthetic luciferin improves in vivo bioluminescence imaging of gene expression in cardiovascular brain regions. Physiol Genomics (2016) 0.75

Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells. JCI Insight (2016) 0.75

The Neurotrophin Neuritin1 (cpg15) is involved in melanoma migration, attachment independent growth, and vascular mimicry. Oncotarget (2016) 0.75

Zebrafish models in neuropsychopharmacology and CNS drug discovery. Br J Pharmacol (2017) 0.75

A PARP1-Erk2 synergism is required for stimulation-induced expression of immediate early genes. Gene Transl Bioinform (2016) 0.75

Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo. Sci Rep (2017) 0.75

Yin-yang actions of histone methylation regulatory complexes in the brain. Epigenomics (2016) 0.75

Sweet taste receptor signaling network: possible implication for cognitive functioning. Neurol Res Int (2015) 0.75

Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice. Mol Neurobiol (2016) 0.75

Articles cited by this

(truncated to the top 100)

A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science (2008) 29.99

A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13

Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol (1973) 14.99

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (1984) 14.21

AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci (2002) 13.09

Memory--a century of consolidation. Science (2000) 12.95

Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (1993) 11.54

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell (1989) 11.41

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A (1986) 10.41

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences. Cell (1985) 10.00

Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature (1985) 9.73

Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature (1994) 9.37

Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06

Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell (1983) 9.03

The mGluR theory of fragile X mental retardation. Trends Neurosci (2004) 8.88

Fos and Jun: the AP-1 connection. Cell (1988) 8.78

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (1983) 8.60

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE. J Neurophysiol (1963) 8.01

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev (1989) 7.47

Cortical plasticity: from synapses to maps. Annu Rev Neurosci (1998) 7.24

Ferrier lecture. Functional architecture of macaque monkey visual cortex. Proc R Soc Lond B Biol Sci (1977) 7.24

Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci (2006) 7.18

Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron (2000) 7.15

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature (1986) 7.10

The self-tuning neuron: synaptic scaling of excitatory synapses. Cell (2008) 7.06

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression. Mol Cell Biol (1986) 7.06

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A (1991) 6.79

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell (1994) 6.67

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell (1988) 6.62

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature (1985) 6.41

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J (1985) 6.31

Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08

BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell (1999) 5.63

Functional requirement for class I MHC in CNS development and plasticity. Science (2000) 5.57

Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron (1995) 5.43

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science (1988) 5.29

Protein synthesis and memory: a review. Psychol Bull (1984) 5.26

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci U S A (1995) 5.25

Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol Cell Biol (1988) 5.21

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science (1995) 5.19

Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron (1996) 5.19

Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12

The metabotropic glutamate receptors: structure and functions. Neuropharmacology (1995) 5.11

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell (1984) 5.05

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron (2006) 4.98

Viral and cellular fos proteins: a comparative analysis. Cell (1984) 4.89

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 4.80

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci (1988) 4.77

CREB and memory. Annu Rev Neurosci (1998) 4.76

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (2006) 4.68

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (1984) 4.61

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (1987) 4.59

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron (1999) 4.59

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci (2000) 4.55

A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature (1996) 4.41

The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell (2003) 4.34

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science (1993) 4.31

Homer: a protein that selectively binds metabotropic glutamate receptors. Nature (1997) 4.18

Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res (2007) 4.13

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci (2000) 4.10

Activity-dependent regulation of inhibitory synapse development by Npas4. Nature (2008) 4.10

Mapping patterns of c-fos expression in the central nervous system after seizure. Science (1987) 4.07

Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97

Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science (1988) 3.95

Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron (1998) 3.95

Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature (1984) 3.86

Requirement of a critical period of transcription for induction of a late phase of LTP. Science (1994) 3.85

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet (2004) 3.83

polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes Dev (1991) 3.81

Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell (1983) 3.79

Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron (2000) 3.73

Transcription factors in long-term memory and synaptic plasticity. Physiol Rev (2009) 3.73

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron (1990) 3.70

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell (1994) 3.70

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1984) 3.70

The long and the short of long-term memory--a molecular framework. Nature (1986) 3.68

Purification of a new neurotrophic factor from mammalian brain. EMBO J (1982) 3.68

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron (1999) 3.68

Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron (2008) 3.65

Neurotrophins regulate dendritic growth in developing visual cortex. Neuron (1995) 3.64

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron (1998) 3.59

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci (2001) 3.56

Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc Natl Acad Sci U S A (1995) 3.52

Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron (2008) 3.48

Memory in mice as affected by intracerebral puromycin. Science (1963) 3.42

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature (1989) 3.39

Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron (2001) 3.30

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron (1993) 3.30

A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science (1986) 3.30

Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron (1999) 3.28

Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature (1993) 3.23

Regulation of heat shock protein 70 gene expression by c-myc. Nature (1984) 3.18

Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science (1985) 3.15

NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron (1990) 3.12

Articles by these authors

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc (2009) 5.68

Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol (2005) 2.61

Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex. Neuron (2012) 2.10

Structural basis for the role of inhibition in facilitating adult brain plasticity. Nat Neurosci (2011) 1.60

CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron (2004) 1.52

Multifocal multiphoton microscopy based on multianode photomultiplier tubes. Opt Express (2007) 1.28

A dynamic zone defines interneuron remodeling in the adult neocortex. Proc Natl Acad Sci U S A (2008) 1.21

Activity-regulated genes as mediators of neural circuit plasticity. Prog Neurobiol (2011) 1.13

Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis. Nat Neurosci (2005) 1.09

Neuronal structural remodeling: is it all about access? Curr Opin Neurobiol (2010) 1.03

Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes. J Neurosci (2002) 1.01

CPG15 regulates synapse stability in the developing and adult brain. Genes Dev (2011) 0.97

cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. J Comp Neurol (2008) 0.96

Regulation of cpg15 by signaling pathways that mediate synaptic plasticity. Mol Cell Neurosci (2003) 0.91

Highly specific structural plasticity of inhibitory circuits in the adult neocortex. Neuroscientist (2013) 0.84

Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice. J Neurobiol (2005) 0.84

Inhibitory dendrite dynamics as a general feature of the adult cortical microcircuit. J Neurosci (2011) 0.83

Spectral-resolved multifocal multiphoton microscopy with multianode photomultiplier tubes. Opt Express (2014) 0.80

Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A (2013) 0.80

Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15. J Neurosci (2014) 0.79

Non-descanned multifocal multiphoton microscopy with a multianode photomultiplier tube. AIP Adv (2015) 0.78