Published in Angew Chem Int Ed Engl on January 01, 2009
Reliable semi-synthesis of hydrolysis-resistant 3'-peptidyl-tRNA conjugates containing genuine tRNA modifications. Nucleic Acids Res (2010) 0.84
Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligation. Chembiochem (2012) 0.83
Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs. Bioorg Med Chem (2011) 0.82
Small molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA. Int J Mol Sci (2013) 0.81
The synthesis of methylated, phosphorylated, and phosphonated 3'-aminoacyl-tRNA(Sec) mimics. Chemistry (2013) 0.80
Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size. Cell Rep (2016) 0.78
Synthesis of aminoacylated N(6),N(6)-dimethyladenosine solid support for efficient access to hydrolysis-resistant 3'-charged tRNA mimics. Bioorg Med Chem (2014) 0.76
Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker. Curr Protoc Nucleic Acid Chem (2010) 0.76
Molecular insights into protein synthesis with proline residues. EMBO Rep (2016) 0.75
Preparation of modified long-mer RNAs and analysis of FMN binding to the ypaA aptamer from B. subtilis. RNA Biol (2014) 0.75
Conformational and chemical selection by a trans-acting editing domain. Proc Natl Acad Sci U S A (2017) 0.75
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44
Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus. Mol Microbiol (2005) 4.52
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature (2010) 2.85
Non-coding RNAs: hope or hype? Trends Genet (2005) 2.74
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol Cell (2007) 2.62
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Mol Cell (2008) 2.37
Structures of the human and Drosophila 80S ribosome. Nature (2013) 2.36
Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science (2012) 2.28
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. Cell (2006) 2.19
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol (2010) 2.13
Ligand-induced folding of the adenosine deaminase A-riboswitch and implications on riboswitch translational control. Chembiochem (2007) 2.12
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A (2010) 1.99
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. Mol Cell (2011) 1.96
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell (2005) 1.93
Conformational capture of the SAM-II riboswitch. Nat Chem Biol (2011) 1.84
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. Mol Cell (2004) 1.83
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach. Nucleic Acids Res (2007) 1.79
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chem Biol (2008) 1.79
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. PLoS Biol (2011) 1.68
Maintaining the ribosomal reading frame: the influence of the E site during translational regulation of release factor 2. Cell (2004) 1.68
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome. Proc Natl Acad Sci U S A (2010) 1.68
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nat Struct Mol Biol (2010) 1.68
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother (2012) 1.61
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
Nascent peptides that block protein synthesis in bacteria. Proc Natl Acad Sci U S A (2013) 1.52
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nat Struct Mol Biol (2008) 1.50
Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells. Nucleic Acids Res (2007) 1.49
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol (2006) 1.47
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition. Biochemistry (2006) 1.46
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. Nat Chem Biol (2012) 1.45
tRNA-derived fragments target the ribosome and function as regulatory non-coding RNA in Haloferax volcanii. Archaea (2012) 1.43
The dynamic nature of RNA as key to understanding riboswitch mechanisms. Acc Chem Res (2011) 1.39
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. Mol Cell (2010) 1.35
Folding of a transcriptionally acting preQ1 riboswitch. Proc Natl Acad Sci U S A (2010) 1.34
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P. Proc Natl Acad Sci U S A (2013) 1.30
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis. Proc Natl Acad Sci U S A (2013) 1.30
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451. Nucleic Acids Res (2005) 1.29
Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome. PLoS Pathog (2009) 1.28
The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (2005) 1.26
A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure (2007) 1.25
New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation. J Mol Biol (2008) 1.23
Pseudoknot preorganization of the preQ1 class I riboswitch. J Am Chem Soc (2012) 1.20
Structural aspects of RbfA action during small ribosomal subunit assembly. Mol Cell (2007) 1.20
Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2'-OH at A2451 of 23S rRNA. J Am Chem Soc (2006) 1.20
Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-methylseleno labels for use in X-ray crystallography. J Am Chem Soc (2005) 1.18
Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition. Chem Biol (2010) 1.16
An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination. Nucleic Acids Res (2007) 1.15
Chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an U6 SnRNA stem-loop segment. J Am Chem Soc (2004) 1.15
The preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized RNA fragments. Nat Protoc (2008) 1.15
The bacterial translation stress response. FEMS Microbiol Rev (2014) 1.14
Epstein-barr virus-induced expression of a novel human vault RNA. J Mol Biol (2009) 1.12
Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms. Dev Biol (2009) 1.11
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res (2007) 1.11
Mechanisms of SecM-mediated stalling in the ribosome. Biophys J (2012) 1.11
Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy. J Mol Biol (2003) 1.11
Tuning a riboswitch response through structural extension of a pseudoknot. Proc Natl Acad Sci U S A (2013) 1.09
Revealing stable processing products from ribosome-associated small RNAs by deep-sequencing data analysis. Nucleic Acids Res (2012) 1.08
Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. Proc Natl Acad Sci U S A (2008) 1.08
Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution. Proc Natl Acad Sci U S A (2013) 1.08
Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins. Proc Natl Acad Sci U S A (2007) 1.07
Ribose 2'-F labeling: a simple tool for the characterization of RNA secondary structure equilibria by 19F NMR spectroscopy. J Am Chem Soc (2005) 1.06
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers. Chembiochem (2009) 1.05
Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation. Nat Chem Biol (2010) 1.01
Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A (2012) 1.01
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. J Biol Chem (2002) 1.01
Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu. Nucleic Acids Res (2005) 1.00
Long non-coding RNAs as targets for cytosine methylation. RNA Biol (2013) 1.00
PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G). J Biol Chem (2009) 0.99
Synthesis of (6-(13)C)pyrimidine nucleotides as spin-labels for RNA dynamics. J Am Chem Soc (2012) 0.99
5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy. Nucleic Acids Res (2009) 0.99
Tetracycline antibiotics and resistance mechanisms. Biol Chem (2014) 0.97
A general approach for the identification of site-specific RNA binders by 19F NMR spectroscopy: proof of concept. Angew Chem Int Ed Engl (2006) 0.96
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
Enhanced SnapShot: Antibiotic inhibition of protein synthesis II. Cell (2009) 0.96
A powerful approach for the selection of 2-aminopurine substitution sites to investigate RNA folding. J Am Chem Soc (2011) 0.96
Synthesis, oxidation behavior, crystallization and structure of 2'-methylseleno guanosine containing RNAs. J Am Chem Soc (2006) 0.95
Ribosome-associated GTPases: the role of RNA for GTPase activation. RNA Biol (2010) 0.94
19F NMR spectroscopy for the analysis of RNA secondary structure populations. J Am Chem Soc (2008) 0.94
Chemical synthesis of site-specifically 2'-azido-modified RNA and potential applications for bioconjugation and RNA interference. Chembiochem (2011) 0.94
Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins. Mol Microbiol (2011) 0.93