Published in Cell on July 09, 2004
Fidelity at the molecular level: lessons from protein synthesis. Cell (2009) 2.65
Quality control by the ribosome following peptide bond formation. Nature (2008) 2.15
RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs. Genes Dev (2009) 1.87
Cellular mechanisms that control mistranslation. Nat Rev Microbiol (2010) 1.60
Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol (2006) 1.51
A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment. Microbiol Mol Biol Rev (2009) 1.50
X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit. EMBO J (2004) 1.43
Messenger RNA conformations in the ribosomal E site revealed by X-ray crystallography. EMBO Rep (2007) 1.33
Genetic analysis of the E site during RF2 programmed frameshifting. RNA (2007) 1.23
Preferred and avoided codon pairs in three domains of life. BMC Genomics (2008) 1.19
A role for the 30S subunit E site in maintenance of the translational reading frame. RNA (2008) 1.13
Function of the ribosomal E-site: a mutagenesis study. Nucleic Acids Res (2005) 1.12
The complex of tmRNA-SmpB and EF-G on translocating ribosomes. Nature (2012) 1.09
Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. Proc Natl Acad Sci U S A (2008) 1.08
rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics (2013) 1.04
Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu. Nucleic Acids Res (2005) 1.00
A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshifting. Nucleic Acids Res (2008) 0.97
Further in vitro exploration fails to support the allosteric three-site model. J Biol Chem (2012) 0.97
Features of 80S mammalian ribosome and its subunits. Nucleic Acids Res (2008) 0.96
Crystal structure of 70S ribosome with both cognate tRNAs in the E and P sites representing an authentic elongation complex. PLoS One (2013) 0.95
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol Cell (2015) 0.94
Proximity of the start codon to a leaderless mRNA's 5' terminus is a strong positive determinant of ribosome binding and expression in Escherichia coli. J Bacteriol (2010) 0.93
Autoregulatory systems controlling translation factor expression: thermostat-like control of translational accuracy. RNA (2010) 0.90
EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. Nat Struct Mol Biol (2016) 0.88
Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. Nat Struct Mol Biol (2016) 0.88
Short spacing between the Shine-Dalgarno sequence and P codon destabilizes codon-anticodon pairing in the P site to promote +1 programmed frameshifting. Mol Microbiol (2010) 0.88
The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance. PLoS One (2013) 0.88
Regulation of programmed ribosomal frameshifting by co-translational refolding RNA hairpins. PLoS One (2013) 0.86
Maintenance of protein synthesis reading frame by EF-P and m(1)G37-tRNA. Nat Commun (2015) 0.86
Titration and conditional knockdown of the prfB gene in Escherichia coli: effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase. Appl Environ Microbiol (2006) 0.86
Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. Mol Cell (2015) 0.83
FSscan: a mechanism-based program to identify +1 ribosomal frameshift hotspots. Nucleic Acids Res (2009) 0.82
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use. Nucleic Acids Res (2016) 0.82
Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing-activated transfer of a mobile genetic element. Proc Natl Acad Sci U S A (2015) 0.81
The tri-frame model. J Theor Biol (2007) 0.81
Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes. Structure (2010) 0.80
The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS One (2015) 0.78
The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts. Int J Mol Sci (2015) 0.78
Coupling of mRNA Structure Rearrangement to Ribosome Movement during Bypassing of Non-coding Regions. Cell (2015) 0.78
Anticodon loop mutations perturb reading frame maintenance by the E site tRNA. RNA (2008) 0.77
The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis. RNA Biol (2015) 0.76
The 55S mammalian mitochondrial ribosome and its tRNA-exit region. Biochimie (2015) 0.75
Codon-Anticodon Recognition in the Bacillus subtilis glyQS T Box Riboswitch: RNA-DEPENDENT CODON SELECTION OUTSIDE THE RIBOSOME. J Biol Chem (2015) 0.75
Study on the chaperone properties of conserved GTPases. Protein Cell (2012) 0.75
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J (2002) 3.57
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Small RNA binding to 5' mRNA coding region inhibits translational initiation. Mol Cell (2008) 2.88
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature (2010) 2.85
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol Cell (2007) 2.62
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol (2003) 2.57
Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Mol Cell (2008) 2.37
Structures of the human and Drosophila 80S ribosome. Nature (2013) 2.36
Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science (2012) 2.28
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. Cell (2006) 2.19
An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis? Mol Cell (2009) 2.03
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A (2010) 1.99
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
The weird and wonderful world of bacterial ribosome regulation. Crit Rev Biochem Mol Biol (2007) 1.97
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell (2005) 1.93
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. Mol Cell (2004) 1.83
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Mol Cell (2009) 1.82
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chem Biol (2008) 1.79
Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob Agents Chemother (2003) 1.70
