Published in Cell on October 02, 2009
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A (2010) 2.38
Control of ribosomal subunit rotation by elongation factor G. Science (2013) 1.90
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother (2012) 1.61
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
Enabling technologies in discovery: the 2009 Nobel Prize and its implications in antibiotic design. Anal Bioanal Chem (2010) 0.75
Development and characterization of a Pseudomonas aeruginosa in vitro coupled transcription-translation assay system for evaluation of translation inhibitors. J Microbiol Methods (2012) 0.75
How Ribosomes Translate Cancer. Cancer Discov (2017) 0.75
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Cell (2005) 2.97
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature (2010) 2.85
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol Cell (2007) 2.62
Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Mol Cell (2008) 2.37
Structures of the human and Drosophila 80S ribosome. Nature (2013) 2.36
Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science (2012) 2.28
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. Cell (2006) 2.19
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A (2010) 1.99
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell (2005) 1.93
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. Mol Cell (2004) 1.83
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chem Biol (2008) 1.79
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. Proc Natl Acad Sci U S A (2008) 1.78
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. PLoS Biol (2011) 1.68
Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. BMC Biol (2004) 1.68
Maintaining the ribosomal reading frame: the influence of the E site during translational regulation of release factor 2. Cell (2004) 1.68
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome. Proc Natl Acad Sci U S A (2010) 1.68
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nat Struct Mol Biol (2010) 1.68
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother (2012) 1.61
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
Nascent peptides that block protein synthesis in bacteria. Proc Natl Acad Sci U S A (2013) 1.52
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nat Struct Mol Biol (2008) 1.50
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol (2006) 1.47
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition. Biochemistry (2006) 1.46
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. Nat Chem Biol (2012) 1.45
X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit. EMBO J (2004) 1.43
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. Mol Cell (2010) 1.35
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P. Proc Natl Acad Sci U S A (2013) 1.30
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis. Proc Natl Acad Sci U S A (2013) 1.30
Species-specific antibiotic-ribosome interactions: implications for drug development. Biol Chem (2005) 1.27
The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (2005) 1.26
A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure (2007) 1.25
New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation. J Mol Biol (2008) 1.23
Structural aspects of RbfA action during small ribosomal subunit assembly. Mol Cell (2007) 1.20
Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition. Chem Biol (2010) 1.16
The bacterial translation stress response. FEMS Microbiol Rev (2014) 1.14
Mechanisms of SecM-mediated stalling in the ribosome. Biophys J (2012) 1.11
Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. Proc Natl Acad Sci U S A (2008) 1.08
Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins. Proc Natl Acad Sci U S A (2007) 1.07
Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A (2012) 1.01
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. J Biol Chem (2002) 1.01
Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu. Nucleic Acids Res (2005) 1.00
PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G). J Biol Chem (2009) 0.99
Antibiotics acting on the translational machinery. J Cell Sci (2003) 0.98
Tetracycline antibiotics and resistance mechanisms. Biol Chem (2014) 0.97
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini. Angew Chem Int Ed Engl (2009) 0.96
Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins. Mol Microbiol (2011) 0.93
Molecular mimicry in the decoding of translational stop signals. Prog Nucleic Acid Res Mol Biol (2003) 0.92
Probing translation with small-molecule inhibitors. Chem Biol (2010) 0.91
Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections. Expert Opin Pharmacother (2008) 0.91
Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother (2011) 0.90
Localization of the trigger factor binding site on the ribosomal 50S subunit. J Mol Biol (2003) 0.90
Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins. J Mol Biol (2010) 0.90
Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution. Nucleic Acids Res (2012) 0.89
SnapShot: Antibiotic inhibition of protein synthesis I. Cell (2009) 0.88
Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. Antimicrob Agents Chemother (2009) 0.87
Time-resolved binding of azithromycin to Escherichia coli ribosomes. J Mol Biol (2008) 0.87
Polyamines affect diversely the antibiotic potency: insight gained from kinetic studies of the blasticidin S AND spiramycin interactions with functional ribosomes. J Biol Chem (2004) 0.87
On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics. Mol Pharmacol (2006) 0.86
The how and Y of cold shock. Nat Struct Mol Biol (2004) 0.82
RelBE or not to be. Nat Struct Mol Biol (2005) 0.81
On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel. Biochimie (2013) 0.81
The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux. Antimicrob Agents Chemother (2009) 0.81
Amythiamicin D and related thiopeptides as inhibitors of the bacterial elongation factor EF-Tu: modification of the amino acid at carbon atom C2 of ring C dramatically influences activity. ChemMedChem (2013) 0.81
Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388. Chem Biol (2009) 0.79
The DARC site: a database of aligned ribosomal complexes. Nucleic Acids Res (2011) 0.79
Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis. Antimicrob Agents Chemother (2013) 0.79
Corrigendum: Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nat Chem Biol (2015) 0.77
[Ribosome recycling revisited]. Mol Biol (Mosk) (2006) 0.75