Ribosomal proteins in the spotlight. Crit Rev Biochem Mol Biol (2005) 1.69
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. PLoS Biol (2011) 1.68
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome. Proc Natl Acad Sci U S A (2010) 1.68
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nat Struct Mol Biol (2010) 1.68
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother (2012) 1.61
Fast biosynthesis of GFP molecules: a single-molecule fluorescence study. Angew Chem Int Ed Engl (2009) 1.53
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
Nascent peptides that block protein synthesis in bacteria. Proc Natl Acad Sci U S A (2013) 1.52
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nat Struct Mol Biol (2008) 1.50
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol (2006) 1.47
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition. Biochemistry (2006) 1.46
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. Nat Chem Biol (2012) 1.45
Transterm--extended search facilities and improved integration with other databases. Nucleic Acids Res (2006) 1.44
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. Mol Cell (2010) 1.35
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A (2004) 1.31
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P. Proc Natl Acad Sci U S A (2013) 1.30
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis. Proc Natl Acad Sci U S A (2013) 1.30
Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell (2011) 1.28
Species-specific antibiotic-ribosome interactions: implications for drug development. Biol Chem (2005) 1.27
Transterm: a database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Res (2008) 1.27
The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (2005) 1.26
A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure (2007) 1.25
Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations. Proc Natl Acad Sci U S A (2011) 1.24
New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation. J Mol Biol (2008) 1.23
Three-dimensional structures of translating ribosomes by Cryo-EM. Mol Cell (2004) 1.21
Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria. Proc Natl Acad Sci U S A (2005) 1.21
Structural aspects of RbfA action during small ribosomal subunit assembly. Mol Cell (2007) 1.20
Mechanism of Tet(O)-mediated tetracycline resistance. EMBO J (2003) 1.19
Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition. Chem Biol (2010) 1.16
The bacterial translation stress response. FEMS Microbiol Rev (2014) 1.14
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis (2008) 1.12
Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Res (2006) 1.12
Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome. Curr Protein Pept Sci (2002) 1.11
Mechanisms of SecM-mediated stalling in the ribosome. Biophys J (2012) 1.11
The ribosome through the looking glass. Angew Chem Int Ed Engl (2003) 1.10
The complex of tmRNA-SmpB and EF-G on translocating ribosomes. Nature (2012) 1.09
Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. Proc Natl Acad Sci U S A (2008) 1.08
Retracted A dedicated translation factor controls the synthesis of the global regulator Fis. EMBO J (2004) 1.07
Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins. Proc Natl Acad Sci U S A (2007) 1.07
RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet (2012) 1.06
Stepping transfer messenger RNA through the ribosome. J Biol Chem (2005) 1.01
Dissociation of intact Escherichia coli ribosomes in a mass spectrometer. Evidence for conformational change in a ribosome elongation factor G complex. J Biol Chem (2002) 1.01
Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A (2012) 1.01
Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. J Biol Chem (2007) 1.01
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. J Biol Chem (2002) 1.01
Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu. Nucleic Acids Res (2005) 1.00
Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. J Neurosci (2007) 1.00
NOA1 is an essential GTPase required for mitochondrial protein synthesis. Mol Biol Cell (2010) 1.00
PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G). J Biol Chem (2009) 0.99
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Res (2011) 0.99
DnaK-facilitated ribosome assembly in Escherichia coli revisited. RNA (2003) 0.98
Tetracycline antibiotics and resistance mechanisms. Biol Chem (2014) 0.97
Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini. Angew Chem Int Ed Engl (2009) 0.96
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
Cell-free protein expression and functional assay in nanowell chip format. Anal Chem (2004) 0.96
Features of 80S mammalian ribosome and its subunits. Nucleic Acids Res (2008) 0.96
Enhanced SnapShot: Antibiotic inhibition of protein synthesis II. Cell (2009) 0.96
RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon. J Biol Chem (2003) 0.95
Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells. J Clin Invest (2011) 0.95
Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins. Mol Microbiol (2011) 0.93
The tetracycline resistance protein Tet(o) perturbs the conformation of the ribosomal decoding centre. Mol Microbiol (2002) 0.92
Molecular mimicry in the decoding of translational stop signals. Prog Nucleic Acid Res Mol Biol (2003) 0.92
Tandem termination signals: myth or reality? FEBS Lett (2002) 0.91
Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus (2011) 0.91
Probing translation with small-molecule inhibitors. Chem Biol (2010) 0.91
Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS One (2012) 0.90
Mapping of the second tetracycline binding site on the ribosomal small subunit of E.coli. Nucleic Acids Res (2004) 0.90